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Could a simple mouthwash keep your Mouth's bacteria healthy?

NCT ID NCT04973358

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled This study
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study investigates whether a specific mouthwash (buccotherm) helps maintain a balanced and healthy community of bacteria in the mouth, compared to a placebo mouthwash. Healthy adults with at least 20 natural teeth will use the mouthwash twice daily for 14 weeks. Researchers will use advanced DNA sequencing to track changes in the types and diversity of oral bacteria, aiming to see if the mouthwash supports a healthy microbiome rather than disrupting it.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
buccotherm mouthwash
What this could lead to
If successful, this could show that certain mouthwashes support a healthy oral microbiome, potentially reducing risks of cavities, gum disease, and other health issues linked to oral bacteria.
What could go wrong
This is an early-stage study with a small number of participants. The mouthwash may not meaningfully change the microbiome compared to placebo, and any benefits for disease prevention remain speculative.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Expected to start

Jan 2022

An estimate. Start dates often move.

Expected to finish

Jan 2024

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 years and older

Sex

Anyone

Healthy volunteers

Accepted

You do not need to have the condition being studied to take part.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * 18 years of age or older: * with at least 20 permanent natural teeth, excluding crowns; * affiliated to a social security system; * having received information about the protocol and having given their free, informed and written consent. Exclusion Criteria: * with periodontitis in the month prior to inclusion; * with significant carious lesions deeply modifying the oral microbiota in the month prior to inclusion; * having undergone oral surgical treatment within 3 months prior to inclusion; * wearing orthodontic appliances; * having undergone periodontal procedures in the month prior to inclusion; * suffering from severe chronic pathologies deemed incompatible with study entry; * allergic to one of the swab components; * allergic to any of the components of the BUCCOTHERM mouthwash or the placebo; * on drugs that may cause gingival hypertrophy, such as Hydantoins (phenytoin), Dihydropyridines, Diltiazem or Ciclosporin; * Medications that can cause gingival bleeding (anticoagulants, antiplatelet agents and aspirin); * Antibiotic therapy or professional scaling in the month prior to inclusion; * having used oral or topical antibiotics, antiseptics and/or antifungals (e.g., mouthwash, dental gels, etc.) in the month prior to inclusion. * Subjects with poor written and spoken French language skills; * previously included in the BUCCOTHERM study; * simultaneously participating in another trial that may interfere with the conduct of the BUCCOTHERM study or in a period of exclusion after participation in another clinical study; * protected persons (adults under legal protection (legal guardianship, curatorship, tutorship), persons deprived of liberty, pregnant or breastfeeding women, women of childbearing age without effective contraception (estrogen-progestin treatments, IUD, tubal ligation), minors.

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As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Contacts and locations

Locations

  • CHU Rennes

    Rennes, France