New combo aims to fight tough bladder cancer

NCT ID NCT04164082

Disease control Sponsor: National Cancer Institute (NCI) Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Aug 12, 2026 · Updated 4 times

Summary

This phase II trial is testing whether adding the immunotherapy drug pembrolizumab to the chemotherapy drug gemcitabine can help patients with a type of bladder cancer that does not respond to the usual BCG treatment. The study involves 161 participants and looks at how many patients achieve a complete response and how long the cancer stays away. The goal is to find a more effective treatment option for this hard-to-treat cancer.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance: gemcitabine and pembrolizumab
What this could lead to: If it works, this combination could offer a new treatment option for patients whose bladder cancer does not respond to standard BCG therapy, potentially delaying cancer recurrence.
What could go wrong: This is a phase II trial with 161 participants, so results are still preliminary. The combination may not improve outcomes over gemcitabine alone, and side effects from chemotherapy and immunotherapy can be significant.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Phase 2

Tests whether the treatment actually works, and watches for side effects, in a larger group.

Participants

About 161 people

The number the study aims to enrol. It can still change while the study runs.

Started

Mar 2020

Expected to finish

Dec 2026

An estimate. End dates often move.

Lead sponsor

A government research agency

The lead sponsor is the US National Institutes of Health.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 years and older

