Breathing carbon dioxide reveals hidden brain risks in kids with sickle cell
NCT ID NCT04406818
First seen Oct 31, 2025 · Last updated Jun 19, 2026 · Updated 42 times
Summary
This study aims to understand how changes in blood flow and metabolism affect brain development in children with sickle cell anemia. Researchers will use MRI scans and have participants breathe carbon dioxide to test how well brain blood vessels expand. The study includes 120 children aged 4-21 with sickle cell disease and healthy controls, and will also assess cognitive function and brain structure.
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Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Contacts and locations
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Study contacts
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Contact
Phone: •••-•••-•••• Email: •••••@•••••
Locations
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Washington University in St. Louis
RECRUITINGSt Louis, Missouri, 63110, United States
Contact Phone: •••-•••-•••• Email: •••••@•••••
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
Carbon dioxide
What this could lead to
If successful, this could help doctors understand why some children with sickle cell disease develop brain damage, potentially leading to earlier detection or prevention strategies.
What could go wrong
This is an observational study, not a treatment trial. It is small (120 participants) and early-stage, so results may not apply to all patients. The carbon dioxide inhalation may cause temporary discomfort.
Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.