Brain monitor may guide safer blood pressure during surgery

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria (All patients): * undergoing major noncardiac surgery in general anesthesia will be included. Major noncardiac surgery is defined as: * vascular surgery (with the exception of arteriovenous shunt, vein stripping procedures and carotid endarterectomies) * intraperitoneal surgery * intrathoracic surgery * major orthopedic surgery * at cardiovascular risk, defined as meeting at least 1 of the following 6 criteria: * preoperative NT-proBNP ≥ 200 ng/l * history of coronary artery disease * history of peripheral vascular disease * history of stroke * undergoing major vascular surgery, with the exception of arteriovenous shunt, vein stripping procedures and carotid endarterectomies * fulfillment of any 3 of the 8 following criteria: * undergoing major surgery (intrathoracic, intraperitoneal or suprainguinal vascular surgery) * any history of CHF or history of pulmonary edema * anamnestic transient ischemic attack (TIA) * diabetes under treatment with either oral antidiabetic agent or insulin * age \> 70 years * history of hypertension * serum creatinine \> 175 mcmol/l or calculated creatinine clearance \< 60 l/min/1.73m2 (Cockroft Gault) * history of smoking within 2 years of surgery * intraoperative continuous invasive blood pressure monitoring indicated due to anesthetic or surgical factors * planned surgical time ≥ 90 minutes * planned postoperative hospital stay at least 1 night Additional inclusion criteria for neurologic injury sub-study: * Age ≥ 65 years Exclusion Criteria (All patients): * pregnancy (anamnestic) * emergent surgery * urological surgery * renal insufficiency with creatinine clearance \< 30 ml/min (Cockroft- Gault equation) or on dialysis * inclusion in an interventional clinical trial with any common endpoints: acute kidney injury, perioperative myocardial injury, components of the composite major cardiovascular, renal and neurological complications up to 1 year following surgery (ACS, CHF, coronary revascularization, stroke, new CKD or progression of CKD, new need for renal replacement therapy, mortality), neurological injury, delirium, exception: potential inclusion of subset of patients in RCT investigating the perioperative use of colchicine in major noncardiac surgery (COLCAT study). * previously enrolled in this study