Could an extra injection boost botox for jaw pain?
NCT ID NCT07774884
First seen Aug 19, 2026 · Last updated Aug 20, 2026 · Updated 1 time
Summary
This trial tests whether adding an injection into the medial pterygoid muscle—a deep jaw-closing muscle often missed—improves pain relief when combined with standard botulinum toxin type A (Botox) injections into the masseter and temporalis muscles. The study includes 111 people with masticatory myofascial pain syndrome, a condition causing jaw muscle pain and impaired function. Participants receive either standard Botox treatment, a placebo, or standard treatment plus the medial pterygoid injection. The main goal is to see if the added injection reduces pain intensity more effectively.
What this could mean
Our plain-language read of the trial. This is informational only, not medical advice or a prediction.
- Active substance
- botulinum toxin type A (BoNT-A) injection
- What this could lead to
- If adding the medial pterygoid injection improves pain relief, it could lead to a more effective treatment protocol for people with jaw muscle pain.
- What could go wrong
- This is a small, early-stage trial, and the added injection may not provide extra benefit. There are also risks of injection-related side effects, such as temporary muscle weakness or pain.
This is an AI summary of the original study and may miss details. Read our disclaimer.
Study facts
What this study's own registry entry says, in plain language.
- Phase
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Not a phased trial
Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.
- Participants
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About 111 people
The number the study aims to enrol. It can still change while the study runs.
- Expected to start
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Sep 2026
An estimate. Start dates often move.
- Expected to finish
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May 2027
An estimate. End dates often move.
- Lead sponsor
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Other sponsor
The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.
Who can take part
This study's own entry requirements. Only the study team can say for certain whether you qualify.
- Ages
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18 years and older
- Sex
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Anyone
- Healthy volunteers
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Not accepted
This study is not open to healthy volunteers. The entry requirements below say who it is open to.
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Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.
Inclusion Criteria: * Diagnosis of myogenous TMD/myalgia according to DC/TMD. * Pain modified by jaw movement, function, or parafunction. * Familiar pain reproduced during standardized masseter/temporalis examination. * Clinical evidence of medial pterygoid involvement. * Medial pterygoid provocation reproduces the patient's familiar pain. * Symptoms present for at least 3 months. * No major competing odontogenic cause for the patient's pain. Exclusion Criteria: * Predominantly arthrogenous TMD. * Trigeminal neuralgia or other neuropathic facial pain. * Active systemic inflammatory or infectious disease affecting the masticatory muscles. * Significant neuromuscular disease. * Pregnancy or breastfeeding. * Previous BoNT-A injection into the relevant masticatory muscles during the predefined washout period. * Known hypersensitivity to the study medication or formulation components. * Local infection at the injection site. * Significant bleeding disorder. * Clinically significant uncontrolled anticoagulation. * Previous major surgery involving the medial pterygoid region that could alter anatomy.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
How to take part
Only the study team decides who joins. These are the ways to reach them.
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The places running it
1 site. The list below names each one and where it is.
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The official record
ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.
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A doctor treating you
A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.
Contacts and locations
Locations
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MUST University
Cairo, Cairo Governorate, 21523, Egypt
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