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Can a light box fix sleep problems in MS?

NCT ID NCT04054050

Symptom relief Sponsor: Johns Hopkins University Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed This study
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 25, 2026 · Last updated Jul 22, 2026 · Updated 4 times

Summary

This study tested whether bright light therapy could help people with multiple sclerosis who have trouble sleeping. 27 participants used a light box at home. The goal was to see if it was safe and if it improved sleep and daily function.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
bright light therapy via a light box
What this could lead to
If it works, this could offer a simple, drug-free way to improve sleep and quality of life for people with MS.
What could go wrong
This was a very small pilot study with only 27 participants, so results may not apply to everyone. It focused on safety and early signals, not proof of effectiveness.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

27 people

The number who actually took part.

Started

Feb 2021

Finished

Jan 2026

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 years and older

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Diagnosis of MS * Evidence of sleep disturbance * Stable on immunomodulatory MS therapy or no therapy for at least 6 months prior to study initiation * Stable on antidepressants for at least 3 months prior to study initiation and no evidence * Stable on fatigue medication for at least 3 months prior to study initiation * Willing and able to provide informed consent and follow study procedures. Exclusion Criteria: * Evidence of cognitive impairment * Low risk for sleep disordered breathing * Other comorbid ophthalmologic disorders (e.g. cataracts, glaucoma, blindness) * Traveled across two time zones within 90 days of study screening. * Not participating in shift work * MS relapse or history of acute optic neuritis within 30 days * No prior history of bipolar disorder * No evidence of current depression * Diagnosis of severe periodic limb movement disorder or severe restless legs syndrome

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Conditions

The condition(s) this trial relates to.

Fatigue insomnia multiple sclerosis Parasomnias

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Multiple sclerosis

Contacts and locations

Locations

  • Johns Hopkins School of Medicine

    Baltimore, Maryland, 21287, United States

More trials for these conditions

Other studies related to the condition(s) this trial covers.