Knee surgery patients get bone marrow shot to halt arthritis
NCT ID NCT02582489
First seen Jun 27, 2026 · Last updated Jun 27, 2026
Summary
This study tests whether injecting a concentrated sample of a patient's own bone marrow into the knee right after meniscus surgery can slow down or prevent arthritis. One hundred adults with a torn meniscus will receive either the bone marrow injection or a saltwater placebo, and their knee function, pain, and imaging results will be tracked for a year. The goal is to see if this simple procedure can improve long-term outcomes after a common knee operation.
What this could mean
Our plain-language read of the trial. This is informational only, not medical advice or a prediction.
- Active substance
- Bone marrow aspirate concentrate (BMAC)
- What this could lead to
- If it works, this could point toward a way to slow or prevent osteoarthritis after knee surgery, potentially reducing pain and improving long-term knee function.
- What could go wrong
- This is a small, early-phase trial with only 100 participants. The treatment may not provide any benefit over a placebo, and the effects on osteoarthritis progression are uncertain.
This is an AI summary of the original study and may miss details. Read our disclaimer.
Study facts
What this study's own registry entry says, in plain language.
- Phase
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Not a phased trial
Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.
- Participants
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About 100 people
The number the study aims to enrol. It can still change while the study runs.
- Started
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Dec 2017
- Expected to finish
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Dec 2026
An estimate. End dates often move.
- Lead sponsor
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Other sponsor
The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.
Who can take part
This study's own entry requirements. Only the study team can say for certain whether you qualify.
- Ages
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18 years and older
- Sex
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Anyone
- Healthy volunteers
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Not accepted
This study is not open to healthy volunteers. The entry requirements below say who it is open to.
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Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.
Inclusion Criteria: * Subject is greater than 18 years old * Written informed consent is obtained * Subject is determined to have a symptomatic meniscal tear requiring a meniscectomy * Meniscal pathology is confirmed through MRI and arthroscopically * Subject agrees to all follow-up evaluations * Osteoarthritis Kellen-Lawrence grade 1-3 on flexion PA and extension AP views Exclusion Criteria: * Any subject lacking decisional capability * Unwillingness to participate in the necessary follow-up * Subject is pregnant or may become pregnant * History of diabetes mellitus * History of rheumatoid arthritis or other autoimmune disorder * History of solid organ or hematologic transplantation * Diagnosis of a non-basal cell malignancy within the preceding 5 years * Infection requiring antibiotic treatment within the preceding 3 months * Osteoarthritis Kellen-Lawrence grade 4 on flexion posterior-anterior (PA) or extension anteroposterior (AP) views * Prior surgery on the index meniscus * Concomitant surgery such as ligament surgery or cartilage repair or restoration * Infection * Prior cortisone/viscosupplementation/ (platelet rich plasma) PRP injection within 6 weeks
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
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Rush University Medical Center
Chicago, Illinois, 60612, United States