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * High grade Ta, T1 or CIS urothelial carcinoma. Accrual of patients with Ta or T1 disease may be closed to ensure adequate patients enrollment to meet the primary endpoint * Persistent disease (defined as not achieving disease free status) after completing therapy with at least induction BCG (\>= 5 doses) and the first round of maintenance or second induction course (\>= 2 doses). The subsequent round of BCG, either maintenance or repeat induction, must be given within 6 months of initial induction BCG * Persistent high risk NMIBC (T1, high grade Ta and/or CIS) must be within 9 months of the last BCG instillation despite having received adequate BCG as defined above. * Registration must be within 12 months of last BCG instillation * High grade T1 after completing therapy with at least induction BCG (\>= 5 doses) or after completing therapy with at least induction BCG (\>= 5 doses) and first round of maintenance or second induction course (\>= 2 doses). The subsequent round of BCG, either maintenance or repeat induction, must be given within 6 months of initial induction BCG * Disease recurrence (T1) must be within 9 months of the last BCG instillation despite having received adequate BCG as defined above * Registration must be within 12 months of last BCG instillation * Mixed variant histology (adenocarcinoma, squamous cell carcinoma) is eligible, but pure variant histology is ineligible * Patients who are disease free at 6 months after starting BCG but have high grade recurrence (T1, Ta, CIS) while on maintenance therapy would be eligible * The recurrence must be within 6 months of the last BCG dose. * Registration must be within 12 months of last maintenance BCG instillation * Patients must be deemed unfit for radical cystectomy by the treating physician or refuse radical cystectomy * All patients must have histologically confirmed urothelial cancer of the bladder within 60 days prior to registration * All visible tumor must be completely resected 60 days prior to registration (residual pure CIS is permitted) * All patients must have had a cystoscopy (or TURBT with complete resection) without papillary tumor and negative urinary cytology within 28 days of registration (positive cytology is allowed in patients with CIS) * All patients with T1 tumors must undergo a re-staging transurethral resection of bladder tumor (TURBT) within 60 days of registration * There must be uninvolved muscularis propria present in the re-staging TURBT. The initial TURBT prior to re-staging TURBT may be greater than 60 days prior to registration * Patients must have had imaging with CT or MRI abdomen/pelvis within 90 days of registration demonstrating no evidence of metastasis * Patients cannot have had a history of urothelial carcinoma in the ureters or prostatic urethra 24 months prior to registration * Patients must not be currently participating in or have participated in a study of an investigational agent or have used an investigational device within 4 weeks prior to study registration * Note: Participants who have entered the follow-up phase of an investigational study may participate as long as it has been more than 4 weeks after the last dose of the previous investigational agent at time of registration * Patients must not have prior therapy with an anti-PD-1, anti-PD-L1, or anti PD L2 agent or with an agent directed to another stimulatory or co-inhibitory T-cell receptor (e.g., CTLA-4, OX 40, CD137) * Patients must not have undergone prior allogeneic hematopoietic stem cell transplantation within the last 5 years prior to registration. (Participants who have had a transplant greater than 5 years ago are eligible as long as there are no symptoms of graft versus host disease \[GVHD\]) * Patients must not have received prior systemic anti-cancer therapy including investigational agents within 4 weeks prior to treatment * Note: Participants must have recovered from all adverse events (AEs) due to previous therapies to =\< grade 1 or baseline. Participants with =\< grade 2 neuropathy may be eligible * Note: If participant received major surgery, they must have recovered adequately from the toxicity and/or complications from the intervention prior to starting study treatment * Patients must not have received prior radiotherapy within 2 weeks of study registration. Participants must have recovered from all radiation-related toxicities, not require corticosteroids, and not have had radiation pneumonitis * Patients must not have received radiation therapy to the lung that is \> 30 Gy within 6 months prior to trial registration * Not pregnant and not nursing, because this study involves an agent that has known genotoxic, mutagenic and teratogenic effects * Women and men of reproductive potential should agree to use an appropriate method of birth control throughout their participation in this study due to the teratogenic potential of the therapy utilized in this trial. Include as applicable: Appropriate methods of birth control include abstinence, oral contraceptives, implantable hormonal contraceptives or double barrier method (diaphragm plus condom) * A woman of childbearing potential (WOCBP) must not have a positive urine pregnancy test within 7 days prior to registration. If the urine test is positive or cannot be confirmed as negative, a serum pregnancy test will be required * Patients must not be pregnant or breastfeeding or expecting to conceive or father children within the projected duration of the study, starting with registration through the last dose of treatment * Age \>= 18 years * Eastern Cooperative Oncology Group (ECOG) performance status 0-2 * Absolute neutrophil count (ANC) \>= 1,500/mm\^3 * Platelet count \>= 100,000/mm\^3 * Hemoglobin \>= 9.0 g/dL * Creatinine =\< 1.5 x upper limit of normal (ULN) * In patients with creatinine \> 1.5 x ULN, if measured or calculated creatinine clearance \> 30 mL/min, then patient is eligible * Total bilirubin =\< 1.5 x ULN * In patients with a total bilirubin \> 1.5 x ULN, if direct bilirubin \< 1.0 X ULN, then patient is eligible * Aspartate aminotransferase (AST)/ alanine aminotransferase (ALT) =\< 2.5 x ULN * Patients must not have had an active autoimmune disease requiring systemic treatment within 24 months prior to registration. Autoimmune diseases include, but not limited to, lupus erythematosus, rheumatoid arthritis, inflammatory bowel disease, antiphospholipid syndrome, Wegener's granulomatosis, Sjogren's syndrome, Bell's palsy, Guillain-Barre syndrome, multiple sclerosis, autoimmune thyroid disease, vasculitis, or glomerulonephritis * Patients must not have a diagnosis of immunodeficiency or is receiving chronic systemic steroid therapy (in dosing exceeding 10 mg daily of prednisone equivalent) or any other form of immunosuppressive therapy within 7 days prior to registration * Note: Replacement therapy (e.g., thyroxine, insulin, or physiologic corticosteroid replacement therapy for adrenal or pituitary insufficiency) is not considered a form of systemic treatment and is allowed * Patients must not have a known psychiatric or substance abuse disorder that would interfere with the participant's ability to cooperate with the requirements of the study * Patients must not have active tuberculosis * Patients must not have been treated with antibiotics for an active infection within 14 days prior to registration. Prophylactic antibiotics are permitted. Treatment for a urinary tract infection (UTI) is allowed but must be deemed adequately treated by the treating physician prior the start of cycle 1 (C1) day 1 (D1) * Patients must not have a history of idiopathic pulmonary fibrosis or organizing pneumonia * Patients must not have a history of (non-infectious) pneumonitis that required steroids or have current pneumonitis * Patients with human immunodeficiency virus (HIV) are eligible with the following: * On effective anti-retroviral therapy with undetectable viral load within 6 months of registration * HIV-infected participants must not have a history of Kaposi sarcoma and/or multicentric Castleman disease * Patients must not have a known additional malignancy that has had progression or has required active treatment in the last three years. Exceptions include basal or squamous cell carcinoma of the skin that has undergone potentially curative therapy or in situ cervical cancer. A history of prostate cancer that was treated with definitive intent is allowed, provided that the prostate-specific antigen (PSA) is undetectable for at least 1 year while off androgen deprivation therapy * Patients must not have known active CNS metastases and/or carcinomatous meningitis. Participants with previously treated brain metastases may participate provided they are radiologically stable, i.e., without evidence of progression for at least 4 weeks by repeat imaging (note that the repeat imaging should be performed during study screening), clinically stable and without requirement of steroid treatment for at least 14 days prior to first dose of study treatment * Patients must not have severe hypersensitivity (\>= grade 3) to pembrolizumab and/or any of its excipients * Patients must not have an active infection requiring systemic therapy * Patients must not have a known history of hepatitis B (defined as hepatitis B surface antigen \[HBsAg\] reactive) or known active hepatitis C virus (defined as hepatitis C virus \[HCV\] ribonucleic acid \[RNA\] \[qualitative\] is detected) infection * Note: No testing for hepatitis B and hepatitis C is required unless mandated by a local health authority * Patients must not have received live vaccines within 30 days of study drug administration. Examples of live vaccines include, but are not limited to, the following: measles, mumps, rubella, varicella/zoster (chicken pox), yellow fever, rabies, Bacillus Calmette-Guerin (BCG), and typhoid vaccine. Seasonal influenza vaccines for injection are generally killed virus vaccines and are allowed; however, intranasal influenza vaccines (e.g., FluMist®) are live attenuated vaccines and are not allowed. COVID-19 vaccinations are permitted

