Brain scans reveal why stress triggers binge eating

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: Healthy Controls * Age 18-55 years old * Healthy body weight between 90 and 110 % average body weight since puberty. * Regular monthly menstrual cycle (if applicable) * Edinburgh Handedness Inventory Revised (EHI-R) LQ\* score \> +200 Obese * Age 18-55 years old * Current body mass index (BMI) \> 30 kg/m2. * Stable food intake regimen in previous 4 weeks. * Edinburgh Handedness Inventory Revised (EHI-R) LQ\* score \> +200 * Obese for at least one year Binge Eating Disorder * Age 18-55 years old * Edinburgh Handedness Inventory Revised (EHI-R) LQ\* score \> +200 * DSM 5 diagnosis of Binge Eating Disorder A. Recurrent episodes of binge eating B. Binge eating episodes are associated with three (or more) of the following 1. Eating much more rapidly than normal. 2. Eating until feeling uncomfortably full. 3. Eating large amounts of food when not feeling physically hungry. 4. Eating alone because of embarrassment. 5. Feeling disgusted with oneself, depressed, or very guilty after overeating. C. Marked distress regarding binge eating is present. D. At least once a week for 3 months. E. The binge eating is not associated with the recurrent use of inappropriate compensatory behavior. Bulimia Nervosa * Age 18-55 years old * Edinburgh Handedness Inventory Revised (EHI-R) LQ\* score \> +200 * DSM 5 diagnosis of Bulimia Nervosa A. Recurrent episodes of binge eating Eating, in a discrete period of time, an amount of food that is definitely larger than most people would eat during a similar period of time and under similar circumstances. A sense of lack of control over eating during the episode. B. Recurrent inappropriate compensatory behavior in order to prevent weight gain, such as self-induced vomiting; misuse of laxatives, diuretics, or other medications; fasting; or excessive exercise. C. At least once a week for 3 months. D. Self-evaluation is unduly influenced by body shape and weight. Exclusion Criteria: Healthy Controls * Current pregnancy or breast feeding within last 3 months * First degree relative with current or past eating disorder * Current Medications other than BCP or IUD * Past or present Axis I psychiatric disorder including substance or alcohol use disorder as determined through SCID-5 clinical interview * First degree relative with an eating disorder * Major Medical illness * Recent history of suspected substance abuse or a lifetime history of psychostimulant abuse and/or dependence * Metal implants or braces Obese * Current pregnancy or breast feeding within last 3 months * First degree relative with current or past eating disorder * Current or previous eating disorder diagnosis * Current Medications other than BCP or IUD * Past or present Axis I psychiatric disorder including substance or alcohol use disorder as determined through SCID-5 clinical interview * Major Medical illness * Recent history of suspected substance abuse or a lifetime history of psychostimulant abuse and/or dependence * Metal implants or braces Binge Eating Disorder * Pregnancy or breast feeding within last 3 months * Lifetime history of bipolar disorder or psychosis * Use of a psychostimulant within the prior 6 months * Recent history of substance abuse or dependence (except for alcohol and cannabis use) * Major Medical illness * Metal implants or braces Bulimia Nervosa * Pregnancy or breast feeding within last 3 months * Lifetime history of bipolar disorder or psychosis * Use of a psychostimulant within the prior 6 months * Recent history of substance abuse or dependence (except for alcohol and cannabis use) * Major Medical illness * Metal implants or braces