Den här översättningen är inte klar ännu. Den här sidan är just nu på engelska.

Gå till den engelska sidan

Cure My Disease

Don't miss your cure!

 Log in / Sign up

Brain activity may reveal who responds best to CBT for depression and anxiety

NCT ID NCT03175068

Knowledge-focused Sponsor: University of Illinois at Chicago Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed This study
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 24, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study looked at whether brain activity patterns can predict how well people with major depression or social anxiety respond to cognitive behavioral therapy (CBT). Over 200 participants were randomly assigned to 12 weeks of CBT or supportive therapy. Researchers measured brain activity during emotion regulation tasks before and after treatment. The goal was to understand how CBT works in the brain and for whom it is most effective.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
cognitive behavioral therapy (CBT)
What this could lead to
If successful, this could help doctors identify which patients are most likely to benefit from CBT, making treatment more personalized and effective.
What could go wrong
This is a completed study focused on understanding brain markers, not a new treatment. Results may not lead to immediate changes in care.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

203 people

The number who actually took part.

Started

Jul 2017

Finished

Mar 2022

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 to 65 years

Sex

Anyone

Healthy volunteers

Accepted

You do not need to have the condition being studied to take part.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: 1. generally medically and neurologically healthy, including no evidence of mental retardation or serious cognitive impairment that would interfere with protocol adherence and/or task performance 2. between the ages of 18 - 65 years old, inclusive 3. right-handed 4. primary diagnosis of MDD or gSAD based on the SCID DSM-5. Patients will be permitted to have limited comorbid and/or history of internalizing psychopathologies (e.g., generalized anxiety disorder, specific phobia, adjustment disorder) Exclusion Criteria: 1. personal current or past manic/hypomanic episode or psychotic symptoms 2. active suicidal ideation as determined by the Columbia Suicide Severity Rating Scale (C-SSRS) 3. prior history of standard CBT (failure or success) 4. any current or recent (past 4 weeks) use of medication (prescription or non-prescription) with psychotropic effects 5. psychotherapy other than CBT or psychotropic medication use during the study 6. cognitive dysfunction (traumatic brain injury, mental retardation, dementia) 7. active moderate or severe alcohol and/or substance use disorders For healthy controls: history or current Axis I disorder. Additional exclusion criteria for all participants pertaining to the fMRI scan include: 1. presence of ferrous-containing metals within the body (e.g., aneurysm clips, shrapnel/retained particles) 2. inability to tolerate small, enclosed spaces without anxiety (e.g., claustrophobia)

Get updates

Get notified about this study

Sign up to get updates when this study changes or when new studies for Major depressive disorder are added.

Vår säkerhetsrekommendation!

Genom att skicka in godkänner du våra Användarvillkor

Conditions

The condition(s) this trial relates to.

major depressive disorder social phobia

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Major depressive disorder Social anxiety disorder

Contacts and locations

Locations

  • University of Illinois at Chicago

    Chicago, Illinois, 60608, United States

More trials for these conditions

Other studies related to the condition(s) this trial covers.