Hidden heart condition may be common in seniors with heart failure
NCT ID NCT06427304
First seen Jun 27, 2026 · Last updated Jun 27, 2026
Summary
This study looks at how often cardiac amyloidosis—a condition where abnormal proteins build up in the heart—occurs in people aged 80 and older who have been hospitalized for heart failure. Researchers will use bone scans to detect the condition in 637 participants. The goal is to find out how many of these older patients have undiagnosed cardiac amyloidosis, which could help improve future screening and care.
What this could mean
Our plain-language read of the trial. This is informational only, not medical advice or a prediction.
- What this could lead to
- If successful, this could show that cardiac amyloidosis is a common, hidden cause of heart failure in older adults, leading to better screening and earlier diagnosis.
- What could go wrong
- This is an observational study, not a treatment trial. It will not test any therapy, and the results may not apply to all older adults with heart failure.
This is an AI summary of the original study and may miss details. Read our disclaimer.
Study facts
What this study's own registry entry says, in plain language.
- Participants
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About 637 people
The number the study aims to enrol. It can still change while the study runs.
- Started
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Jul 2024
- Expected to finish
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Feb 2028
An estimate. End dates often move.
- Lead sponsor
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Other sponsor
The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.
Who can take part
This study's own entry requirements. Only the study team can say for certain whether you qualify.
Who is studied
Patients with cardiac amyloidosis expressed by a positive bone scintigraphy.
- Ages
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80 years and older
- Sex
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Anyone
- Healthy volunteers
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Not accepted
This study is not open to healthy volunteers. The entry requirements below say who it is open to.
Show the full entry requirements Hide the full entry requirements
Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.
Inclusion Criteria: * Aged ≥ 80 years * Hospitalised for decompensation of heart failure in the last 12 months * Subjects with hypertrophy of the septum or left ventricle at cardiac echography (defined as ≥ 12 mm) * Subjects able to undergo a bone scintigraphy scan * Subjects willing to participate Exclusion Criteria: * Subjects refusing to participate * Subjects admitted to palliative care unit. * Subjects under guardianship * Subjects with a definite diagnosis of cardiac amyloidosis
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Get notified about this study
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
How to take part
Only the study team decides who joins. These are the ways to reach them.
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The places running it
36 sites. The list below names each one and where it is.
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The official record
ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.
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A doctor treating you
A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.
Contacts and locations
Locations
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Ambroise Paré Hospital
RECRUITINGBoulogne-Billancourt, Île-de-France Region, 92100, France
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Bretonneau Hospital
RECRUITINGParis, Île-de-France Region, 75018, France
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CHRU Nancy
RECRUITINGNancy, 54000, France
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CHRU Tours-Bretonneau Hospital
RECRUITINGTours, 37000, France
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CHU Amiens Picardie
RECRUITINGAmiens, 80000, France
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CHU Angers
RECRUITINGAngers, 49100, France
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CHU Bordeaux
RECRUITINGBordeaux, 33000, France
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CHU Dijon
RECRUITINGDijon, 21000, France
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CHU Grenoble Alpes
RECRUITINGGrenoble, 38700, France
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CHU Lille
RECRUITINGLille, 59000, France
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CHU Limoges
RECRUITINGLimoges, 87000, France
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CHU Lyon
RECRUITINGLyon, 69002, France
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CHU Marseille
RECRUITINGMarseille, 13005, France
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CHU Montpellier
RECRUITINGMontpellier, Occitanie, 34090, France
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CHU Nantes
RECRUITINGNantes, Loire-Atlantique, 44000, France
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CHU Nice
RECRUITINGNice, 06000, France
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CHU Orléans
RECRUITINGOrléans, 45100, France
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CHU Poitiers
RECRUITINGPoitiers, New Aquitaine, 86000, France
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CHU Rennes
RECRUITINGRennes, 35000, France
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CHU Rouen, Charles Nicole hospital
RECRUITINGRouen, Normandy, 76000, France
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CHU Toulouse
RECRUITINGToulouse, Occitanie, 31300, France
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CHU Trousseau-Tours
RECRUITINGChambray-lès-Tours, 37170, France
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Centre Hospitalier Intercommunal de Castres-Mazamet
RECRUITINGCastres, 81100, France
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Centre Hospitalier de Carcassonne
RECRUITINGCarcassonne, 11100, France
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Charles Foix Hospital
RECRUITINGIvry-sur-Seine, Île-de-France Region, 94200, France
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Clinique Saint Joseph Trelaze
RECRUITINGTrélazé, 49800, France
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Clinique du Millénaire-Montpellier
RECRUITINGMontpellier, 34000, France
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Corentin Celton Hospital
NOT_YET_RECRUITINGIssy-les-Moulineaux, Île-de-France Region, 92130, France
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Emile Roux Hospital
RECRUITINGLimeil-Brévannes, Île-de-France Region, 94450, France
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Europeen Georges Pompidou Hospital
RECRUITINGParis, Île-de-France Region, 75015, France
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GH Sud Ile-de-France
RECRUITINGMelun, Île-de-France Region, 77000, France
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Geriatric Department, Broca Hospital
RECRUITINGParis, IIe-de-France, 75013, France
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Hôpital Privé Gériatrique LES SOURCES-Nice
RECRUITINGNice, 06100, France
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Lariboisière Hospital
RECRUITINGParis, Île-de-France Region, 75010, France
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Médipôle Hôpital Mutualiste Villeurbanne
RECRUITINGVilleurbanne, 69100, France
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Saint Joseph Hospital
RECRUITINGParis, Île-de-France Region, 75014, France
More trials for these conditions
Other studies related to the condition(s) this trial covers.
- Which SGLT2 inhibitor wins? trial pits empagliflozin against dapagliflozin
- Can daily mindful breathing ease heart failure symptoms?
- Can a smartphone app keep heart failure patients out of the hospital?
- Can better training get doctors to talk about what matters most to dying veterans?
- Can AI read heart ultrasounds as well as trained sonographers?
- Can modern heart failure drugs reverse damage in three months?