Could a simple mouthwash keep your Mouth's bacteria healthy?
NCT ID NCT04973358
First seen Jun 27, 2026 · Last updated Jun 27, 2026
Summary
This study investigates whether a specific mouthwash (buccotherm) helps maintain a balanced and healthy community of bacteria in the mouth, compared to a placebo mouthwash. Healthy adults with at least 20 natural teeth will use the mouthwash twice daily for 14 weeks. Researchers will use advanced DNA sequencing to track changes in the types and diversity of oral bacteria, aiming to see if the mouthwash supports a healthy microbiome rather than disrupting it.
What this could mean
Our plain-language read of the trial. This is informational only, not medical advice or a prediction.
- Active substance
- buccotherm mouthwash
- What this could lead to
- If successful, this could show that certain mouthwashes support a healthy oral microbiome, potentially reducing risks of cavities, gum disease, and other health issues linked to oral bacteria.
- What could go wrong
- This is an early-stage study with a small number of participants. The mouthwash may not meaningfully change the microbiome compared to placebo, and any benefits for disease prevention remain speculative.
This is an AI summary of the original study and may miss details. Read our disclaimer.
Study facts
What this study's own registry entry says, in plain language.
- Phase
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Not a phased trial
Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.
- Expected to start
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Jan 2022
An estimate. Start dates often move.
- Expected to finish
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Jan 2024
An estimate. End dates often move.
- Lead sponsor
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Other sponsor
The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.
Who can take part
This study's own entry requirements. Only the study team can say for certain whether you qualify.
- Ages
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18 years and older
- Sex
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Anyone
- Healthy volunteers
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Accepted
You do not need to have the condition being studied to take part.
Show the full entry requirements Hide the full entry requirements
Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.
Inclusion Criteria: * 18 years of age or older: * with at least 20 permanent natural teeth, excluding crowns; * affiliated to a social security system; * having received information about the protocol and having given their free, informed and written consent. Exclusion Criteria: * with periodontitis in the month prior to inclusion; * with significant carious lesions deeply modifying the oral microbiota in the month prior to inclusion; * having undergone oral surgical treatment within 3 months prior to inclusion; * wearing orthodontic appliances; * having undergone periodontal procedures in the month prior to inclusion; * suffering from severe chronic pathologies deemed incompatible with study entry; * allergic to one of the swab components; * allergic to any of the components of the BUCCOTHERM mouthwash or the placebo; * on drugs that may cause gingival hypertrophy, such as Hydantoins (phenytoin), Dihydropyridines, Diltiazem or Ciclosporin; * Medications that can cause gingival bleeding (anticoagulants, antiplatelet agents and aspirin); * Antibiotic therapy or professional scaling in the month prior to inclusion; * having used oral or topical antibiotics, antiseptics and/or antifungals (e.g., mouthwash, dental gels, etc.) in the month prior to inclusion. * Subjects with poor written and spoken French language skills; * previously included in the BUCCOTHERM study; * simultaneously participating in another trial that may interfere with the conduct of the BUCCOTHERM study or in a period of exclusion after participation in another clinical study; * protected persons (adults under legal protection (legal guardianship, curatorship, tutorship), persons deprived of liberty, pregnant or breastfeeding women, women of childbearing age without effective contraception (estrogen-progestin treatments, IUD, tubal ligation), minors.
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As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
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CHU Rennes
Rennes, France