New CAR t therapy targets hidden lymphoma cells after initial treatment

NCT ID NCT06500273

Recruiting now Disease control Sponsor: Allogene Therapeutics Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jul 31, 2026 · Updated 4 times

Summary

This study tests a new cell therapy called cemacabtagene ansegedleucel (cema-cel) in adults with large B-cell lymphoma who still have tiny amounts of cancer cells (minimal residual disease) after finishing their first standard treatment. About 250 participants will be randomly assigned to receive either cema-cel or standard monitoring. The goal is to see if this therapy can prevent the cancer from coming back.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Get updates

Get notified about this study

Our safety recommendation!

By submitting, you agree to our Terms of use

Conditions

The condition(s) this trial relates to.

diffuse large B-cell lymphoma large B-cell lymphoma Neoplasm, Residual

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

LARGE B-CELL LYMPHOMA

Contacts and locations

Show contact details

Study contacts

Contact

Email: •••••@•••••

Locations

Advent Health Cancer Institute
RECRUITING

Orlando, Florida, 32804, United States
Alta Bates Summit Medical Center
RECRUITING

Berkeley, California, 94704, United States
Arthur JE Child Comprehensive Cancer Centre
RECRUITING

Calgary, Alberta, T2N 5G2, Canada
Asan Medical Center
RECRUITING

Seoul, Seoul, 05505, South Korea
Astera Cancer Care
RECRUITING

East Brunswick, New Jersey, 08816, United States
Augusta University Georgia Cancer Center
RECRUITING

Augusta, Georgia, 30912, United States
Austin Health
RECRUITING

Heidelberg, Victoria, 3084, Australia
Avera Cancer Institute
RECRUITING

Sioux Falls, South Dakota, 57105, United States
Banner MD Anderson Cancer Center
RECRUITING

Gilbert, Arizona, 85234, United States
Beth Israel Deaconess Medical Center
RECRUITING

Boston, Massachusetts, 02215, United States
CHUM - University of Montreal Hospital Centre
RECRUITING

Montreal, Quebec, H2X 0A9, Canada
Cedars-Sinai Medical Center
RECRUITING

Los Angeles, California, 90048, United States
Centre Integre Universitaire de Sante et Services Sociaux de L'Est de I'lle de Montreal / installation Hopital Maisonneuve-Rosemont
RECRUITING

Montreal, Quebec, H1T 2M4, Canada
Chonnam National University, Hwasun Hospital
RECRUITING

Hwasun, Jeollanam-do, 58128, South Korea
City of Hope
RECRUITING

Duarte, California, 91010, United States
Cleveland Clinic
RECRUITING

Cleveland, Ohio, 44195, United States
Columbia University Irving Medical Center and New York-Presbyterian Hospital
RECRUITING

New York, New York, 10032, United States
Duke Blood Cancer Center
RECRUITING

Durham, North Carolina, 27705, United States
Fort Wayne Medical Oncology and Hematology
RECRUITING

Fort Wayne, Indiana, 46804, United States
Fox Chase Cancer Center
RECRUITING

Philadelphia, Pennsylvania, 19111, United States
Fred Hutchinson Cancer Center
RECRUITING

Seattle, Washington, 98109, United States
Genesis Cancer and Blood Institute
RECRUITING

Hot Springs, Arkansas, 71913, United States
Hollywood Private Hospital
RECRUITING

Nedlands, Western Australia, 6009, Australia
Hopital de'L'Enfant-Jesus
RECRUITING

Québec, Quebec, G1R 2J6, Canada
Huntsman Cancer Institute, University of Utah
RECRUITING

Salt Lake City, Utah, 84112, United States
IU Simon Comprehensive Cancer Center
RECRUITING

Indianapolis, Indiana, 46202, United States
Icon Cancer Centre Wesley
RECRUITING

Auchenflower, Queensland, 4066, Australia
Indiana Blood and Marrow Transplantation
RECRUITING

Indianapolis, Indiana, 46237, United States
Intermountain Health LDS Hospital
RECRUITING

Salt Lake City, Utah, 84142, United States
John Theurer Cancer Center
RECRUITING

Hackensack, New Jersey, 07601, United States
MD Anderson Cancer Center
RECRUITING

Houston, Texas, 77030, United States
Massachusetts General Hospital
RECRUITING

Boston, Massachusetts, 02114, United States
MedStar Georgetown University Hospital
RECRUITING

Washington D.C., District of Columbia, 20007, United States
Medical Oncology Hematology Consultants
RECRUITING

Newark, Delaware, 19713, United States
Miami Cancer Institute at Baptist Health, Inc.
RECRUITING

