New pill combo could replace chemo for some breast cancer patients
NCT ID NCT04293393
First seen Nov 01, 2025 · Last updated Apr 29, 2026 · Updated 21 times
Summary
This study tests whether a combination of two pills (letrozole and abemaciclib) works better than standard chemotherapy for women with a common type of early breast cancer (HR-positive, HER2-negative) that is at high or intermediate risk. About 200 women will receive either chemo or the pill combo before surgery. The goal is to see which treatment leaves less cancer remaining in the breast or lymph nodes after surgery.
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Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Contacts and locations
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Locations
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Complejo Hospitalario Universitario A Coruña (CHUAC)
A Coruña, 15006, Spain
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Complejo Hospitalario Universitario de Santiago (CHUS)
Santiago de Compostela, A Coruña, 15706, Spain
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Complejo Hospitalario de Jaén
Jaén, 23007, Spain
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Consorcio Hospitalario Provincial de Castellón
Castellon, Castelló, 12002, Spain
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Fundación Instituto Valenciano de Oncología (FIVO)
Valencia, 46009, Spain
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Hospital Clínico San Carlos
Madrid, 28040, Spain
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Hospital Clínico Universitario Lozano Blesa
Zaragoza, 50009, Spain
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Hospital Clínico Universitario Virgen de la Victoria
Málaga, 29010, Spain
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Hospital Clínico Universitario de Valencia
Valencia, 46010, Spain
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Hospital General Universitario Gregorio Marañón
Madrid, 28007, Spain
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Hospital General Universitario Morales Meseguer
Murcia, 30008, Spain
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Hospital General Universitario de Alicante
Alicante, 03010, Spain
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Hospital Universitari i Politécnic La Fe
Valencia, 46026, Spain
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Hospital Universitario Donostia
San Sebastián, Donostia, 20014, Spain
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Hospital Universitario Marqués de Valdecilla
Santander, Cantabria, 39008, Spain
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Hospital Universitario Miguel Servet
Zaragoza, 50009, Spain
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Hospital Universitario Nuestra Señora de Candelaria
Santa Cruz de Tenerife, 38010, Spain
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Hospital Universitario Ramón y Cajal
Madrid, 28034, Spain
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Hospital Universitario Reina Sofía
Córdoba, 14004, Spain
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Hospital Universitario Reina Sofía
Valencia, 46026, Spain
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Hospital Universitario San Pedro de Alcántara
Cáceres, 10003, Spain
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Hospital Universitario Virgen del Rocío
Seville, 41013, Spain
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Hospital Universitario de Badajoz
Badajoz, 06080, Spain
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Hospital Universitario de Burgos
Burgos, 09006, Spain
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Hospital Virgen de la Salud
Toledo, 45004, Spain
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Hospital Álvaro Cunqueiro
Vigo, Pontevedra, 36312, Spain
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Institut Català d'Oncología (ICO) Girona
Girona, 17007, Spain
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Institut Català d'Oncología (ICO) L'Hospitalet
L'Hospitalet de Llobregat, Barcelona, 08908, Spain
Conditions
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