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Could your genes hold the key to cancer risk? scientists investigate families

NCT ID NCT04185935

Knowledge-focused Sponsor: City of Hope Medical Center Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now This study
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 29, 2026 · Last updated Jun 30, 2026 · Updated 1 time

Summary

This study looks at genetic and behavioral factors that might influence cancer development and outcomes. It involves people with a personal or family history of cancer, who provide samples like blood, saliva, or urine. The goal is to better understand inherited cancer risks and find biomarkers for future studies.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

What this could lead to
If successful, this research could identify genetic markers that predict cancer risk, helping to guide future screening and prevention strategies.
What could go wrong
This is an observational study, not a treatment trial. It may not directly benefit participants, and findings may take years to translate into clinical practice.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Participants

About 999,999 people

The number the study aims to enrol. It can still change while the study runs.

Started

Apr 1997

Expected to finish

Aug 2033

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Who is studied

Participants with a family history of cancer

Ages

Children (under 18), adults (18 to 64) and older adults (65 and over)

Sex

Anyone

Healthy volunteers

Accepted

You do not need to have the condition being studied to take part.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Individuals must have a personal history of cancer and/or a family history of cancer suggestive of the presence of an inherited predisposition. This inherited predisposition might manifest as: * Young age cancer diagnosis * Multiple primary neoplasms in affected member * The presence of rare tumor types in the family * Congenital malformations * Any other family clustering of cancer * Any other cancer-predisposing genetic diseases/conditions * Individuals may also be eligible by participation in the City of Hope Cancer Screening \& Prevention Program Network (CSPPN) clinical service or on the basis of membership in a group known or suspected to have an increased risk of carrying a genetic alteration or of sustaining a particular exposure that would place that at increased risk of cancer. (Examples would include members of occupational cohorts like asbestos workers, individuals with multiple dysplastic nevi in the absence of a family history of cancer, and individuals descended from a particular tribe in the American Southwest who have an increased incidence of a rare genetic alteration associated with an increased risk of a specific cancer.) * Individuals and families may be referred to us in a number of different ways. After initial contact is made with a individual or family by family studies personnel; an individual within the bloodline will be identified as the historian. There may be more than one historian within a family * At least one historian must be wiling to provide information or access as needed to contact appropriate family members for documentation of cancer and for consent. An individual is considered to be eligible to participate if they criteria; contact with relatives is not always indicated * Individuals who are under 18 are eligible for study if they meet the criteria. Consent for participation must be given by a legal guardian or parent * Deceased patients may be included in the study. Public records, such as death certificates, can be used to confirm information from individuals or family members. If medical records are needed, consent for these records will be obtained from the deceased's next of kin. Next of kin refers to the following hierarchy of relatives; spouse, offspring, parents, and siblings. (Any further use of next of kin in this protocol should relate back to this hierarchy.) Archived tissue samples, such as pathology blocks or snap frozen tumor from a pathology department tumor bank (discard specimens) may be used for genetic research Exclusion Criteria: * A family may be ineligible for study if the historian will not allow access to anyone within the family and thus, the accuracy of the family history cannot be established

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Conditions

The condition(s) this trial relates to.

cancer neoplasm

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Malignant neoplasm

How to take part

Only the study team decides who joins. These are the ways to reach them.

  1. The places running it

    42 sites in 5 countries. The list below names each one and where it is.

  2. The official record

    ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.

    Open the record ↗

  3. A doctor treating you

    A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.

