Could magnetic and electrical brain zaps slow Alzheimer's?
NCT ID NCT07075770
First seen Jun 27, 2026 · Last updated Jun 27, 2026
Summary
This study tests a new, non-invasive brain stimulation technique that combines magnetic and electrical pulses to target brain networks involved in memory. Researchers will enroll 60 people with mild Alzheimer's to see if this approach can improve thinking and daily function. The goal is to find a safe way to slow down the disease and help people maintain their independence longer.
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Study facts
What this study's own registry entry says, in plain language.
- Phase
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Not a phased trial
Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.
- Participants
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About 60 people
The number the study aims to enrol. It can still change while the study runs.
- Started
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Jan 2025
- Expected to finish
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Aug 2027
An estimate. End dates often move.
- Lead sponsor
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Other sponsor
The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.
Who can take part
This study's own entry requirements. Only the study team can say for certain whether you qualify.
- Ages
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50 to 85 years
- Sex
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Anyone
- Healthy volunteers
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Not accepted
This study is not open to healthy volunteers. The entry requirements below say who it is open to.
Show the full entry requirements Hide the full entry requirements
Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.
Inclusion Criteria: * Patients with a diagnosis of AD according to IWG criteria * 20 \> MMSE \< 28 * Patients with CSF specific biomarker profile or with a positive Amyloid Pet Scan consistent with the presence of amyloid pathology * Global Clinical Dementia Rating (CDR) ≤1 * Previous decline in cognition for more than six months as documented in patient medical records * A caregiver available and living in the same household or interacting with the patient and available * Patients living at home or nursing home setting without continuous nursing care * General health status acceptable for a participation in a 6-month clinical trial * Stable pharmacological treatment for at least one month prior to screening * No regular intake of prohibited medications. * Signed informed consent by the patient. If there are any doubts that the patient is mentally capable of giving informed consent, the patient will be examined and verified to be mentally capable by an independent physician/ neurologist, prior to the initiation of any study specific procedure. Signed consent of the caregiver Exclusion Criteria: * Failure to undergo screening or baseline exams * Hospitalization or change in chronic concomitant medications one month before the screening or during the screening period * Clinical, laboratory, or neuroimaging results consistent with: 1. other primary degenerative dementia (Lewy body dementia, frontotemporal dementia, Huntington's disease, Creutzfeldt-Jakob disease, Down syndrome, etc.); 2. other neurodegenerative conditions (Parkinson's disease, amyotrophic lateral sclerosis, etc.); 3. orthostatic hypotension and autonomic disorders 4. cerebrovascular disease (major infarction, a strategic infarction or multiple lacunar infarctions, extensive white matter lesions \> one quarter of total white matter); 5. other central nervous system diseases (severe traumatic brain injury, tumors, subdural hematoma, or other space-occupying processes, etc.); 6. seizure disorder. 7. Other infectious, metabolic, or systemic diseases affecting the central nervous system (syphilis, existing hypothyroidism, current vitamin B12 or folate deficiency, serum electrolytes outside normal limits, juvenile diabetes, etc.). * A current DSM-V diagnosis of major depression, schizophrenia, or bipolar disorder. * Clinically significant, advanced, or unstable disease that may interfere with primary or secondary variable assessments and may affect the assessment of the patient's clinical or mental state, or expose the patient to special risk, such as: 1. Disability that may prevent the patient from completing all study requirements (e.g., blindness, deafness, severe language difficulties, etc.); 2. Opioid-containing analgesics 3. Suspected or known drug or alcohol abuse, i.e., more than about 60 g of alcohol (about 1 liter of beer or 500 ml of wine) per day, indicated by a high mean corpuscular volume (MCV) above the normal value at screening; 4. Any condition that, in the investigator's judgment, makes the patient unsuitable for inclusion
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
How to take part
Only the study team decides who joins. These are the ways to reach them.
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The places running it
2 sites. The list below names each one and where it is.
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The official record
ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.
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A doctor treating you
A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.
Contacts and locations
Locations
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I.R.C.C.S. Centro Neurolesi Bonino Pulejo
NOT_YET_RECRUITINGMessina, Sicily, 98124, Italy
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IRCCS Santa Lucia Foundation
RECRUITINGRome, Italy, 00179, Italy
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