Which lens implant delivers sharper sight after cataract surgery?
NCT ID NCT07768475
First seen Aug 17, 2026 · Last updated Aug 18, 2026 · Updated 1 time
Summary
This trial compares two types of intraocular lenses implanted during cataract surgery: the Clareon PanOptix and the Tecnis Odyssey. About 266 adults with cataracts in both eyes will receive one lens type in each eye, and researchers will measure how well they see at various distances and how satisfied they are. The goal is to see if one lens offers better visual outcomes or patient satisfaction than the other.
What this could mean
Our plain-language read of the trial. This is informational only, not medical advice or a prediction.
- Active substance
- Intraocular lens implants: Clareon PanOptix and Tecnis Odyssey
- What this could lead to
- If one lens proves better, it could guide surgeons in choosing implants that give sharper vision and higher satisfaction after cataract surgery.
- What could go wrong
- This is a single-center study, and results may not apply to all patients. Individual outcomes vary, and neither lens may show a clear advantage.
This is an AI summary of the original study and may miss details. Read our disclaimer.
Study facts
What this study's own registry entry says, in plain language.
- Phase
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Not a phased trial
Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.
- Participants
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266 people
The number who actually took part.
- Started
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Jul 2025
- Expected to finish
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Nov 2026
An estimate. End dates often move.
- Lead sponsor
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A company
The lead sponsor is a pharmaceutical, biotech, or medical-device company.
Who can take part
This study's own entry requirements. Only the study team can say for certain whether you qualify.
- Ages
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Children (under 18), adults (18 to 64) and older adults (65 and over)
- Sex
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Anyone
- Healthy volunteers
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Not accepted
This study is not open to healthy volunteers. The entry requirements below say who it is open to.
Show the full entry requirements Hide the full entry requirements
Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.
Inclusion Criteria: 1. Willing and able to understand and sign informed consent 2. Willing and able to participate with all study testing 3. Adult patient diagnosed with age-related cataracts bilaterally 4. Planned bilateral cataract removal by phacoemulsification with bilateral implantation of the Clareon PanOptix/ Clareon PanOptix Toric or Tecnis Odyssey IOL/ Tecnis Odyssey IOL Toric (T3/4 or DRT150, DRT225) 5. Best monocular corrected distance visual acuity expected to be 0.1 logMAR (Snellen 20/25) or better in both eyes postoperatively as determined by surgeon 6. Residual astigmatism expected to be ≤ 0.50 diopters in both eyes postoperatively as determined by surgeon (After using either toric IOL or arcuate incision with laser) 7. Normal ocular findings aside from cataract Exclusion Criteria: 1. HOA greater than 0.4 μm within central 4 mm 2. Corneal dystrophies, degenerations, irregular astigmatism or any corneal abnormality aside from regular astigmatism deemed to be of clinical significance by the surgeon. 3. Any pathologic conditions that might affect ease of cataract removal (pseudoexfoliation, posterior polar, etc) as determined by surgeon 4. Strabismus with or without amblyopia in either eye 5. Previous history of any ocular surgery including corneal refractive surgery 6. Presence of any macular disease, history of retinal detachment, or posterior segment abnormality deemed to be of clinical significance by the surgeon. 7. Presence of glaucoma 8. Presence of any acute or chronic systemic disease that would confound the results of this study as determined by the surgeon (e.g. uncontrolled diabetes, immunocompromise, autoimmune disease, etc). 9. Any planned simultaneous/combined procedures at time of cataract surgery (e.g. MIGs). 10. Any subjects with intraoperative complications, including vitreous loss, posterior capsular rupture, zonular dialysis, decentered or tilted IOL, diffuse corneal epithelial defect, and use of iris hooks or expanders, will be excluded from analysis.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
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Hyperspeed LASIK
Rowland Heights, California, 91748, United States
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Parkhurst Nuvision
San Antonio, Texas, 78229, United States
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Seeta Eye Center
Poughkeepsie, New York, 12603, United States
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Texas Eye and Laser Center
Hurst, Texas, 76054, United States
More trials for these conditions
Other studies related to the condition(s) this trial covers.
- Seeing inside the eye during surgery: a new imaging tool could sharpen lens disease care
- Can Mix-and-Match lenses improve vision after cataract surgery?
- Can AI and a new eye scanner make cataract surgery results more predictable?
- Blue dye under the microscope: could a routine cataract tool damage corneal cells?
- A new lens design aims to improve vision after cataract surgery
- Which lens gives sharper sight after cataract surgery? a Head-to-Head trial