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New hope for older leukemia patients: targeted drug combo shows promise

NCT ID NCT04994717

Disease control Sponsor: Amgen Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing This study
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 26, 2026 · Last updated Jul 01, 2026 · Updated 3 times

Summary

This Phase 3 trial is testing whether a targeted immunotherapy drug called blinatumomab, given alongside low-intensity chemotherapy, works better than standard chemotherapy for older adults (55+) with a specific type of acute lymphoblastic leukemia (ALL). The study involves 303 participants and aims to see if the new combination improves survival and reduces the chance of the cancer coming back. The trial is no longer recruiting, and results are awaited.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
Blinatumomab (Blincyto) and low-intensity chemotherapy
What this could lead to
If successful, this could offer a more effective and less toxic treatment option for older adults with a hard-to-treat leukemia, potentially improving survival and reducing relapse.
What could go wrong
This is a Phase 3 trial, but results are not yet available. The experimental combination may not prove better than standard chemo, and side effects like infections or neurological issues remain a concern.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Phase 3

Large-scale testing in a bigger group. Usually the last step before a treatment can be approved.

Participants

303 people

The number who actually took part.

Started

Nov 2021

Expected to finish

Jun 2031

An estimate. End dates often move.

Lead sponsor

A company

The lead sponsor is a pharmaceutical, biotech, or medical-device company.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

40 to 100 years

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: \- Age ≥ 55 years at the time of informed consent. OR Age 40 to \< 55 years of age if at least 1 of the following comorbidities at the time of informed consent: * history of grades 3 and 4 pancreatitis * diabetes mellitus with end-organ damage * severe liver disease such as cirrhosis stage 2 with portal hypertension or history of esophageal variceal bleeding and aspartate transaminase (AST)/alanine aminotransferase (ALT) \> 10 x upper limit of normal (ULN) (liver cirrhosis must be confirmed by biopsy) * body mass index (BMI) ≥ 40 combined with relevant comorbidities such as metabolic syndrome * Any further combination of documented severe comorbidities that the investigator judges to be incompatible with administering an intensive pediatric based, adult adapted standard chemotherapy regimen but still compatible with the suggested protocol for older participants in both the experimental and the SOC arm. The participant history will be reviewed by the medical monitor during screening to determine enrollment acceptability based on a standard list with types of comorbidities allowed. * Participants with newly diagnosed Philadelphia (Ph)-negative B-cell precursor acute lymphoblastic leukemia (ALL) * Eastern Cooperative Oncology Group (ECOG) performance status ≤ 2, higher ECOG score allowed if due to underlying leukemia * All participants must have adequate organ function as defined below: * renal: estimated glomerular filtration rate based on MDRD calculation ≥ 50 mL/min/1.73 m\^2 * liver function: total bilirubin ≤ 2x upper limit of normal (ULN; unless Gilbert's Disease or if liver involvement with leukemia); exception for participants 40 to \< 55 years of age if they have a comorbidity listed above: severe liver disease such as cirrhosis stage 2 with portal hypertension or history of esophageal variceal bleeding and AST/ALT \> 10 x ULN (liver cirrhosis must be confirmed by biopsy) * cardiac: left ventricular ejection fraction (LVEF) ≥ 50% and no clinically significant, uncontrolled, or active cardiovascular disease (eg, myocardial infarction or stroke within 3 months). Consult with medical monitor as needed. Exclusion Criteria: * Active central nervous system (CNS) leukemia (i.e., CNS 3 leukemia, confirmed by lumbar puncture) not resolved with IT chemotherapy during screening. * History of other malignancy within the past 3 years, with the following exceptions: * Malignancy treated with curative intent and with no known active disease present for ≥ 3 years before enrollment and felt to be at low risk for recurrence by the treating physician Note: History of other malignancy (eg, multiple myeloma) treated with immunomodulatory drugs (eg, lenalidomide, thalidomide) in the past 3 years is an exclusion. * Adequately treated non-melanoma skin cancer or lentigo maligna without evidence of disease * Adequately treated cervical carcinoma in situ without evidence of disease * Adequately treated breast ductal carcinoma in situ without evidence of disease * Prostatic intraepithelial neoplasia without evidence of prostate cancer * Adequately treated urothelial papillary noninvasive carcinoma or carcinoma in situ * Clinically relevant CNS pathology or event such as epilepsy, childhood or adult seizure, paresis, aphasia, stroke, severe brain injuries, dementia, Parkinson's disease, cerebellar disease, organic brain syndrome, or psychiatric conditions that preclude the use of high dose of corticosteroids * Current autoimmune disease or history of autoimmune disease with potential CNS involvement * Known infection with human immunodeficiency virus (HIV) * Known infection with chronic or active infection with hepatitis B (eg, hepatitis b surface \[HBs\] antigen reactive or quantifiable hepatitis b virus \[HBV\] viral load) or hepatitis C virus (HCV) (eg, HCV RNA \[qualitative\] is detected). Active hepatitis B and C based on the following results: * positive for hepatitis B surface antigen (HepBsAg) (indicative of chronic hepatitis B or recent acute hepatitis B) * negative HepBsAg and positive for hepatitis B core antibody: negative HBV DNA by PCR result is necessary to enroll. * positive Hepatitis C virus antibody (HepCAb): negative hepatitis C virus RNA by PCR result is necessary to enroll. * Participant with symptoms and/or clinical signs and/or radiographic and/or sonographic signs that indicate an acute or uncontrolled chronic infection. * Cancer chemotherapy for this newly diagnosed B cell ALL before the start of protocol-required therapy with the exception of IT chemotherapy or optional pre-phase (debulking) chemotherapy. Radiation to a spot lesion such as chloroma or lytic lesion of bone or vertebrae for pain or vertebral stabilization is allowed.

