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New CAR t therapy targets hidden lymphoma cells after initial treatment

NCT ID NCT06500273

Disease control Sponsor: Allogene Therapeutics Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now This study
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 27, 2026 · Last updated Sep 01, 2026 · Updated 6 times

Summary

This study tests a new cell therapy called cemacabtagene ansegedleucel (cema-cel) in adults with large B-cell lymphoma who still have tiny amounts of cancer cells (minimal residual disease) after finishing their first standard treatment. About 250 participants will be randomly assigned to receive either cema-cel or standard monitoring. The goal is to see if this therapy can prevent the cancer from coming back.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Phase 2

Tests whether the treatment actually works, and watches for side effects, in a larger group.

Participants

About 250 people

The number the study aims to enrol. It can still change while the study runs.

Started

Jun 2024

Expected to finish

Dec 2032

An estimate. End dates often move.

Lead sponsor

A company

The lead sponsor is a pharmaceutical, biotech, or medical-device company.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 years and older

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Key Inclusion Criteria: 1. LBCL per WHO 2017 including diffuse large B-cell lymphoma, high-grade B-cell lymphoma, and primary mediastinal B-cell lymphoma histologically confirmed by pathology report. 2. Participant has completed a full course of standard first line therapy (e.g., R-CHOP, dose-adjusted EPOCH-R, Pola-R-CHP) as intended. Participants cannot have received additional lines of therapy. 3. Participant achieved CR, or PR suitable for observation, at the end of first line therapy based on PET/CT evaluation 4. Foresight CLARITY™ IUO MRD test, powered by PhasED-Seq™, is positive. 5. Adult participants ≥18 years of age. 6. Eastern Cooperative Oncology Group (ECOG) performance status (PS) of 0 or 1. 7. Adequate hematological, renal, hepatic, pulmonary, and cardiac function 8. Non-hematologic toxicities related to prior therapy must be recovered to baseline or grade ≤1. Key Exclusion Criteria: 1. LBCL with history of central nervous system involvement, transformed from other malignancy (e.g., transformed follicular lymphoma or marginal zone lymphoma, Richter's transformation), or T-cell/histiocyte rich LBCL. 2. Prior treatment with anti-CD19 targeted therapies. 3. Anti-cancer treatment, including radiation, after end of treatment PET/CT and/or MRD testing is performed. 4. Active and clinically significant autoimmune disease. 5. Active systemic bacterial, fungal, or viral infections requiring systemic treatment. 6. History of another primary malignancy or bone marrow disorder (e.g., myelofibrosis, smoldering multiple myeloma) within 3 years prior to enrollment.

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Conditions

The condition(s) this trial relates to.

diffuse large B-cell lymphoma large B-cell lymphoma Neoplasm, Residual

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Large B-cell lymphoma

How to take part

Only the study team decides who joins. These are the ways to reach them.

  1. The study's own enquiry address

    This study publishes an address for enquiries. See it below .

  2. The places running it

    82 sites in 4 countries. The list below names each one and where it is.

  3. The official record

    ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.

    Open the record ↗

  4. A doctor treating you

    A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.

Contacts and locations

Study contacts

  • Contact

    Email: •••••@•••••

Locations

  • Advent Health Cancer Institute

    RECRUITING

    Orlando, Florida, 32804, United States

  • Ajou University Hospital

    RECRUITING

    Suwon, Gyeonggi-do, 16499, South Korea

  • Alta Bates Summit Medical Center

    RECRUITING

    Berkeley, California, 94704, United States

  • Arthur JE Child Comprehensive Cancer Centre

    RECRUITING

    Calgary, Alberta, T2N 5G2, Canada

  • Asan Medical Center

    RECRUITING

    Seoul, Seoul, 05505, South Korea

  • Astera Cancer Care

    RECRUITING

    East Brunswick, New Jersey, 08816, United States

  • Augusta University Georgia Cancer Center

    RECRUITING

    Augusta, Georgia, 30912, United States

  • Austin Health

    RECRUITING

    Heidelberg, Victoria, 3084, Australia

  • Avera Cancer Institute

    RECRUITING

    Sioux Falls, South Dakota, 57105, United States

  • Banner MD Anderson Cancer Center

    RECRUITING

    Gilbert, Arizona, 85234, United States

  • Beth Israel Deaconess Medical Center

    RECRUITING

    Boston, Massachusetts, 02215, United States

  • CHUM - University of Montreal Hospital Centre

    RECRUITING

    Montreal, Quebec, H2X 0A9, Canada

  • Cedars-Sinai Medical Center

    RECRUITING

    Los Angeles, California, 90048, United States

  • Centre Integre Universitaire de Sante et Services Sociaux de L'Est de I'lle de Montreal / installation Hopital Maisonneuve-Rosemont

