New combo pill targets two heart risks at once
NCT ID NCT06165250
First seen Jun 27, 2026 · Last updated Aug 20, 2026 · Updated 2 times
Summary
This Phase 3 trial tested whether taking two experimental drugs, BR1018B and BR1018C, together can safely lower both blood pressure and LDL cholesterol. The study involved 156 adults with essential hypertension and primary hypercholesterolemia. Participants were randomly assigned to different drug combinations to compare effectiveness over 8 weeks.
What this could mean
Our plain-language read of the trial. This is informational only, not medical advice or a prediction.
- Active substance
- BR1018B and BR1018C (drugs for blood pressure and cholesterol)
- What this could lead to
- If successful, this could offer a new combination treatment option for people with both high blood pressure and high cholesterol.
- What could go wrong
- This is a completed Phase 3 trial, but results are not yet published. It may not show a meaningful advantage over existing treatments, and individual responses can vary.
This is an AI summary of the original study and may miss details. Read our disclaimer.
Study facts
What this study's own registry entry says, in plain language.
- Phase
-
Phase 3
Large-scale testing in a bigger group. Usually the last step before a treatment can be approved.
- Participants
-
151 people
The number who actually took part.
- Started
-
Apr 2024
- Finished
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Nov 2025
- Lead sponsor
-
A company
The lead sponsor is a pharmaceutical, biotech, or medical-device company.
Who can take part
This study's own entry requirements. Only the study team can say for certain whether you qualify.
- Ages
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19 years and older
- Sex
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Anyone
- Healthy volunteers
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Not accepted
This study is not open to healthy volunteers. The entry requirements below say who it is open to.
Show the full entry requirements Hide the full entry requirements
Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.
\<Inclusion Criteria\> Screening Visit (V1) * Patients with essential hypertension and primary hypercholesterolemia * If patients are being treated with antihypertensive/antihyperlipidemic drugs at screening, they should be determined to be medically reasonable by investigator about discontinuing existing antihypertensive/antihyperlipidemic drugs during the clinical trial * Patients under the following criteria at screening: * Patients who meet a fasting triglyceride (TG) \< 400 mg/dL and LDL-C ≤ 250 mg/dL * Patients who meet the following criteria, depending on whether antihypertensive drugs were administered within the last 4 weeks 1. Naïve : 140 mmHg ≤ MSSBP \< 180 mmHg and MSDBP \< 110 mmHg 2. Use antihypertensive drugs : 130 mmHg ≤ MSSBP \< 180 mmHg and MSDBP \< 110 mmHg Baseline Visit (V2) * Patients who meet the following criteria of blood pressure measured in selected reference arm at baseline (According to the clinical situation of each subject, Follow the blood pressure standards(Refer to 2022 The Korean Society of Hypertension Guideline)) * 140 mmHg(or 130 mmHg) ≤ MSSBP \< 180 mmHg * MSDBP \< 110 mmHg * Patients who meet fasting serum lipid profile test levels (LDL-C and TG) correspond to cardiovascular risk and risk factors at baseline (Refer to 2022 Korean Guidelines for the Management of Dyslipidemia (the 5th edition)) \<Exclusion Criteria\> * Patients with a difference of SiSBP ≥ 20 mmHg and SiDBP ≥ 10 mmHg in blood pressure measured three times on both arms at screening(V1) * Patients with blood pressure results showing MSSBP ≥ 180 mmHg or MSDBP ≥ 110 mmHg at screening(V1, both arms) and baseline(V2, selected reference arm) * Patients with a history of secondary hypertension or suspected secondary hypertension; (e.g., coarctation of the aorta, hyperaldosteronism, renal artery stenosis, renal hypertension, pheochromocytoma, Cushing's syndrome and polycystic kidney disease, etc.) * Patients with a history of secondary hyperlipidemia or suspected hyperlipidemia; (e.g., Chronic renal failure, nephrotic syndrome, dysproteinemia, obstructive liver disease, Cushing's syndrome, hypothyroidism, etc.) * Patients with hyportensive shock * Patients with orthostatic hypotension accompanied by symptoms
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
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Keimyung University Dongsan Hospital
Daegu, South Korea
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Seoul National University Boramae Medical Center
Seoul, South Korea
More trials for these conditions
Other studies related to the condition(s) this trial covers.
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- A simple arm cuff may lower blood pressure without drugs