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Conditions

The condition(s) this trial relates to.

precursor B-cell acute lymphoblastic leukemia

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Newly diagnosed philadelphia (PH)-negative B-cell precursor acute lymphoblastic leukemia (ALL)

Contacts and locations

Locations

  • AZ Delta Campus Rumbeke

    Roeselare, 8800, Belgium

  • AZ Sint-Jan Brugge-Oostende AV

    Bruges, 8000, Belgium

  • Aalborg Universitetshospital

    Aalborg, 9000, Denmark

  • Aarhus Universitetshospital

    Aarhus N, 8200, Denmark

  • Adventist Health System/Sunbelt, Inc d/b/a AdventHealth Orlando

    Orlando, Florida, 32804, United States

  • Akita University Hospital

    Akita, Akita, 010-8543, Japan

  • Ankara Bilkent Sehir Hastanesi

    Ankara, 06800, Turkey (Türkiye)

  • Arthur J E Child Comprehensive Cancer Centre

    Calgary, Alberta, T2N 5G2, Canada

  • Attiko General University Hospital

    Athens, 12462, Greece

  • Austin Health, Austin Hospital

    Heidelberg, Victoria, 3084, Australia

  • Azienda Ospedaliera Policlinico Umberto I

    Roma, 00161, Italy

  • Azienda Ospedaliera Universitaria Consorziale Policlinico di Bari

    Bari, 70124, Italy

  • Azienda Ospedaliera Universitaria Integrata di Verona Ospedale G B Rossi Borgo Roma

    Verona, 37134, Italy

  • Azienda Ospedaliera di Perugia Ospedale Santa Maria della Misericordia

    Perugia, 06156, Italy

  • Azienda Ospedaliera di Rilievo Nazionale Antonio Cardarelli

    Naples, 80131, Italy

  • Azienda Ospedaliero Universitaria Citta della Salute e della Scienza di Torino

    Torino, 10126, Italy

  • Azienda Socio Sanitaria Territoriale Papa Giovanni xxiii

    Bergamo, 24127, Italy

  • Azienda Unita Sanitaria Locale LE Presidio Ospedaliero Vito Fazzi Polo Oncologico Giovanni Paolo II

    Lecce, 73100, Italy

  • Azienda Unita Sanitaria Locale Pescara Ospedale Civile Santo Spirito

    Pescara, 65124, Italy

  • Azienda Unità Locale Socio Sanitaria 3 Ospedale Dell Angelo

    Mestre (VE), 30174, Italy

  • Bagcilar Medipol Mega Universite Hastanesi

    Istanbul, 34214, Turkey (Türkiye)

