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Eye drops could replace reading glasses for presbyopia

NCT ID NCT04774237

Symptom relief Sponsor: Visus Therapeutics Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed This study
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This Phase 2 trial tested three different eye drop formulas—BRIMOCHOL, BRIMOCHOL F, and carbachol alone—to see if they could improve near vision in people with presbyopia (age-related difficulty seeing up close). The study enrolled 18 adults who received a single drop in each eye. Researchers measured how many people gained at least 15 letters on a near vision chart without losing distance vision. This is an early, small study to check safety and effectiveness.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
BRIMOCHOL (carbachol/brimonidine tartrate) eye drops
What this could lead to
If successful, this could lead to a non-surgical eye drop that temporarily improves near vision for people with presbyopia.
What could go wrong
This is a very small Phase 2 trial with only 18 people, so results may not apply to everyone. The effect is temporary and may not work for all types of presbyopia.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Phase 2

Tests whether the treatment actually works, and watches for side effects, in a larger group.

Participants

18 people

The number who actually took part.

Started

Mar 2021

Finished

Oct 2021

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

45 to 80 years

Sex

Anyone

Healthy volunteers

Accepted

You do not need to have the condition being studied to take part.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Male or female in good general health * Must have presbyopia Exclusion Criteria: * History of allergic reaction to the study drug or any of its components * Any disease or medical condition that, in the opinion of the Investigator, would prevent the subject from participating in the study or might confound study results

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Conditions

The condition(s) this trial relates to.

presbyopia

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Presbyopia

Contacts and locations

Locations

  • Eye Research Foundation

    Newport Beach, California, 92663, United States

  • Global Research Management, Inc.

    Glendale, California, 91204, United States

  • Total Eye Care, PA

    Memphis, Tennessee, 38119, United States

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