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Gentler breathing support may help preemies avoid harsh ventilators

NCT ID NCT07307079

Disease control Sponsor: Muhammad Aamir Latif Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed This study
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study looked at 100 premature babies (26-36 weeks) with respiratory distress syndrome who didn't improve with standard nasal CPAP. Researchers compared a newer, non-invasive high-frequency ventilation method (nHFOV) with traditional mechanical ventilation. The goal was to see which method improved oxygen levels better and led to fewer complications like lung damage or infections.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
Non-Invasive High-Frequency Oscillatory Ventilation (nHFOV) and Conventional Mechanical Ventilation (CMV)
What this could lead to
If nHFOV works better, it could offer a gentler breathing support option for premature babies, potentially reducing lung injury and other complications.
What could go wrong
This is a small, completed study. Results may not apply to all hospitals or babies. Both methods have risks like infection or air leaks.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

100 people

The number who actually took part.

Started

Jun 2025

Finished

Nov 2025

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

1 day to 28 days

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Neonates of any gender * Gestational age between 26 and 36 weeks * Diagnosed with RDS. * Failed to respond to nCPAP treatment Exclusion Criteria: * Major congenital anomalies like congenital diaphragmatic hernia, dysmorphism and congenital heart diseases * Early onset sepsis at the time of enrollment

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Conditions

The condition(s) this trial relates to.

adult acute respiratory distress syndrome respiratory distress syndrome in premature infants

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Respiratory distress syndrome

Contacts and locations

Locations

  • Indus Hospital - Recep Tayyip Erdogan Campus, Muzaffargarh

    Muzaffargarh, Punjab Province, 32400, Pakistan

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