Did two years of eating less slow aging? scientists revisit CALERIE participants
NCT ID NCT05651620
First seen Jun 27, 2026 · Last updated Jun 27, 2026
Summary
This study checks in on people who took part in a major calorie restriction trial over a decade ago. Researchers want to see if the two-year diet change left any lasting effects on biological age and overall health. About 216 former participants will have their health measured to look for long-term benefits.
What this could mean
Our plain-language read of the trial. This is informational only, not medical advice or a prediction.
- Active substance
- calorie restriction
- What this could lead to
- If successful, this could show that a period of calorie restriction has lasting benefits on aging and health, potentially guiding future anti-aging strategies.
- What could go wrong
- This is an observational follow-up, not a new treatment trial. Results may be limited by the original study's size and participant characteristics, and cannot prove cause and effect.
This is an AI summary of the original study and may miss details. Read our disclaimer.
Study facts
What this study's own registry entry says, in plain language.
- Participants
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About 216 people
The number the study aims to enrol. It can still change while the study runs.
- Started
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Apr 2023
- Expected to finish
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Jan 2028
An estimate. End dates often move.
- Lead sponsor
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Other sponsor
The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.
Who can take part
This study's own entry requirements. Only the study team can say for certain whether you qualify.
Who is studied
All CALERIE participants, except those who are deceased, are known not to qualify, or did not start their allocated group (CR intervention or ad libitum control) (n = 4), have been identified as potential subjects (n = 216) in the CALERIE Legacy Study. The demographic profile of this study is expected to be similar to that of the CALERIE trial, which was 70.4% female. Healthy individuals without obesity of either sex and all race and ethnic groups were eligible to participate in the CALERIE trial. However, due to safety concerns, pregnant women were excluded, and to avoid confounding from peri- and post-menopausal status, the upper age limit for women was 47 years. Upon enrollment, CALERIE participants were 21-50y, 77.3% White, 12% Black, and 10.7% other; ethnicity was 97% non-Hispanic.
- Ages
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33 to 70 years
- Sex
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Anyone
- Healthy volunteers
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Accepted
You do not need to have the condition being studied to take part.
Show the full entry requirements Hide the full entry requirements
Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.
Inclusion Criteria: * Enrolled in the CALERIE trial and started their allocated group (CR intervention or ad libitum control condition) * Willing and able to attend one of the clinical sites for an in-person visit and provide informed consent Exclusion Criteria: * Pregnant women * Women less than 12 months postpartum * Documented note from the CALERIE trial indicating that the subject should not be contacted or requested not to be contacted for future research * Diagnosed active cancer or terminal illness
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Genom att skicka in godkänner du våra Användarvillkor
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
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Jean Mayer USDA Human Nutrition Research Center on Aging at Tufts University
Boston, Massachusetts, 02111, United States
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Pennington Biomedical Research Center
Baton Rouge, Louisiana, 70808, United States
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Washington University School of Medicine
St Louis, Missouri, 63110-1010, United States