New breathing exercise aims to help ventilator patients get stronger faster
NCT ID NCT07256821
First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time
Summary
This study looks at how to best strengthen the diaphragm—the main breathing muscle—in patients who are on a ventilator and have a tracheostomy. Researchers will test four different levels of breathing resistance and ask patients how they feel during each one. The goal is to design a breathing exercise program that is both effective and not too distressing for patients.
What this could mean
Our plain-language read of the trial. This is informational only, not medical advice or a prediction.
- Active substance
- Inspiratory muscle training (breathing exercises at different resistance levels)
- What this could lead to
- If successful, this could lead to a better breathing exercise program that helps patients on ventilators recover faster and leave the hospital sooner.
- What could go wrong
- This is a small, early-stage study with only 40 participants, so results may not apply to everyone. The exercises may still be uncomfortable or not improve outcomes.
This is an AI summary of the original study and may miss details. Read our disclaimer.
Study facts
What this study's own registry entry says, in plain language.
- Participants
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About 40 people
The number the study aims to enrol. It can still change while the study runs.
- Started
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Nov 2025
- Expected to finish
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Jan 2027
An estimate. End dates often move.
- Lead sponsor
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Other sponsor
The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.
Who can take part
This study's own entry requirements. Only the study team can say for certain whether you qualify.
Who is studied
Difficult to wean, mechanically ventilated patients
- Ages
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18 years and older
- Sex
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Anyone
- Healthy volunteers
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Not accepted
This study is not open to healthy volunteers. The entry requirements below say who it is open to.
Show the full entry requirements Hide the full entry requirements
Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.
Inclusion Criteria: * Mechanically ventilated patients with a tracheostomy * Aged ≥ 18 years * Co-operative and able to participate in IMT. * Informed consent or surrogate approval Exclusion Criteria: * Facial or skull fracture, or a bleeding disorder which would prohibit oesophageal catheter placement. * Undrained pneumothorax/pneumomediastinum. * Delirium or deep sedation that impedes the patient's ability to participate in study procedures * Pregnancy * Unlikely to survive, or consultant assessment that the patient is not appropriate. * Wounds that prohibit EMG electrode placement.
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As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
How to take part
Only the study team decides who joins. These are the ways to reach them.
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The places running it
1 site. The list below names each one and where it is.
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The official record
ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.
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A doctor treating you
A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.
Contacts and locations
Locations
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Royal Brompton and Harefield Hospitals
RECRUITINGMarlow, SL7 3AS, United Kingdom