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New study aims to improve brain bypass surgery outcomes

NCT ID NCT07396025

Knowledge-focused Sponsor: National Centre for Neurosurgery, Republic of Kazakhstan Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only This study
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 26, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study looks at how well surgical and diagnostic techniques work for people with blocked carotid arteries, a major cause of stroke. Researchers will follow 60 patients to see how bypass surgery affects blood flow, thinking skills, and recovery. The goal is to find better ways to choose who needs surgery and to improve results.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

What this could lead to
If successful, this could lead to better surgical techniques and clearer guidelines for treating carotid artery occlusion, potentially improving patient recovery and reducing risks.
What could go wrong
This is an early-stage observational study with only 60 participants, so results may not apply to everyone. The study focuses on refining methods rather than proving a new treatment works.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

About 60 people

The number the study aims to enrol. It can still change while the study runs.

Started

Jul 2025

Expected to finish

Dec 2027

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 years and older

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: 1. Patients with ICA occlusion confirmed by CTA, MRA, and cerebral DSA. 2. MRI ASL-confirmed hypoperfusion in the territory of the occluded ICA (decrease of ≥30% compared with the contralateral side) 3. Language comprehension is preserved, with mild or no motor aphasia and no significant cognitive impairment. 4. Patients aged from 18 to 80 years. 5. Modified Rankin Scale (mRS) score 0-2. 6. Informed consent is available from the patient or legal guardian. 7. Accessible and reliable patients for follow-up Exclusion Criteria: 1. Patients with large territorial infarction or marked cerebral atrophy on MRI. 2. No evidence of regional hypoperfusion on ASL MRI relative to the contralateral hemisphere. 3. Patients with a non-functioning STA-MCA bypass 4. Patients aged under 18 5. Patients with severe somatic conditions or mRS score \> 3 6. Patients with bilateral ICA occlusion, neurovascular disease (cerebral aneurysm or arteriovenous malformation) 7. Patients with Contraindications to MRI, CTA, or DSA 8. Cardiac conditions associated with a high risk of cerebral embolism, including prosthetic heart valves, infective endocarditis, intracardiac thrombus, sick sinus syndrome, cardiac myxoma, or cardiomyopathy with left ventricular ejection fraction \<25% (atrial fibrillation, patent foramen ovale, and atrial septal aneurysm are not exclusion criteria). 9. Severe systemic comorbidities, life expectancy \<2 years, or a modified Rankin Scale (mRS) score \>3. 10. Pregnancy. 11. Contraindications to MRI, CTA, DSA, iodinated contrast agents, or antiplatelet therapy required in the perioperative period. 12. Participation in another interventional or experimental trial within the previous 12 months, including studies involving ionizing radiation \-

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Conditions

The condition(s) this trial relates to.

atherosclerosis carotid artery occlusion stroke disorder

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Carotid artery occlusion

How to take part

Only the study team decides who joins. These are the ways to reach them.

  1. The places running it

    1 site. The list below names each one and where it is.

  2. The official record

    The full official record for this study. This one lists no contact details, but it is the first place any would appear.

    Open the record ↗

  3. A doctor treating you

    A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.

Contacts and locations

Locations

  • National Centre for Neurosurgery

    Astana, 01000, Kazakhstan

More trials for these conditions

Other studies related to the condition(s) this trial covers.