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Man-Made bone graft could replace donor tissue in dental implants

NCT ID NCT07020650

Disease control Sponsor: University of Michigan Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only This study
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 2 times

Summary

This study tests whether a synthetic bone graft material (carbonate apatite) helps preserve the jawbone after tooth extraction better than grafts from human or cow bone. Researchers will measure bone changes using scans and tissue samples. The study involves 45 adults needing a tooth removed who plan to get a dental implant later.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
carbonate apatite bone graft
What this could lead to
If successful, this could provide a synthetic alternative to natural bone grafts for preserving jawbone after tooth extraction, potentially improving outcomes for future dental implants.
What could go wrong
This is a small early-stage study (45 people) comparing different graft materials, so results may not apply to everyone. The synthetic graft may not perform better than existing options.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

About 45 people

The number the study aims to enrol. It can still change while the study runs.

Started

Jun 2025

Expected to finish

Jun 2027

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

20 to 80 years

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion criteria: * Age between 20 and 80 years old * Patients requiring tooth extraction (incisors, canines, and premolars) due to caries, periodontal disease, tooth fracture, or unrestorable condition. * Extraction sockets must be infection-free with dehiscence less than 5mm. * Patients interested in implant placement after tooth extraction. Exclusion criteria: * Known allergies or hypersensitivities to medications related to the study (e.g., chlorhexidine) * Hematologic disorders or blood dyscrasias. * Active infectious diseases. * Liver or kidney dysfunction/failure. * Uncontrolled diabetes (i.e., HbA1c \> 8). * Undergoing active cancer treatment, including chemotherapy or radiotherapy within the last 12 months from the procedure. * Use of medications affecting bone healing (e.g., bisphosphonates, long-term anti-inflammatory medications). * Metabolic bone diseases affecting bone healing, such as osteoporosis (self-reported). * Pregnant or lactating women (self-reported). * Current smokers of 10 or more cigarettes per day and former smokers who quit less than 10 years ago (self-reported). * Poor oral hygiene. * Presence of fenestration defects equal to or greater than 5mm.

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As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Healing wound

How to take part

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  1. The places running it

    1 site. The list below names each one and where it is.

  2. The official record

    The full official record for this study. This one lists no contact details, but it is the first place any would appear.

    Open the record ↗

  3. A doctor treating you

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Contacts and locations

Locations

  • University of Michigan School of Dentistry

    Ann Arbor, Michigan, 48109, United States

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