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Botox or aromatherapy? new study pits two treatments against sleep grinding

NCT ID NCT06674733

Symptom relief Sponsor: Bezmialem Vakif University Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed This study
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 26, 2026 · Last updated Jun 26, 2026

Summary

This study compared two treatments for sleep bruxism (teeth grinding): botox injections and marjoram oil aromatherapy. Thirty adults with sleep bruxism were split into two groups, receiving either botox or marjoram oil. Researchers measured changes in jaw muscle thickness, pain, and sleep quality over three months to see which approach worked better.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
botulinum toxin-A (Botox) and marjoram oil
What this could lead to
If successful, this could point toward a non-surgical treatment option for sleep bruxism, potentially easing jaw pain and improving sleep quality.
What could go wrong
This is a small, early study with only 30 participants, so results may not apply to everyone. Botox injections carry risks like muscle weakness, and marjoram oil's effectiveness is not well proven.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

30 people

The number who actually took part.

Started

Oct 2024

Finished

Mar 2025

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 to 60 years

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: 1. Self-reported teeth clenching or grinding 2. Tenderness or fatigue in the masticatory muscles upon palpation 3. Increased morning muscle pain 4. Localized myofascial pain in the jaw, face, or neck region 5. Irregular or excessive enamel wear consistent with bruxism 6. Grinding sounds during sleep confirmed by a partner 7. Morning jaw muscle stiffness and spasms causing sleep disturbances 8. Individuals older than 18 years, 9. Individuals younger than 60 years, 10. Provided informed voluntary consent Exclusion Criteria: 1. Botulinum toxin injection into the masseter muscle within the last 6 months 2. Use of night guards 3. Pathology or history of surgery involving the masseter muscle or parotid gland 4. Benign or malignant tumors in the mandibular region 5. History of alcohol or substance abuse 6. Age below 18 or above 60 7. Pregnancy, postpartum period, or breastfeeding 8. Infection or dermatological lesions at the injection site 9. Diagnosis of chronic obstructive pulmonary disease (COPD) or asthma 10. Known allergy or skin reaction to botulinum toxin A or essential oils used in aromatherapy 11. Use of muscle relaxants or other medications that may affect muscle function

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Conditions

The condition(s) this trial relates to.

bruxism parasomnia, sleep bruxism type Sleep Bruxism

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Bruxism, sleep

Contacts and locations

Locations

  • Bezmialem Vakif University

    Istanbul, Fatih, 34093, Turkey (Türkiye)

More trials for these conditions

Other studies related to the condition(s) this trial covers.