Miami, Florida, 33176, United States
MidAmerica Cancer Care
RECRUITING

Kansas City, Missouri, 64132, United States
Moffitt Cancer Center
RECRUITING

Tampa, Florida, 33612, United States
Monash Health
RECRUITING

Clayton, Victoria, 3168, Australia
National Cancer Center
RECRUITING

Goyang-si, Gyeonggi-do, 10408, South Korea
Northwestern University - Feinberg School of Medicine
RECRUITING

Chicago, Illinois, 60611, United States
Norton Cancer Institute
RECRUITING

Louisville, Kentucky, 40207, United States
Novant Health Cancer Institute- Hematology
RECRUITING

Charlotte, North Carolina, 28204, United States
Oncology Associates of Oregon
RECRUITING

Eugene, Oregon, 97401, United States
Oncology Hematology Care - Kenwood
RECRUITING

Cincinnati, Ohio, 45236, United States
Oregon Health and Science University
RECRUITING

Portland, Oregon, 97239, United States
Orlando Health Cancer Institute
RECRUITING

Orlando, Florida, 32806, United States
Princess Margaret Cancer Centre - University Health Network
RECRUITING

Toronto, Ontario, M5G 1Z5, Canada
Pusan National University Hospital
RECRUITING

Seogu, Busan, South Korea, South Korea
Queen Elizabeth II Health Sciences Centre
RECRUITING

Halifax, Nova Scotia, B3H 2Y9, Canada
Rocky Mountain Cancer Centers
RECRUITING

Denver, Colorado, 80218, United States
Royal Hobart Hospital
RECRUITING

Hobart, Tasmania, 7000, Australia
Rush University Medical Center
RECRUITING

Chicago, Illinois, 60612, United States
Rutgers Cancer Institute of New Jersey
RECRUITING

New Brunswick, New Jersey, 08901, United States
Samsung Medical Center
RECRUITING

Seoul, Seoul, 06351, South Korea
Seoul National University
RECRUITING

Seoul, Seoul, 03080, South Korea
Severance Hospital, Yonsei University Health System
RECRUITING

Seoul, Seoul, 03722, South Korea
St. Vincent's Hospital Melbourne
RECRUITING

Fitzroy, Victoria, 3065, Australia
Swedish Cancer Institute
RECRUITING

Seattle, Washington, 98104, United States
Texas Oncology - Central South
RECRUITING

Austin, Texas, 78705, United States
Texas Oncology - Dallas Fort Worth
RECRUITING

Dallas, Texas, 75246, United States
Texas Oncology - Tyler
RECRUITING

Tyler, Texas, 75702, United States
Texas Transplant Institute
RECRUITING

San Antonio, Texas, 78229, United States
The Catholic University of Korea, Yeouido St. Mary's Hospital
RECRUITING

Seoul, Seoul, 07345, South Korea
The Center for Cancer and Blood Disorders
RECRUITING

Bethesda, Maryland, 20817, United States
The University of Kansas Hospital
ACTIVE_NOT_RECRUITING

Kansas City, Kansas, 66205, United States
University of California, Davis Comprehensive Cancer Center
RECRUITING

Sacramento, California, 95817, United States
University of California, Los Angeles
RECRUITING

Los Angeles, California, 90095, United States
University of California, San Diego
RECRUITING

San Diego, California, 92037, United States
University of California, San Francisco
RECRUITING

San Francisco, California, 94143, United States
University of Cincinnati Medical Center
RECRUITING

Cincinnati, Ohio, 45267, United States
University of Kentucky Medical Center
RECRUITING

Lexington, Kentucky, 40536, United States
University of Louisville Health Brown Cancer Center
RECRUITING

Louisville, Kentucky, 40202, United States
University of Maryland Greenebaum Comprehensive Cancer Center
RECRUITING

Baltimore, Maryland, 21201, United States
University of Minnesota Medical Center
RECRUITING

Minneapolis, Minnesota, 55455, United States
University of Missouri - Ellis Fischel Cancer Center
RECRUITING

Columbia, Missouri, 65212, United States
University of Rochester Medical Center
RECRUITING

Rochester, New York, 14642, United States
University of Virginia
RECRUITING

Charlottesville, Virginia, 22903, United States
Vanderbilt University Medical Center
RECRUITING

Nashville, Tennessee, 37232, United States
Virginia Cancer Specialists
RECRUITING

Fairfax, Virginia, 22031, United States
Virginia Oncology Associates - Norfolk
RECRUITING

Norfolk, Virginia, 23502, United States
Washington University School of Medicine - Siteman Cancer Center
RECRUITING

St Louis, Missouri, 63110, United States
West Penn Hospital
RECRUITING

Pittsburgh, Pennsylvania, 15224, United States

More trials for these conditions

Other studies related to the condition(s) this trial covers.