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Gut cleanse may cloud thinking after surgery

NCT ID NCT05942404

Knowledge-focused Sponsor: TC Erciyes University Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed This study
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study looked at whether bowel cleansing before colorectal surgery is linked to memory or thinking problems after the operation. Researchers measured certain brain-related proteins in the blood and gave thinking tests to 84 patients before and after surgery. The goal was to understand how disrupting the gut's natural balance might affect the brain.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

84 people

The number who actually took part.

Started

Oct 2023

Finished

Jul 2024

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

45 to 80 years

Sex

Male participants only

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Patients who agreed to participate in the study * Patients undergoing elective colorectal surgery * Patients who can read and write * Patients whose hearing and sight are suitable for communication * Patients whose general sociocultural status is sufficient to perform psychometric tests. Exclusion Criteria: * Patients with inflammatory bowel * Patients with cerebrovascular disease * Patients who require emergency surgery * Patients who have had repetitive surgeries * Patients with neurodegenerative disease * Patients with severe and moderate dementia (MoCA test score 21 and below) * Patients with a mini mental test below 24 * Patients with severe hearing and vision impairment * Patients using antibiotics and probiotics * Patients who take long-term steroid therapy (7 days or more) * Patients receiving immunosuppressive therapy

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Conditions

The condition(s) this trial relates to.

frontotemporal dementia Postoperative Cognitive Complications

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Mechanical bowel preparation Pocd - postoperative cognitive dysfunction

Contacts and locations

Locations

  • Erciyes University

    Melikgazi, Kayseri, Turkey (Türkiye)

More trials for these conditions

Other studies related to the condition(s) this trial covers.