  • Boca Clinical Trials Mexico SC

    Mexico City, Mexico City, 01120, Mexico

  • CEMTL Hopital Maisonneuve Rosemont

    Montreal, Quebec, H1T 2M4, Canada

  • Canberra Hospital

    Garran, Australian Capital Territory, 2605, Australia

  • Cancer Care Manitoba

    Winnipeg, Manitoba, R3H 0V9, Canada

  • Centre Hospitalier Regional Universitaire de Lille - Hopital Claude Huriez

    Lille, 59000, France

  • Centre Hospitalier Universitaire Archet 2

    Nice, 06202, France

  • Centre Hospitalier Universitaire de Bordeaux - Hopital Haut Leveque

    Pessac, 33604, France

  • Centre Hospitalier Universitaire de Dijon - Hopital du Bocage

    Dijon, 21000, France

  • Centre Hospitalier Universitaire de Liege - Sart Tilman

    Liège, 4000, Belgium

  • Centre Hospitalier Universitaire de Nancy - Hopital de Brabois

    Vandœuvre-lès-Nancy, 54511, France

  • Centre Hospitalier Universitaire de Nantes - Hopital Hotel Dieu

    Nantes, 44000, France

  • Centre Hospitalier Universitaire de Rennes

    Rennes, 35000, France

  • Centre Hospitalier Universitaire-Universite Catholique de Louvain Namur-Site Godinne

    Yvoir, 5530, Belgium

  • Centre Hospitalier de Versailles - Hopital Andre Mignot

    Le Chesnay, 78157, France

  • Centro Oncologico Internacional

    Mexico City, Mexico City, 01330, Mexico

  • Charite - Universitaetsmedizin Berlin, Campus Benjamin Franklin

    Berlin, 12203, Germany

  • China Medical University Hospital

    Taichung, 40458, Taiwan

  • Chonnam National University Hwasun Hospital

    Hwasun, 58128, South Korea

  • Chungnam National University Hospital

    Daejeon, 35015, South Korea

  • City of Hope National Medical Center

    Duarte, California, 91010, United States

  • Cleveland Clinic Foundation

    Cleveland, Ohio, 44195, United States

  • Clinica Alemana de Santiago

    Santiago, 7650729, Chile

  • Complejo Asistencial Universitario de Salamanca Hospital Universitario de Salamanca

    Salamanca, Castille and León, 37007, Spain

  • Debreceni Egyetem Klinikai Kozpont

    Debrecen, 4032, Hungary

  • Del-pesti Centrumkorhaz - Orszagos Hematologiai es Infektologiai Intezet

    Budapest, 1097, Hungary

  • Dokuz Eylul Universitesi Tip Fakultesi Hastanesi

    Izmir, 35340, Turkey (Türkiye)

  • Dong-A University Hospital

    Busan, 49201, South Korea

  • Evangelismos Hospital

    Athens, 10676, Greece

  • Fakultni nemocnice Brno

    Brno, 625 00, Czechia

  • Fakultni nemocnice Hradec Kralove

    Hradec Králové, 500 05, Czechia

  • Fiona Stanley Hospital

    Murdoch, Western Australia, 6150, Australia

  • Fondazione IRCCS Ca Granda Ospedale Maggiore Policlinico

    Milan, 20122, Italy

  • Fukushima Medical University Hospital

    Fukushima, Fukushima, 960-1295, Japan

  • Fundacao Amaral Carvalho

    Jaú, São Paulo, 17210-120, Brazil

  • Fundacion Arturo Lopez Perez

    Santiago, 7500921, Chile

  • General Hospital of Thessaloniki Georgios Papanikolaou

    Thessaloniki, 57010, Greece

  • Gunma Saiseikai Maebashi Hospital

    Maebashi, Gunma, 371-0821, Japan

  • Hacettepe Universitesi Tip Fakultesi Hastanesi

    Ankara, 06100, Turkey (Türkiye)