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Conditions

The condition(s) this trial relates to.

bladder carcinoma in situ non-invasive bladder urothelial carcinoma Urinary Bladder Neoplasms

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Bladder flat urothelial carcinoma in situ Non-muscle invasive bladder urothelial carcinoma Stage 0A bladder cancer ajcc V8 Stage 0IS bladder cancer ajcc V8 Stage I bladder cancer ajcc V8

Contacts and locations

Locations

Abbott-Northwestern Hospital

Minneapolis, Minnesota, 55407, United States
Advanced Breast Care Center PLLC

Warren, Michigan, 48088, United States
Alaska Breast Care and Surgery LLC

Anchorage, Alaska, 99508, United States
Alaska Oncology and Hematology LLC

Anchorage, Alaska, 99508, United States
Alaska Women's Cancer Care

Anchorage, Alaska, 99508, United States
American Fork Hospital / Huntsman Intermountain Cancer Center

American Fork, Utah, 84003, United States
Anchorage Associates in Radiation Medicine

Anchorage, Alaska, 98508, United States
Anchorage Oncology Centre

Anchorage, Alaska, 99508, United States
Anchorage Radiation Therapy Center

Anchorage, Alaska, 99504, United States
Armes Family Cancer Center

Findlay, Ohio, 45840, United States
Arnot Ogden Medical Center/Falck Cancer Center

Elmira, New York, 14905, United States
Atrium Medical Center-Middletown Regional Hospital

Franklin, Ohio, 45005-1066, United States
Audie L Murphy VA Hospital

San Antonio, Texas, 78229, United States
Banner North Colorado Medical Center

Greeley, Colorado, 80631, United States
Banner North Colorado Medical Center - Loveland Campus

