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New pill combo could replace chemo for some breast cancer patients

NCT ID NCT04293393

Ongoing Disease control Sponsor: Spanish Breast Cancer Research Group Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study tests whether a combination of two pills (letrozole and abemaciclib) works as well as standard chemotherapy before surgery in women with a common type of early breast cancer (HR-positive, HER2-negative) that is at high or intermediate risk of coming back. About 200 women will be randomly assigned to one of the two treatments. The main goal is to see how many patients have little or no cancer left in the breast or lymph nodes after treatment.

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Conditions

The condition(s) this trial relates to.

breast cancer breast neoplasm

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

EARLY BREAST CANCER

Contacts and locations

Locations

  • Complejo Hospitalario Universitario A Coruña (CHUAC)

    A Coruña, 15006, Spain

  • Complejo Hospitalario Universitario de Santiago (CHUS)

    Santiago de Compostela, A Coruña, 15706, Spain

  • Complejo Hospitalario de Jaén

    Jaén, 23007, Spain

  • Consorcio Hospitalario Provincial de Castellón

    Castellon, Castelló, 12002, Spain

  • Fundación Instituto Valenciano de Oncología (FIVO)

    Valencia, 46009, Spain

  • Hospital Clínico San Carlos

    Madrid, 28040, Spain

  • Hospital Clínico Universitario Lozano Blesa

    Zaragoza, 50009, Spain

  • Hospital Clínico Universitario Virgen de la Victoria

    Málaga, 29010, Spain

  • Hospital Clínico Universitario de Valencia

    Valencia, 46010, Spain

  • Hospital General Universitario Gregorio Marañón

    Madrid, 28007, Spain

  • Hospital General Universitario Morales Meseguer

    Murcia, 30008, Spain

  • Hospital General Universitario de Alicante

    Alicante, 03010, Spain

  • Hospital Universitari i Politécnic La Fe

    Valencia, 46026, Spain

  • Hospital Universitario Donostia

    San Sebastián, Donostia, 20014, Spain

  • Hospital Universitario Marqués de Valdecilla

    Santander, Cantabria, 39008, Spain

  • Hospital Universitario Miguel Servet

    Zaragoza, 50009, Spain

  • Hospital Universitario Nuestra Señora de Candelaria

    Santa Cruz de Tenerife, 38010, Spain

  • Hospital Universitario Ramón y Cajal

    Madrid, 28034, Spain

  • Hospital Universitario Reina Sofía

    Córdoba, 14004, Spain

  • Hospital Universitario Reina Sofía

    Valencia, 46026, Spain

  • Hospital Universitario San Pedro de Alcántara

    Cáceres, 10003, Spain

  • Hospital Universitario Virgen del Rocío

    Seville, 41013, Spain

  • Hospital Universitario de Badajoz

    Badajoz, 06080, Spain

  • Hospital Universitario de Burgos

    Burgos, 09006, Spain

  • Hospital Virgen de la Salud

    Toledo, 45004, Spain

  • Hospital Álvaro Cunqueiro

    Vigo, Pontevedra, 36312, Spain

  • Institut Català d'Oncología (ICO) Girona

    Girona, 17007, Spain

  • Institut Català d'Oncología (ICO) L'Hospitalet

    L'Hospitalet de Llobregat, Barcelona, 08908, Spain

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