  • Hamilton Health Sciences - Juravinski Hospital and Cancer Centre

    Hamilton, Ontario, L8V 5C2, Canada

  • Hanusch Krankenhaus

    Vienna, 1140, Austria

  • Helsinki University Hospital

    Helsinki, 00029, Finland

  • Hematologica Alta Especialidad

    Huixquilucan, 52787, Mexico

  • Hemorio

    Rio de Janeiro, 22640-000, Brazil

  • Heves Varmegyei Markhot Ferenc Oktatokorhaz es Rendelointezet

    Eger, 3300, Hungary

  • Hopital Henri Mondor

    Créteil, 94010, France

  • Hopital Lyon Sud

    Pierre-Bénite, 69645, France

  • Hopital Saint Antoine

    Paris, 75012, France

  • Hopital Saint Louis

    Paris, 75010, France

  • Hosp Clin Fac Med Ribeirao Preto Usp

    Ribeirão Preto, São Paulo, 14048-900, Brazil

  • Hospital Universitari Vall d Hebron

    Barcelona, Catalonia, 08035, Spain

  • Hospital Universitari i Politecnic La Fe

    Valencia, Valencia, 46026, Spain

  • Hospital Universitario 12 de Octubre

    Madrid, 28041, Spain

  • Hospital Universitario Dr Jose Eleuterio Gonzalez

    Monterrey, Nuevo León, 64460, Mexico

  • Hospital Universitario Marques de Valdecilla

    Santander, Cantabria, 39008, Spain

  • Hospital Universitario Reina Sofia

    Córdoba, Andalusia, 14004, Spain

  • Hospital Universitario Virgen del Rocio

    Seville, Andalusia, 41013, Spain

  • Hospital das Clinicas da Universidade Federal de Goias

    Goiânia, Goiás, 74605-020, Brazil

  • Hospital de Base de Sao Jose do Rio Preto

    São Jose Do Rio Preto, São Paulo, 15090-000, Brazil

  • Hospital de Clinicas de Porto Alegre

    Porto Alegre, Rio Grande do Sul, 90035-003, Brazil

  • IRCCS Azienda Ospedaliera Metropolitana

    Genova, 16132, Italy

  • IRCCS Azienda Ospedaliero Universitaria di Bologna Policlinico di Sant Orsola

    Bologna, 40138, Italy

  • Igesd Instituto de Gestao Estrategica da Saude do Distrito Federal

    Brasília, Federal District, 70335-902, Brazil

  • Inmunocel

    Santiago, 7580206, Chile

  • Inselspital Bern

    Bern, 3010, Switzerland

  • Institut Catala d Oncologia Badalona Hospital Universitari Germans Trias i Pujol

