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Do 3D-printed aligners change bone health differently than standard ones?

NCT ID NCT07617571

Knowledge-focused Sponsor: Alexandria University Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting This study
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study looks at how two types of clear aligners—3D-printed versus thermoformed—affect bone metabolism in adults with minor crowding. Thirty participants will be randomly assigned to one type, and researchers will measure changes in a bone-related protein and gum health. The goal is to see if the manufacturing method makes a difference in how the jawbone responds to tooth movement.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
Orthodontic aligners (3D-printed resin or thermoformed PETG)
What this could lead to
If successful, this could help orthodontists choose aligner materials that are gentler on bone, potentially improving treatment outcomes.
What could go wrong
This is a small, early-stage study (30 people) measuring bone markers, not clinical outcomes. Results may not translate to real-world benefits or apply to more complex cases.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

About 30 people

The number the study aims to enrol. It can still change while the study runs.

Expected to start

Jun 2026

An estimate. Start dates often move.

Expected to finish

Jul 2026

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 to 25 years

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Minor malocclusion (2 to 4 mm of crowding) . * Patients in need for Antero-posterior expansion and labial tipping of incisors without interproximal reduction * No use of anti-inflammatory drugs or antibiotics in the past 6 months. * Periodontal parameters of gingival index \<1 and no pocketing with a generalized pocketing depth of \<3mm. * Radiographic parameters of no crestal bone loss. * No history of smoking. Exclusion Criteria: * Signs of inflammation of the gingiva, and periodontitis. * Systemic conditions (kidney disease, HIV, and liver disease). * Teeth missing or poor oral hygiene. * Bone disease e.g.; osteoporosis.

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Conditions

The condition(s) this trial relates to.

malocclusion due to protuberant upper front teeth

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Bone metabolism Orthodontic aligners

How to take part

Only the study team decides who joins. These are the ways to reach them.

  1. The places running it

    1 site. The list below names each one and where it is.

  2. The official record

    ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.

    Open the record ↗

  3. A doctor treating you

    A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.

Contacts and locations

Locations

  • Faculty of Dentistry, Alexandria University

    Alexandria, Egypt

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