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A simple breath test could spot mesothelioma years earlier

NCT ID NCT04106973

Diagnosis Sponsor: Henry Ford Health System Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early This study
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Aug 10, 2026 · Last updated Aug 11, 2026 · Updated 1 time

Summary

This study explores whether chemicals in a person's breath, called volatile organic compounds, can serve as early warning signs of pleural mesothelioma in people who have been exposed to asbestos. Researchers will also check if a blood marker, SMRP, adds to the breath test's accuracy. The goal is to find a non-invasive way to catch this cancer at an earlier, more treatable stage.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
Breath and blood biomarker analysis (volatile organic compounds and SMRP)
What this could lead to
If successful, this could lead to a simple breath test for early detection of mesothelioma in people exposed to asbestos, potentially improving treatment outcomes.
What could go wrong
This is a small early-stage study, so the biomarkers may not prove accurate enough for widespread use. The results will need confirmation in larger trials.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Participants

12 people

The number who actually took part.

Started

Jun 2019

Finished

Jan 2022

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Who is studied

Individuals with histologically confirmed pleural mesothelioma, and individuals with an asbestos exposure and radiological evidence of bilateral pleural plaques or pleural thickening without evidence of mesothelioma. The majority of asbestos exposed participants with bilateral pleural thickening or pleural plaques and no mesothelioma will be active or retired members of the International Association of Heat and Frost Insulators and Allied Workers Union.

Ages

18 years and older

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria * Male or Female over 18 years of age * Clinical diagnosis of pleural mesothelioma or presence of pleural plaques on X-Ray * Documented exposure to asbestos * Must be able to provide breath sample * Must be able to provide relevant medical information Exclusion Criteria * Presence of malignancies other that mesothelioma within the past 6 months * Treatment for any malignancies other than mesothelioma within the past 6 months * Inability to provide past clinical information * Inability to perform breath collection procedure * Smoking or consuming alcohol within two hours of conducting breath collection procedure

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Conditions

The condition(s) this trial relates to.

Mesothelioma, Malignant pleural mesothelioma

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Asbestos exposure Pleural mesothelioma Pleural plaque

Contacts and locations

Locations

  • Consultants in Sleep and Pulmonary Medicine

    Farmington Hills, Michigan, 48336, United States

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