Artery plaque scans may reveal hidden stroke risk
NCT ID NCT06404242
First seen Aug 06, 2026 · Last updated Aug 07, 2026 · Updated 1 time
Summary
This study investigates whether high-resolution MRI can identify dangerous plaque features in the middle cerebral artery that might predict a second stroke. Researchers will follow 75 patients who had a first stroke due to significant narrowing of this artery, tracking which plaque characteristics are linked to recurrent strokes in the same area. The goal is to see if this imaging approach can help guide more personalized treatment based on individual risk.
What this could mean
Our plain-language read of the trial. This is informational only, not medical advice or a prediction.
- Active substance
- High-resolution vessel wall magnetic resonance imaging (HR-MRI)
- What this could lead to
- If successful, this could help doctors identify stroke patients at higher risk of another stroke and tailor treatments more precisely.
- What could go wrong
- This is a small, observational study, so results may not apply to all patients. The imaging technique may not reliably predict recurrent strokes in every case.
This is an AI summary of the original study and may miss details. Read our disclaimer.
Study facts
What this study's own registry entry says, in plain language.
- Participants
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About 75 people
The number the study aims to enrol. It can still change while the study runs.
- Started
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May 2024
- Expected to finish
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Dec 2026
An estimate. End dates often move.
- Lead sponsor
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Other sponsor
The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.
Who can take part
This study's own entry requirements. Only the study team can say for certain whether you qualify.
Who is studied
The investigators would include patients who had ischemic stroke due to middle cerebral artery (MCA) stenosis (\>50%)
- Ages
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45 to 100 years
- Sex
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Anyone
- Healthy volunteers
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Not accepted
This study is not open to healthy volunteers. The entry requirements below say who it is open to.
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Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.
Inclusion Criteria: * Patients who had a first-time ischemic stroke due to MCA atherosclerosis stenosis more than 50% and admitted to our hospital within 7 days after onset. * Patients are more than 45 years old. * Patients had HR-MRI and have done the full stroke workup (including carotid duplex scanning, fasting lipid profile, Holter ECG 24 hours, cardiac ultrasound,...) Exclusion Criteria: * Patients also have stenosis of the carotid artery (more than 50%) or occulsion on the same side of ischemic stroke * Patients also have an ischemic stroke in territories other than MCA territory. * Patients had any characteristics that suggested other causes for their stenosis, including moyamoya, dissection, and inflammation on their MRI and HR-MRI. * Patients with evidence suggestive of cardioembolism (Atrial fibrillation, decreased EF \<50%, recent heart attack in 3 weeks, rheumatic valvular heart disease, dilated cardiopathy, sick sinus syndrome, infective endocarditis). * Any signs suggestive other causes (non atherosclerosis etiology), including autoimmune disease or increased coagulation state. * Patients with severe concomitant disease could affect the 6-month follow-up of the patients.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
How to take part
Only the study team decides who joins. These are the ways to reach them.
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The places running it
1 site. The list below names each one and where it is.
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The official record
ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.
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A doctor treating you
A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.
Contacts and locations
Locations
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University Medical Center Ho Chi Minh City
RECRUITINGHo Chi Minh City, Ho Chi Minh City, 70000, Vietnam
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