    Badalona, Catalonia, 08916, Spain

  • Institut Catala d Oncologia Hospitalet Hospital Duran i Reynals

    L'Hospitalet de Llobregat, Catalonia, 08908, Spain

  • Institut Jules Bordet

    Anderlecht, 1070, Belgium

  • Institut Paoli Calmettes

    Marseille, 13009, France

  • Institut Universitaire du Cancer Toulouse Oncopole

    Toulouse, 31059, France

  • Instituto Cancer Sao Paulo Icesp

    São Paulo, 01246-000, Brazil

  • Instituto Nacional de Ciencias Medicas y Nutricion Salvador Zubiran

    Mexico City, 14080, Mexico

  • Instituto Portugues de Oncologia de Lisboa Francisco Gentil, EPE

    Lisbon, 1099-023, Portugal

  • Instituto Portugues de Oncologia do Porto Francisco Gentil, EPE

    Porto, 4200-072, Portugal

  • Institutul Clinic Fundeni

    Bucharest, 022328, Romania

  • Institutul Oncologic Prof Dr Ion Chiricuta

    Cluj-Napoca, 400015, Romania

  • Institutul Regional de Oncologie Iasi

    Iași, 700483, Romania

  • Jessa Ziekenhuis - Campus Virga Jesse

    Hasselt, 3500, Belgium

  • Jichi Medical University Hospital

    Shimotsuke-shi, Tochigi, 329-0498, Japan

  • Kanazawa University Hospital

    Kanazawa, Ishikawa-ken, 920-8641, Japan

  • Kindai University Hospital

    Sakai-shi, Osaka, 590-0197, Japan

  • Kings College Hospital

    London, SE5 9RS, United Kingdom

  • Klinikum der LMU Muenchen

    München, 81377, Germany

  • Kobe City Medical Center General Hospital

    Kobe, Hyōgo, 650-0047, Japan

  • Kurume University Hospital

    Kurume-shi, Fukuoka, 830-0011, Japan

  • Kyoto University Hospital

    Kyoto, Kyoto, 606-8507, Japan

  • Kyushu University Hospital

    Fukuoka, Fukuoka, 812-8582, Japan

  • Laiko General Hospital of Athens

    Athens, 11527, Greece

  • Linkou Chang Gung Memorial Hospital of Chang Gung Medical Foundation

    Taoyuan, 33305, Taiwan

  • Liverpool Hospital

    Liverpool, New South Wales, 2170, Australia

  • Medizinische Universitaet Graz

    Graz, 8036, Austria

  • Medizinische Universitaet Innsbruck

    Innsbruck, 6020, Austria

  • Memorial Antalya Hastanesi

    Antalya, 07025, Turkey (Türkiye)

  • Monash Medical Centre

    Clayton, Victoria, 3168, Australia

  • Nagasaki University Hospital

    Nagasaki, Nagasaki, 852-8501, Japan

  • Nagoya University Hospital

    Nagoya, Aichi-ken, 466-8560, Japan

  • Narodny onkologicky ustav

    Bratislava, 833 10, Slovakia

  • National Cheng Kung University Hospital

    Tainan, 70403, Taiwan

  • National Hospital Organization Okayama Medical Center

    Okayama, Okayama-ken, 701-1192, Japan

  • National Taiwan University Hospital

    Taipei, 10002, Taiwan

  • Nihon University Itabashi Hospital

    Itabashi-ku, Tokyo, 173-8610, Japan

  • North Estonia Medical Centre

    Tallinn, 13 419, Estonia

  • Odense Universitetshospital

    Odense, 5000, Denmark

  • Ondokuz Mayis Universitesi Tip Fakultesi Hastanesi

    Samsun, 55139, Turkey (Türkiye)

  • Ordensklinikum Linz Elisabethinen

    Linz, 4020, Austria

  • Osaka Metropolitan University Hospital

    Osaka, Osaka, 545-8586, Japan

  • Peter MacCallum Cancer Centre

    Melbourne, Victoria, 3000, Australia

  • Princess Alexandra Hospital

    Woolloongabba, Queensland, 4102, Australia

  • Princess Margaret Cancer Centre

    Toronto, Ontario, M5G 2M9, Canada

  • Princess Margaret Hospital

    Kowloon, Hong Kong

  • Pusan National University Hospital

    Busan, 49241, South Korea

  • Queen Elizabeth II, Health Sciences Centre

    Halifax, Nova Scotia, B3H 1V8, Canada

  • Queen Mary Hospital, The University of Hong Kong

    Hong Kong, Hong Kong

  • Rabin Medical Center - Beilinson Hospital

    Petah Tikva, 4941492, Israel

  • Rambam Medical Center

    Haifa, 3109601, Israel

  • Rigshospitalet

    København Ø, 2100, Denmark

  • Royal Adelaide Hospital

    Adelaide, South Australia, 5000, Australia

  • Royal Brisbane and Womens Hospital

    Herston, Queensland, 4029, Australia

  • Royal North Shore Hospital

    St Leonards, New South Wales, 2065, Australia

  • Royal Prince Alfred Hospital

    Camperdown, New South Wales, 2050, Australia

  • Sahlgrenska Universitetssjukhuset

    Gothenburg, 413 45, Sweden

  • Saint Francis Hospital, Inc

    Greenville, South Carolina, 29607, United States

  • Sapporo Hokuyu Hospital

    Sapporo, Hokkaido, 003-0006, Japan

  • Semmelweis Egyetem

    Budapest, 1088, Hungary

  • Seoul National University Hospital

    Seoul, 03080, South Korea

  • Severance Hospital Yonsei University Health System

    Seoul, 03722, South Korea

  • Shaare Zedek Medical Center

    Jerusalem, 9103102, Israel

  • Specialized Hospital for Active Treatment of Hematology Diseases EAD

    Sofia, 1797, Bulgaria

  • Spitalul Clinic Judetean de Urgenta Sibiu

    Sibiu, 550245, Romania

  • Spitalul Clinic Municipal Filantropia Craiova

    Craiova, 200143, Romania

  • Spitalul Universitar de Urgenta Bucuresti

    Bucharest, 050098, Romania

  • Szabolcs-Szatmar-Bereg Varmegyei Oktatokorhaz Nyiregyhazi Josa Andras Tagkorhaz

