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Nasal insulin spray reveals Brain's role in sugar control

NCT ID NCT06295640

Knowledge-focused Sponsor: University of Ulm Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing This study
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study looks at how insulin in the brain influences the body's handling of sugar after a meal. About 31 healthy volunteers will drink a sugary solution and receive either insulin or a placebo via nasal spray. Researchers will measure how the body produces and uses sugar to understand the brain's role in metabolism and any differences between men and women.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
intranasal insulin spray
What this could lead to
If successful, this could reveal how the brain helps regulate blood sugar after eating, potentially guiding future treatments for metabolic disorders.
What could go wrong
This is a small, early-stage study in healthy people, so results may not apply to those with diabetes or other conditions. The intervention is short-term and not intended as a treatment.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

31 people

The number who actually took part.

Started

Mar 2024

Expected to finish

Jun 2026

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 to 30 years

Sex

Anyone

Healthy volunteers

Accepted

You do not need to have the condition being studied to take part.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * BMI \< 24 kg/m2 * no known primary diseases * no hormonal contraception Exclusion Criteria: * Alcohol or drug abuse * Smoking * At screening: Hb \< 12 g/dl for women and Hb \< 14 g/dl for men * Any (clinical) condition that would endanger participant's safety or question scientific success according to a physician's opinion.

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Conditions

The condition(s) this trial relates to.

glucose metabolism disease Insulin Resistance

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Glucose metabolism disorders

Contacts and locations

Locations

  • Universityhospital Ulm

    Ulm, 89081, Germany

More trials for these conditions

Other studies related to the condition(s) this trial covers.