Den här översättningen är inte klar ännu. Den här sidan är just nu på engelska.

Gå till den engelska sidan

Cure My Disease

Don't miss your cure!

 Log in / Sign up

Botox-Like shots may calm shaky hands in essential tremor

NCT ID NCT04766723

Symptom relief Sponsor: Merz Pharmaceuticals GmbH Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed This study
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study tested whether a single injection of botulinum toxin (NT 201) can reduce hand tremors in people with essential tremor. 78 participants received either the drug or a placebo, and neither they nor the researchers knew who got what. The main goal was to measure tremor improvement using a wearable sensor and a clinical rating scale.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
Botulinum toxin (NT 201, also known as incobotulinumtoxinA or Xeomin)
What this could lead to
If it works, this could provide a new treatment option to reduce hand tremors in people with essential tremor.
What could go wrong
This is an early phase 2 trial with only 78 participants. The treatment may not work better than placebo, and botulinum toxin can cause muscle weakness or other side effects.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Phase 2

Tests whether the treatment actually works, and watches for side effects, in a larger group.

Participants

78 people

The number who actually took part.

Started

Feb 2021

Finished

Nov 2023

Lead sponsor

A company

The lead sponsor is a pharmaceutical, biotech, or medical-device company.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 years and older

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: \- Score of ≥ 2 (at least 1 cm tremor amplitude) in at least two out of three maneuvers of test item 4 (upper limb tremor) of the TETRAS performances scale confirmed by an independent TETRAS expert by means of video assessment. Exclusion Criteria: * History or presence of day-to-day fluctuations in ET which would jeopardize meaningful tremor assessment over time, e.g. severe tremor on one day and minimal or no tremor on another day. * Other neurological signs, such as dystonia, ataxia, or parkinsonism, which in the judgment of the investigator could interfere with the ET diagnosis and/or assessment of ET in ULs. * Tremor types other than ET

Get updates

Get notified about this study

Sign up to get updates when this study changes or when new studies for Essential tremor of the upper limb are added.

Vår säkerhetsrekommendation!

Genom att skicka in godkänner du våra Användarvillkor

Conditions

The condition(s) this trial relates to.

essential tremor

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Essential tremor of the upper limb

Contacts and locations

Locations

  • Cleveland Clinic Lou Ruvo Center for Brain Health, Merz Investigational Site #0010457

    Las Vegas, Nevada, 89106, United States

  • Houston Methodist Neurological Institute, Merz Investigational Site #0010226

    Houston, Texas, 77030, United States

  • Instytut Zdrowia Dr. Boczarska-Jedynak

    Oświęcim, 32-600, Poland

  • London Health Sciences Centre, Merz Investigational Site #0010087

    London, Ontario, N6A 5A5, Canada

  • Mazowiecki Szpital Bródnowski, Merz Investigational Site #0480064

    Warsaw, 03-242, Poland

  • Medstar Georgetown Neurology, Merz Investigational Site #0010231

    McLean, Virginia, 22101, United States

  • Mount Sinai Medical Center, Merz Investigational Site #0010191

    New York, New York, 10029, United States

  • NeuroKlinika Gabinet Lekarski, Merz Investigational Site #0480101

    Lodz, 90-640, Poland

  • Selkirk Neurology, Merz Investigational Site #0010456

    Spokane, Washington, 99202, United States

  • Specjalistyczne Gabinety, Merz Investigational Site #0480059

    Krakow, 30-539, Poland

  • USF, Department of Neurology, Merz Investigational Site #0010020

    Tampa, Florida, 33612, United States

  • UW Medical Center - Montlake, Merz Investigational Site #0010450

    Seattle, Washington, 98195, United States

  • University of Nebraska Medical Center, Merz Investigational Site #0010269

    Omaha, Nebraska, 68131, United States

  • Vanderbilt University Medical Center, Neuroscience Institute, Merz Investigational Site #0010206

    Nashville, Tennessee, 37232, United States