Two bone grafting techniques face off for rebuilding jawbone
NCT ID NCT07825896
First seen Sep 17, 2026 · Last updated Sep 18, 2026 · Updated 1 time
Summary
When people lose back teeth in the lower jaw, the bone ridge can shrink, making it hard to place dental implants. This trial compares two ways to rebuild that ridge: a patient's own bone mixed into a sticky paste with a platelet-rich fibrin membrane, versus a donor bone graft with a collagen membrane. Researchers will place implants at the same time and track how stable the implants are, how much bone width is gained, and how much bone is lost around the implants over several months. They will also record pain and swelling in the days after surgery.
What this could mean
Our plain-language read of the trial. This is informational only, not medical advice or a prediction.
- Active substance
- autogenous sticky bone with platelet-rich fibrin membrane versus xenograft with collagen membrane
- What this could lead to
- If one method proves better, it could guide dentists toward a more reliable way to rebuild jawbone before placing implants.
- What could go wrong
- This is a small, single-center study of 26 people, so results may not apply broadly. Bone grafting can fail to integrate, and individual healing varies.
This is an AI summary of the original study and may miss details. Read our disclaimer.
Study facts
What this study's own registry entry says, in plain language.
- Phase
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Not a phased trial
Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.
- Participants
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About 26 people
The number the study aims to enrol. It can still change while the study runs.
- Expected to start
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Sep 2026
An estimate. Start dates often move.
- Expected to finish
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Jun 2027
An estimate. End dates often move.
- Lead sponsor
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Other sponsor
The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.
Who can take part
This study's own entry requirements. Only the study team can say for certain whether you qualify.
- Ages
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20 to 60 years
- Sex
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Anyone
- Healthy volunteers
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Not accepted
This study is not open to healthy volunteers. The entry requirements below say who it is open to.
Show the full entry requirements Hide the full entry requirements
Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.
Inclusion Criteria: * Patients with missing posterior mandibular teeth. * Horizontal bone defect with width \< 5.5 mm. * Adequate zone of keratinized tissue Exclusion Criteria: * Presence of infection or periapical lesions in adjacent teeth. * Medically compromised patients with a condition that affects the procedure. * Insufficient inter-arch distance. * Bruxism or clenching. * Alcoholism. * Heavy Smokers.
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As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
How to take part
Only the study team decides who joins. These are the ways to reach them.
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The places running it
1 site. The list below names each one and where it is.
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The official record
ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.
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A doctor treating you
A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.
Contacts and locations
Locations
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Outpatient Clinic of Oral and Maxillofacial Surgery Department, Faculty of Dentistry, Alexandria University, Egypt
Alexandria, Azarita, 00203, Egypt
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