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Cardiac arrest survivors' brain function tracked for two years

NCT ID NCT03543371

Knowledge-focused Sponsor: Region Skane Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed This study
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study looks at how cardiac arrest affects thinking, memory, emotions, and sleep over time. About 200 survivors will take detailed brain tests 7 and 24 months after their cardiac arrest. Their results will be compared to heart attack patients who did not have a cardiac arrest, to understand what problems are unique to cardiac arrest.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

What this could lead to
If this study succeeds, it could help doctors better predict and support cognitive recovery after cardiac arrest.
What could go wrong
This is an observational sub-study, not a treatment trial. It cannot prove what causes cognitive changes, and results may not apply to all cardiac arrest survivors.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Participants

200 people

The number who actually took part.

Started

Jul 2018

Finished

May 2022

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Who is studied

OHCA survivors at TTM2-sites participating in this study. Survivors are invited to partake in this study at the regular six-month follow-up of the TTM2-trial. The cohort of MI patients acting as controls are recruited and assessed at one participating site per country through quality registers.

Ages

18 to 80 years

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * OHCA of a presumed cardiac or unknown cause (OHCA cohort only) * Sustained return of spontaneous circulation (ROSC) during intensive care - defined as 20 minutes with signs of circulation without the need for chest compressions (OHCA cohort only) * Unconsciousness - defined as not being able to obey verbal commands (FOUR-score motor response of \<4) and no verbal response to pain after sustained ROSC (OHCA cohort only) * Inclusion within 180 minutes of ROSC (OHCA cohort only) * During intensive care - eligible for intensive care without restrictions or limitations (OHCA cohort only) * MI with performed coronary angiography (MI cohort only) Exclusion Criteria: * Temperature on admission \<30°C (OHCA cohort only) * On extracorporeal membrane oxygenation (ECMO) prior to return of spontaneous circulation (OHCA cohort only) * Obvious or suspected pregnancy * Intracranial bleeding (OHCA cohort only) * Severe chronic obstructive pulmonary disorder (COPD) with long-term home oxygen therapy * Clinical dementia diagnosis before the event * Inability to speak the local language well enough to complete the assessment without assistance from an interpreter * Inability to meet for a face-to-face examination * Clinical Frailty Scale Index ≥8, indicating very severe frailty * Cardiac arrest before or in connection with MI (MI cohort only) * Active substance abuse

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Conditions

The condition(s) this trial relates to.

brain hypoxia - ischemia cardiac arrest Cognition Disorders cognitive disorder Fatigue insomnia myocardial infarction Out-of-Hospital Cardiac Arrest

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Cognition disorders Fatigue Heart arrest, out-of-hospital Hypoxia-ischemia, brain Insomnia Psychological distress

Contacts and locations

Locations

  • Aarhus University Hospital

    Aarhus, Denmark

  • Halmstad County Hospital

    Halmstad, Sweden

  • Helsingborg Hospital

    Helsingborg, Sweden

  • Sahlgrenska University Hospital

    Gothenburg, Sweden

  • Skane University Hospital

    Lund, Sweden

  • Skane University Hospital

    Malmö, Sweden

  • The Essex Cardiothoracic Centre, Basildon and Thurrock University Hospitals NHS Foundation Trust

    Basildon, Essex, United Kingdom

  • University Hospital of Wales, Cardiff and Vale University Health Board

    Cardiff, Wales, United Kingdom

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