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Simple bedside test may help ICU doctors safely reduce blood pressure drugs

NCT ID NCT03455738

Knowledge-focused Sponsor: Centre Hospitalier Universitaire, Amiens Source: ClinicalTrials.gov ↗

What the study statuses mean

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Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed This study
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 26, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study looked at whether a non-invasive monitoring tool (called dynamic arterial elastance, or Eadyn) can predict how a patient's blood pressure will respond when doctors reduce the dose of norepinephrine, a drug used to raise blood pressure. The study included 35 ICU patients with vasoplegia (a condition of very low blood pressure). Researchers measured Eadyn before and after lowering the norepinephrine dose. The goal was to see if Eadyn could identify which patients would have a significant drop in blood pressure, helping doctors make safer decisions.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

What this could lead to
If successful, this could help doctors safely reduce norepinephrine in ICU patients, potentially shortening treatment and avoiding unnecessary medication.
What could go wrong
This is a small, early study (35 patients) testing a monitoring method, not a treatment. The measure may be less accurate in patients on norepinephrine, and results may not apply to all ICU settings.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Participants

35 people

The number who actually took part.

Started

Oct 2016

Finished

Apr 2017

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Who is studied

one group Patients with vasoplegic syndrome

Ages

18 years and older

Sex

Anyone

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: Inclusion criteria were all consecutive patients with a diagnosis of vasoplegic syndrome, treated with norepinephrine, for whom the attending physician decided to decrease the norepinephrine dosage. The vasoplegic syndrome was defined as persistent arterial hypotension with normal or high cardiac output and low systemic vascular resistance Exclusion Criteria: Exclusion criteria were patients treated with epinephrine and/or dobutamine, arrhythmia, intra-abdominal hypertension and patients younger than 18 years.

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Conditions

The condition(s) this trial relates to.

Vasoplegia

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Vasoplegia syndrome

Contacts and locations

Locations

  • CHU Amiens-Picardie

    Amiens, 80054, France

More trials for these conditions

Other studies related to the condition(s) this trial covers.