Contacts and locations

Locations

  • Aultman Health Foundation

    RECRUITING

    Canton, Ohio, 44710, United States

  • Baylor College of Medicine/Dan L Duncan Comprehensive Cancer Center

    NOT_YET_RECRUITING

    Houston, Texas, 77030, United States

  • Cancer Center of Santa Barbara

    RECRUITING

    Santa Barbara, California, 93105, United States

  • Cheyenne Regional Medical Center-West

    RECRUITING

    Cheyenne, Wyoming, 82001, United States

  • City of Hope Medical Center

    RECRUITING

    Duarte, California, 91010, United States

  • Clinica del Country

    RECRUITING

    Bogotá, Cundinamarca, Colombia

  • Covenant Medical Center

    RECRUITING

    Lubbock, Texas, 79410, United States

  • Doctor's Hospital of Laredo

    RECRUITING

    Laredo, Texas, 78041, United States

  • Frederick Oncology Hematology Associates

    RECRUITING

    Frederick, Maryland, 21702, United States

  • Health Quest Medical Practice PC-Cardio Thoracic

    RECRUITING

    Poughkeepsie, New York, 12601, United States

  • Holy Cross Hospital

    RECRUITING

    Fort Lauderdale, Florida, 33308, United States

  • Hunterdon Medical Center

    RECRUITING

    Flemington, New Jersey, 08822, United States

  • Instituto Nacional de Enfermedades Neoplasicas

    RECRUITING

    Lima, Lima 34, Peru

  • Instituto de Cancerologia Las Americas

    RECRUITING

    Medellín, Colombia

  • John H Stroger Jr Hospital of Cook County

    RECRUITING

    Chicago, Illinois, 60612, United States

  • John Muir Medical Center-Concord Campus

    RECRUITING

    Concord, California, 94520, United States

  • Kootenai Cancer Center

    RECRUITING

    Post Falls, Idaho, 83854, United States

  • Lovelace Medical Center-Downtown

    RECRUITING

    Albuquerque, New Mexico, 87102, United States

  • Lynn Regional Cancer Center - West

    RECRUITING

    Boca Raton, Florida, 33428, United States

  • Mercy Hospital

    RECRUITING

    Cedar Rapids, Iowa, 52403, United States

  • Monterrey Institute of Technology-TecSalud

    RECRUITING

    Nuevo León, Mexico

  • Mount Kisco Medical Group at Northern Westchester Hospital

    RECRUITING

    Mount Kisco, New York, 10549-3417, United States

  • New Mexico Oncology Hematology Consultants

    RECRUITING

    Albuquerque, New Mexico, 87109, United States

  • Paoli Memorial Hospital

    RECRUITING

    Paoli, Pennsylvania, 19301, United States

  • Presbyterian Kaseman Hospital

    RECRUITING

    Albuquerque, New Mexico, 87110, United States

  • ProHealth Waukesha Memorial Hospital

    RECRUITING

    Waukesha, Wisconsin, 53188, United States

  • Reading Hospital

    RECRUITING

    West Reading, Pennsylvania, 19611, United States

  • Rush University Medical Center

    RECRUITING

    Chicago, Illinois, 60612, United States

  • Saddleback Memorial Medical Center

    RECRUITING

    Laguna Hills, California, 92653, United States

  • Saint Agnes Hospital/Agnesian Cancer Center

    RECRUITING

    Fond du Lac, Wisconsin, 54935, United States

  • Saint Charles Health System

    RECRUITING

    Bend, Oregon, 97701, United States

  • Saint Joseph Hospital - Orange

    RECRUITING

    Orange, California, 92868, United States

  • Saint Jude Medical Center

    RECRUITING

    Fullerton, California, 92835, United States

  • Salvador Zubiran National Institute of Health Sciences and Nutrition

    RECRUITING

    Mexico City, Tlalpan, 14080, Mexico

  • Steward Saint Elizabeth's Medical Center

    RECRUITING

    Brighton, Massachusetts, 02135, United States

  • Suburban Hospital

    RECRUITING

    Bethesda, Maryland, 20814, United States

  • Sutter Cancer Centers Radiation Oncology Services-Roseville

    RECRUITING

    Roseville, California, 95661, United States

  • The Don and Sybil Harrington Cancer Center

    RECRUITING

    Amarillo, Texas, 79106, United States

  • USC / Norris Comprehensive Cancer Center

    RECRUITING

    Los Angeles, California, 90033, United States

  • University of Guadalajara

    RECRUITING

    Guadalajara, Jalisco, CP 44340, Mexico

  • University of Puerto Rico

    RECRUITING

    San Juan, 00936, Puerto Rico

  • Valleywise Comprehensive Health Center - Phoenix

    RECRUITING

    Phoenix, Arizona, 85008, United States

More trials for these conditions

Other studies related to the condition(s) this trial covers.