    RECRUITING

    Montreal, Quebec, H1T 2M4, Canada

  • Chonnam National University, Hwasun Hospital

    RECRUITING

    Hwasun, Jeollanam-do, 58128, South Korea

  • City of Hope

    RECRUITING

    Duarte, California, 91010, United States

  • Cleveland Clinic

    RECRUITING

    Cleveland, Ohio, 44195, United States

  • Columbia University Irving Medical Center and New York-Presbyterian Hospital

    RECRUITING

    New York, New York, 10032, United States

  • Duke Blood Cancer Center

    RECRUITING

    Durham, North Carolina, 27705, United States

  • Fort Wayne Medical Oncology and Hematology

    RECRUITING

    Fort Wayne, Indiana, 46804, United States

  • Fox Chase Cancer Center

    RECRUITING

    Philadelphia, Pennsylvania, 19111, United States

  • Fred Hutchinson Cancer Center

    RECRUITING

    Seattle, Washington, 98109, United States

  • Genesis Cancer and Blood Institute

    RECRUITING

    Hot Springs, Arkansas, 71913, United States

  • Hollywood Private Hospital

    RECRUITING

    Nedlands, Western Australia, 6009, Australia

  • Hopital de'L'Enfant-Jesus

    RECRUITING

    Québec, Quebec, G1R 2J6, Canada

  • Huntsman Cancer Institute, University of Utah

    RECRUITING

    Salt Lake City, Utah, 84112, United States

  • IU Simon Comprehensive Cancer Center

    RECRUITING

    Indianapolis, Indiana, 46202, United States

  • Icon Cancer Centre Wesley

    RECRUITING

    Auchenflower, Queensland, 4066, Australia

  • Indiana Blood and Marrow Transplantation

    RECRUITING

    Indianapolis, Indiana, 46237, United States

  • Intermountain Health LDS Hospital

    RECRUITING

    Salt Lake City, Utah, 84142, United States

  • John Theurer Cancer Center

    RECRUITING

    Hackensack, New Jersey, 07601, United States

  • MD Anderson Cancer Center

    RECRUITING

    Houston, Texas, 77030, United States

  • Massachusetts General Hospital

    RECRUITING

    Boston, Massachusetts, 02114, United States

  • MedStar Georgetown University Hospital

    RECRUITING

    Washington D.C., District of Columbia, 20007, United States

  • Medical Oncology Hematology Consultants

    RECRUITING

    Newark, Delaware, 19713, United States

  • Miami Cancer Institute at Baptist Health, Inc.

