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Botox vs. scalpel: which heals anal fissures better?

NCT ID NCT07568314

Symptom relief Sponsor: Islamabad Medical and Dental College Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed This study
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 26, 2026 · Last updated Aug 14, 2026 · Updated 3 times

Summary

This study compares two treatments for chronic anal fissure, a painful condition. One group gets Botox injections to relax the muscle; the other has a minor surgery called lateral internal sphincterotomy. Researchers will track healing, pain, and side effects in 90 adults over 3 months to see which option works best.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
Botulinum toxin type A (Botox) injection
What this could lead to
If this trial shows Botox works as well as surgery, patients may have a less invasive option for chronic anal fissure relief.
What could go wrong
This is a small, single-center study. Botox effects are temporary, and surgery carries risks like incontinence. Results may not apply to all patients.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

90 people

The number who actually took part.

Started

Mar 2026

Finished

Jun 2026

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 to 65 years

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Age 18-65 years * Diagnosed chronic anal fissure (\>6 weeks duration) * Failure of conservative management * Both male and female patients * Willingness to provide informed consent Exclusion Criteria: * Acute anal fissure * Previous anal surgery * Inflammatory bowel disease * Pregnancy * Neurological disorders affecting continence * Known hypersensitivity to botulinum toxin

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As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Anal fissure chronic

Contacts and locations

Locations

  • Islamabad Medical and Dental College

    Islamabad, Federal, 44000, Pakistan

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