Scientists probe brain activity to map new depression treatments
NCT ID NCT05239780
First seen Nov 01, 2025 · Last updated Jun 23, 2026 · Updated 31 times
Summary
This study aims to understand how the brain processes rewards in people with depression. Researchers will record brain activity from epilepsy patients who also have depression while they play a gambling task. The goal is to identify abnormal brain signals that could guide future electrical stimulation treatments for depression.
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This is a summary of
the original study
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Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Contacts and locations
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Study contacts
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Contact
Phone: •••-•••-•••• Email: •••••@•••••
Locations
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Icahn School of Medicine at Mount Sinai
RECRUITINGNew York, New York, 100119, United States
Contact
Contact Phone: •••-•••-•••• Email: •••••@•••••
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
electrical brain stimulation
What this could lead to
If successful, this could identify new brain targets for stimulation to treat depression.
What could go wrong
This is a very small, early study in epilepsy patients, not a treatment trial. It may not lead to a working therapy for depression.
Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.