Could a simple drug combo make C-Sections safer?
NCT ID NCT07379710
First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time
Summary
This study tests whether adding ephedrine to a standard norepinephrine drip can better prevent low blood pressure during C-sections done under spinal anesthesia. 260 women having planned C-sections will be randomly assigned to receive either the combo or norepinephrine alone. The goal is to see if the combo reduces blood pressure drops and keeps heart rate stable.
What this could mean
Our plain-language read of the trial. This is informational only, not medical advice or a prediction.
- Active substance
- ephedrine and norepinephrine
- What this could lead to
- If it works, this could offer a better way to prevent dangerous drops in blood pressure during C-sections, improving safety for mothers and babies.
- What could go wrong
- This is a small, early-phase trial testing a common drug combination. The results may not apply to all patients, and there are risks like high blood pressure or slow heart rate.
This is an AI summary of the original study and may miss details. Read our disclaimer.
Study facts
What this study's own registry entry says, in plain language.
- Phase
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Phase 4
Runs after approval, following long-term safety and how well the treatment works in everyday use.
- Participants
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About 260 people
The number the study aims to enrol. It can still change while the study runs.
- Expected to start
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Jun 2026
An estimate. Start dates often move.
- Expected to finish
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Feb 2027
An estimate. End dates often move.
- Lead sponsor
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Other sponsor
The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.
Who can take part
This study's own entry requirements. Only the study team can say for certain whether you qualify.
- Ages
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18 to 40 years
- Sex
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Female participants only
- Healthy volunteers
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Not accepted
This study is not open to healthy volunteers. The entry requirements below say who it is open to.
Show the full entry requirements Hide the full entry requirements
Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.
Inclusion Criteria: * ASA physical status II * Age: 18 to 40 years * Undergoing Elective Lower Segment Cesarean Section under Spinal Anesthesia. Exclusion Criteria: * Uncontrolled cardiac morbidities As reduction of ejection fraction\< 60%, History (within 3months) of myocardial infarction, cerebrovascular accident, transient ischemic attacks or coronary artery disease/stents * Poorly controlled Hypertensive disorders of pregnancy * Peripartum bleeding * Coagulation disorders * Baseline systolic blood pressure (SBP) \< 100 mmHg * Refusal of patients.
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As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
How to take part
Only the study team decides who joins. These are the ways to reach them.
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The places running it
1 site. The list below names each one and where it is.
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The official record
ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.
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A doctor treating you
A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.
Contacts and locations
Locations
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Faculty of Medicine, Cairo University, Cairo
Cairo, 11562, Egypt