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30,000-Person study seeks to unmask hidden heart failure

NCT ID NCT07493590

Knowledge-focused Sponsor: Herlev and Gentofte Hospital Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting This study
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This observational study will enroll 30,000 adults in Denmark to better understand heart failure with preserved ejection fraction (HFpEF), a condition where the heart pumps normally but is too stiff to fill properly. Researchers will use blood tests, heart imaging, and health records to find early signs of the disease and identify different patient subtypes. No treatments are given; the goal is to improve detection and knowledge.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

What this could lead to
If successful, this study could lead to better ways to detect HFpEF early and identify different types of the disease, helping doctors personalize care.
What could go wrong
This is an observational study, not a treatment trial. It will not test any new drug or therapy, so it cannot directly improve outcomes for participants.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Participants

About 30,000 people

The number the study aims to enrol. It can still change while the study runs.

Expected to start

Apr 2026

An estimate. Start dates often move.

Expected to finish

Apr 2035

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Who is studied

Adult individuals across Denmark with risk factors for heart failure with preserved ejection fraction (HFpEF). Participants will be identified through nationwide registries and invited via the Danish secure e-mail system (e-Boks).

Ages

18 to 90 years

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Patients \>60 years with ≥1 risk factor, OR * Patients \>50 years with ≥2 risk factors * Hypertension * Type 1 or 2 diabetes * Chronic kidney disease (eGFR \<60 mL/min/1.73 m²) * Previous cardiotoxic drug exposure * atrial fibrillation * Ischemic heart disease * Previous heart valve surgery/intervention * Body mass index \>30 kg/m² (self-reported) * Use of ≥40 mg furosemide * Obstructive sleep apnea * Non-alcoholic fatty liver disease Exclusion Criteria: * Cancer \<1 year * Dialysis * COPD and O2 * Nursing home * Age \>90 years * Dementia * Known dilated cardiomyopathy * Prior organ-transplantation * Amyloidosis

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Conditions

The condition(s) this trial relates to.

cardiovascular disorder diastolic heart failure heart failure

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Heart failure with preserved ejection fraction (hfpef)

How to take part

Only the study team decides who joins. These are the ways to reach them.

  1. The places running it

    1 site. The list below names each one and where it is.

  2. The official record

    ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.

    Open the record ↗

  3. A doctor treating you

    A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.

Contacts and locations

Locations

  • Herlev and Gentofte Hospital

    Copenhagen, Denmark

More trials for these conditions

Other studies related to the condition(s) this trial covers.