Could a simple warning before anesthesia actually lessen the pain?
NCT ID NCT05886972
First seen Jul 27, 2026 · Last updated Jul 28, 2026 · Updated 1 time
Summary
Propofol, a common anesthesia drug, often causes pain when injected — affecting up to 90% of patients. This trial tests whether simply telling patients beforehand that the injection might hurt can reduce how often and how severely that pain occurs. Researchers will compare pain scores between informed and uninformed female patients aged 20–40 undergoing elective surgery.
What this could mean
Our plain-language read of the trial. This is informational only, not medical advice or a prediction.
- Active substance
- informing patients about possible injection pain before anesthesia
- What this could lead to
- If it works, a simple conversation before anesthesia could reduce pain and anxiety for millions of people undergoing surgery.
- What could go wrong
- This is a small, early-phase trial in healthy young women only. Results may not apply to men, older adults, or people with health conditions. Telling patients about possible pain could also increase anxiety in some people.
This is an AI summary of the original study and may miss details. Read our disclaimer.
Study facts
What this study's own registry entry says, in plain language.
- Phase
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Phase 2
Tests whether the treatment actually works, and watches for side effects, in a larger group.
- Participants
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210 people
The number who actually took part.
- Started
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Jul 2023
- Finished
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Nov 2023
- Lead sponsor
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Other sponsor
The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.
Who can take part
This study's own entry requirements. Only the study team can say for certain whether you qualify.
- Ages
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20 to 40 years
- Sex
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Female participants only
- Healthy volunteers
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Accepted
You do not need to have the condition being studied to take part.
Show the full entry requirements Hide the full entry requirements
Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.
Inclusion Criteria: * Female patients aged 20 to 40 years of The American Society of Anesthesiologists (ASA) I-II , who will be undergoing elective surgery under general anesthesia Exclusion Criteria: * patient with mental illness, poor understanding or difficulty in communication or pain assessment . * any organ dysfunction, neurological disease, diabetes mellitus . * patient with high education level (patient with education level after high secondary school) . * patient with Body Mass Index (BMI) \< 18 or \> 30 * allergy to the study drugs . * history of chronic pain or those taking regular analgesics, anti-inflammatory drugs pre-operatively . history of drug abuse and other contraindication for lidocaine such as severe bradycardia, Wolf-Parkinson-White syndrome, and other tachyarrhythmias .
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As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
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Mahmoud Hussein Bahr
Beni-suef, Cairo Governorate, 62521, Egypt