    Nyíregyháza, 4400, Hungary

  • Taichung Veterans General Hospital

    Taichung, 40705, Taiwan

  • Tartu University Hospital

    Tartu, 51014, Estonia

  • Tesshokai Kameda General Hospital

    Kamogawa-shi, Chiba, 296-8602, Japan

  • The Alfred Hospital

    Melbourne, Victoria, 3004, Australia

  • The Catholic University of Korea Seoul St Marys Hospital

    Seoul, 06591, South Korea

  • The Ottawa Hospital Cancer Centre

    Ottawa, Ontario, K1H 8L6, Canada

  • Tohoku University Hospital

    Sendai, Miyagi, 980-8574, Japan

  • Tokai University Hospital

    Isehara-shi, Kanagawa, 259-1193, Japan

  • Tokyo Metropolitan Komagome Hospital

    Bunkyo-ku, Tokyo, 113-8677, Japan

  • Tuen Mun Hospital

    New Territories, Hong Kong

  • Turku University Hospital

    Turku, 20521, Finland

  • Unidade Local de Saude de Coimbra, EPE

    Coimbra, 3004-561, Portugal

  • Unidade Local de Saude de Santa Maria, EPE - Hospital de Santa Maria

    Lisbon, 1649-035, Portugal

  • Unidade Local de Saude de Sao Jose, EPE - Hospital de Santo Antonio dos Capuchos

    Lisbon, 1169-050, Portugal

  • Universitaetsklinikum Augsburg

    Augsburg, 86156, Germany

  • Universitaetsklinikum Dresden

    Dresden, 01307, Germany

  • Universitaetsklinikum Duesseldorf

    Düsseldorf, 40225, Germany

  • Universitaetsklinikum Heidelberg

    Heidelberg, 69120, Germany

  • Universitaetsklinikum Jena

    Jena, 07747, Germany

  • Universitaetsklinikum Schleswig-Holstein - Kiel

    Kiel, 24105, Germany

  • Universitair Medisch Centrum Groningen

    Groningen, 9713 GZ, Netherlands

  • Universitair Ziekenhuis Antwerpen

    Edegem, 2650, Belgium

  • Universitair Ziekenhuis Gent

    Ghent, 9000, Belgium

  • Universite Catholique de Louvain Cliniques Universitaires Saint Luc

    Brussels, 1200, Belgium

  • University College London

    London, NW1 2PG, United Kingdom

  • University Hospital of Heraklion

    Heraklion, 71500, Greece

  • University Hospital of Ioannina

    Ioannina, 45500, Greece

  • University Hospital of Larissa

    Larissa, 41110, Greece

  • University Hospital of Patras

    Pátrai, 26504, Greece

  • University Multiprofile Hospital for Active Treatment Sveti Georgi EAD

    Plovdiv, 40002, Bulgaria

  • University of California Irvine

    Orange, California, 92868-3201, United States

  • University of California San Francisco

    San Francisco, California, 94143, United States

  • University of Fukui Hospital

    Yoshida-gun, Fukui, 910-1193, Japan

  • University of Texas MD Anderson Cancer Center

    Houston, Texas, 77030, United States

  • Univerzitna nemocnica Bratislava, Nemocnica sv Cyrila a Metoda

    Bratislava, 851 07, Slovakia

  • Ustav hematologie a krevni transfuze

    Prague, 128 20, Czechia

  • Vancouver General Hospital, Gordon and Leslie Diamond Health Care Centre

    Vancouver, British Columbia, V5Z 1M9, Canada

  • Westmead Hospital

    Westmead, New South Wales, 2145, Australia

  • Yamagata University Hospital

    Yamagata, Yamagata, 990-9585, Japan

  • Yokohama City University Medical Center

    Yokohama, Kanagawa, 232-0024, Japan