Could faulty stem cells in the airways drive a rare lung disease? a study aims to find out.
NCT ID NCT07018804
First seen Jul 29, 2026 · Last updated Jul 30, 2026 · Updated 1 time
Summary
This study explores whether stem cell dysfunction in the small airways causes bronchiolitis obliterans syndrome (BOS), a serious lung condition that can occur after a stem cell transplant. Researchers will collect airway cells from people with BOS and healthy volunteers to compare how these cells behave. The goal is to uncover the root cause of BOS and identify potential targets for future treatments.
What this could mean
Our plain-language read of the trial. This is informational only, not medical advice or a prediction.
- Active substance
- bronchoscopic brushing, single-cell cloning, cell function identification
- What this could lead to
- If the link between stem cell dysfunction and BOS is confirmed, this could point toward targeted therapies that repair airway damage and improve outcomes.
- What could go wrong
- This is an early experimental study with lab and animal models, not a treatment trial. Findings may not translate to humans or lead to a therapy.
This is an AI summary of the original study and may miss details. Read our disclaimer.
Study facts
What this study's own registry entry says, in plain language.
- Phase
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Not a phased trial
Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.
- Expected to start
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Jul 2026
An estimate. Start dates often move.
- Expected to finish
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Jun 2028
An estimate. End dates often move.
- Lead sponsor
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Other sponsor
The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.
Who can take part
This study's own entry requirements. Only the study team can say for certain whether you qualify.
- Ages
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Children (under 18), adults (18 to 64) and older adults (65 and over)
- Sex
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Anyone
- Healthy volunteers
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Accepted
You do not need to have the condition being studied to take part.
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Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.
Inclusion Criteria: * Patients who have received allogeneic hematopoietic stem cell transplantation and are diagnosed with bronchiolitis obliterans syndrome Exclusion Criteria: * Bronchoscopy consultation is not suitable for patients who are not suitable for bronchoscopy.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
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Haikou Affiliated Hospital of Central South University Xiangya School of Medicine
Haikou, Hainan, 570208, China
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Other studies related to the condition(s) this trial covers.