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Your nose knows: can smell predict seizures?

NCT ID NCT05865561

Knowledge-focused Sponsor: Fondation Ophtalmologique Adolphe de Rothschild Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now This study
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study is testing whether people with epilepsy release specific odors that can predict a seizure before it happens. Researchers will collect skin swabs from 100 adults with drug-resistant epilepsy during and between seizures. The goal is to identify the chemical 'signature' of these odors, which could one day lead to a simple, non-invasive seizure prediction tool.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
VOC sampling (skin swab)
What this could lead to
If successful, this could lead to a non-invasive way to predict seizures minutes to hours in advance, improving safety and quality of life for people with epilepsy.
What could go wrong
This is an early, small study (100 people) focused on identifying odors, not yet testing a prediction device. The results may not apply to all seizure types or people.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Participants

About 100 people

The number the study aims to enrol. It can still change while the study runs.

Started

Feb 2024

Expected to finish

Jun 2026

An estimate. End dates often move.

Lead sponsor

A research network

The lead sponsor is a research network or cooperative group.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Who is studied

The epileptics will be recruited by the neurologists from among the epileptics treated at the Institut la Teppe and the Fondation A de Rothschild Hospital who meet the selection criteria.

Ages

18 years and older

Sex

Anyone

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Person at least 18 years of age * With drug-resistant epilepsy according to the ILAE criteria * With one of the following 3 types of seizures : Focal seizures Focal seizures with secondary generalization Generalized seizures - motor or non-motor * Requiring at least 48 hours of video-EEG * Consent to participate in the study from the patient and his/her legal guardian, if applicable * Affiliated or beneficiary of a social security plan Exclusion Criteria: * Person with epilepsy benefiting from a legal protection measure other than curatorship or guardianship * Pregnant or breastfeeding woman

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Conditions

The condition(s) this trial relates to.

epilepsy

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Epilepsy

How to take part

Only the study team decides who joins. These are the ways to reach them.

  1. The places running it

    2 sites. The list below names each one and where it is.

  2. The official record

    ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.

    Open the record ↗

  3. A doctor treating you

    A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.

Contacts and locations

Locations

  • Hôpital Fondation Adolphe de Rothschild

    RECRUITING

    Paris, 75019, France

  • Institut La Teppe

    RECRUITING

    Tain-l'Hermitage, 26600, France

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