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Full-Body scan reveals how heart valve disease affects blood flow to organs

NCT ID NCT04941248

Knowledge-focused Sponsor: RenJi Hospital Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed This study
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 24, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This completed study from RenJi Hospital used a special full-body PET/CT scanner to measure blood flow throughout the body in 34 people: 9 healthy volunteers and 16 patients with severe aortic stenosis and reduced heart function. The goal was to see how blood flow differs between healthy people and patients, and how it changes after TAVR (a minimally invasive valve replacement). The study does not test a new drug or treatment, but aims to improve understanding of the disease.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

What this could lead to
If successful, this could help doctors understand how severe aortic stenosis affects blood flow to organs and how TAVR surgery may improve it.
What could go wrong
This is a small, early-stage imaging study with only 34 participants, so results may not apply to all patients. It does not test a treatment or directly improve health.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Participants

34 people

The number who actually took part.

Started

Jun 2021

Finished

Feb 2026

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Who is studied

Individuals aged between 60 and 90 years old with severe AS condition will be eligible for our enrollment; and participants without any history of vascular disease will be eligible.

Ages

60 to 90 years

Sex

Anyone

Healthy volunteers

Accepted

You do not need to have the condition being studied to take part.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Nine healthy volunteers with normal EF values * Patients with decreased cardiac function, while their heart function grading above II(New York Heart Association,NYHA) * Aged 60\~90 years old * Written informed consents will be offered and signed by all participants Exclusion Criteria: * History of vascular-related diseases in other organs * Severe liver and kidney dysfunctions * Patients who are pregnant or breast feeding * People under the age of 60 years old * Heart function grading below II(NYHA) * inability to lie or to maintain posture in the scanner for one hour

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Conditions

The condition(s) this trial relates to.

aortic valve stenosis

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Cardiac output

Contacts and locations

Locations

  • Shanghai jiaotong University School of Medicine, Renji Hospital

    Shanghai, Shanghai Municipality, 200127, China

More trials for these conditions

Other studies related to the condition(s) this trial covers.