    RECRUITING

    Miami, Florida, 33176, United States

  • MidAmerica Cancer Care

    RECRUITING

    Kansas City, Missouri, 64132, United States

  • Moffitt Cancer Center

    RECRUITING

    Tampa, Florida, 33612, United States

  • Monash Health

    RECRUITING

    Clayton, Victoria, 3168, Australia

  • National Cancer Center

    RECRUITING

    Goyang-si, Gyeonggi-do, 10408, South Korea

  • Northwestern University - Feinberg School of Medicine

    RECRUITING

    Chicago, Illinois, 60611, United States

  • Norton Cancer Institute

    RECRUITING

    Louisville, Kentucky, 40207, United States

  • Novant Health Cancer Institute- Hematology

    RECRUITING

    Charlotte, North Carolina, 28204, United States

  • Oncology Associates of Oregon

    RECRUITING

    Eugene, Oregon, 97401, United States

  • Oncology Hematology Care - Kenwood

    RECRUITING

    Cincinnati, Ohio, 45236, United States

  • Oregon Health and Science University

    RECRUITING

    Portland, Oregon, 97239, United States

  • Orlando Health Cancer Institute

    RECRUITING

    Orlando, Florida, 32806, United States

  • Princess Margaret Cancer Centre - University Health Network

    RECRUITING

    Toronto, Ontario, M5G 1Z5, Canada

  • Pusan National University Hospital

    RECRUITING

    Seogu, Busan, South Korea, South Korea

  • Queen Elizabeth II Health Sciences Centre

    RECRUITING

    Halifax, Nova Scotia, B3H 2Y9, Canada

  • Rocky Mountain Cancer Centers

    RECRUITING

    Lone Tree, Colorado, 80124, United States

  • Royal Hobart Hospital

    RECRUITING

    Hobart, Tasmania, 7000, Australia

  • Rush University Medical Center

    RECRUITING

    Chicago, Illinois, 60612, United States

  • Rutgers Cancer Institute of New Jersey

    RECRUITING

    New Brunswick, New Jersey, 08901, United States

  • Samsung Medical Center

    RECRUITING

    Seoul, Seoul, 06351, South Korea

  • Seoul National University

    RECRUITING

    Seoul, Seoul, 03080, South Korea

  • Severance Hospital, Yonsei University Health System

    RECRUITING

    Seoul, Seoul, 03722, South Korea

  • St. Vincent's Hospital Melbourne

    RECRUITING

    Fitzroy, Victoria, 3065, Australia

  • Swedish Cancer Institute

    RECRUITING

    Seattle, Washington, 98104, United States

  • Texas Oncology - Central South

    RECRUITING

    Austin, Texas, 78705, United States

  • Texas Oncology - Dallas Fort Worth

    RECRUITING

    Dallas, Texas, 75203, United States

  • Texas Oncology - Tyler

    RECRUITING

    Tyler, Texas, 75702, United States

  • Texas Transplant Institute

    RECRUITING

    San Antonio, Texas, 78229, United States

  • The Catholic University of Korea, Yeouido St. Mary's Hospital

    RECRUITING

    Seoul, Seoul, 07345, South Korea

  • The Center for Cancer and Blood Disorders

    RECRUITING

    Bethesda, Maryland, 20817, United States

  • The University of Kansas Hospital

    ACTIVE_NOT_RECRUITING

    Kansas City, Kansas, 66205, United States

  • University of California, Davis Comprehensive Cancer Center

    RECRUITING

    Sacramento, California, 95817, United States

  • University of California, Los Angeles

    RECRUITING

    Los Angeles, California, 90095, United States

  • University of California, San Diego

    RECRUITING

    San Diego, California, 92037, United States

  • University of California, San Francisco

    RECRUITING

    San Francisco, California, 94143, United States

  • University of Cincinnati Medical Center

    RECRUITING

    Cincinnati, Ohio, 45267, United States

  • University of Kentucky Medical Center

    RECRUITING

    Lexington, Kentucky, 40536, United States

  • University of Louisville Health Brown Cancer Center

    RECRUITING

    Louisville, Kentucky, 40202, United States

  • University of Maryland Greenebaum Comprehensive Cancer Center

    RECRUITING

    Baltimore, Maryland, 21201, United States

  • University of Minnesota Medical Center

    RECRUITING

    Minneapolis, Minnesota, 55455, United States

  • University of Missouri - Ellis Fischel Cancer Center

    RECRUITING

    Columbia, Missouri, 65212, United States

  • University of Rochester Medical Center

    RECRUITING

    Rochester, New York, 14642, United States

  • University of Virginia

    RECRUITING

    Charlottesville, Virginia, 22903, United States

  • Vanderbilt University Medical Center

    RECRUITING

    Nashville, Tennessee, 37232, United States

  • Virginia Cancer Specialists

    RECRUITING

    Fairfax, Virginia, 22031, United States

  • Virginia Oncology Associates - Norfolk

    RECRUITING

    Norfolk, Virginia, 23502, United States

  • Washington University School of Medicine - Siteman Cancer Center

    RECRUITING

    St Louis, Missouri, 63110, United States

  • West Penn Hospital

    RECRUITING

    Pittsburgh, Pennsylvania, 15224, United States

More trials for these conditions

Other studies related to the condition(s) this trial covers.