Loveland, Colorado, 80539, United States
Bay Area Hospital

Coos Bay, Oregon, 97420, United States
Baylor College of Medicine/Dan L Duncan Comprehensive Cancer Center

Houston, Texas, 77030, United States
Beacon Kalamazoo

Kalamazoo, Michigan, 49048, United States
Beacon Kalamazoo Cancer Center

Kalamazoo, Michigan, 49009, United States
Benefis Sletten Cancer Institute

Great Falls, Montana, 59405, United States
Bhadresh Nayak MD PC-Sterling Heights

Sterling Heights, Michigan, 48312, United States
Billings Clinic Cancer Center

Billings, Montana, 59101, United States
Billings Clinic-Cody

Cody, Wyoming, 82414, United States
Blanchard Valley Hospital

Findlay, Ohio, 45840, United States
Boulder Community Foothills Hospital

Boulder, Colorado, 80303, United States
Bozeman Health Deaconess Hospital

Bozeman, Montana, 59715, United States
Bronson Battle Creek

Battle Creek, Michigan, 49017, United States
Bronson Methodist Hospital

Kalamazoo, Michigan, 49007, United States
Cambridge Medical Center

Cambridge, Minnesota, 55008, United States
Cancer Care Center of O'Fallon

O'Fallon, Illinois, 62269, United States
Cancer Care Specialists of Illinois - Decatur

Decatur, Illinois, 62526, United States
Cancer Center at Saint Joseph's

Phoenix, Arizona, 85004, United States
Cancer Center of Colorado at Sloan's Lake

Denver, Colorado, 80204, United States
Cancer Center of Western Wisconsin

New Richmond, Wisconsin, 54017, United States
Cancer Center-Metro Medical Center Bayamon

Bayamón, 00959-5060, Puerto Rico
Cancer Hematology Centers - Flint

Flint, Michigan, 48503, United States
Cancer and Hematology Centers of Western Michigan - Norton Shores

Norton Shores, Michigan, 49444, United States
Caro Cancer Center

Caro, Michigan, 48723, United States
Castle Medical Center

Kailua, Hawaii, 96734, United States
Cedars-Sinai Medical Center

Los Angeles, California, 90048, United States
Central Care Cancer Center - Bolivar

Bolivar, Missouri, 65613, United States
Central Care Cancer Center - Garden City

Garden City, Kansas, 67846, United States
Central Care Cancer Center - Great Bend

Great Bend, Kansas, 67530, United States
Centralia Oncology Clinic

Centralia, Illinois, 62801, United States
Centro Comprensivo de Cancer de UPR

San Juan, 00927, Puerto Rico
Chelsea Hospital

Chelsea, Michigan, 48118, United States
Cheyenne Regional Medical Center-West

Cheyenne, Wyoming, 82001, United States
Clackamas Radiation Oncology Center

Clackamas, Oregon, 97015, United States
Colorado Blood Cancer Institute

Denver, Colorado, 80218, United States
Community Hospital of Anaconda

Anaconda, Montana, 59711, United States
Community Medical Center

Missoula, Montana, 59804, United States
Corewell Health Grand Rapids Hospitals - Butterworth Hospital

Grand Rapids, Michigan, 49503, United States
Corewell Health Grand Rapids Hospitals - Helen DeVos Children's Hospital

Grand Rapids, Michigan, 49503, United States
Corewell Health Lakeland Hospitals - Marie Yeager Cancer Center

Saint Joseph, Michigan, 49085, United States
Corewell Health Lakeland Hospitals - Niles Hospital

Niles, Michigan, 49120, United States
Corewell Health Lakeland Hospitals - Saint Joseph Hospital

Saint Joseph, Michigan, 49085, United States
Corewell Health Reed City Hospital

Reed City, Michigan, 49677, United States
Cox Cancer Center Branson

Branson, Missouri, 65616, United States
CoxHealth South Hospital

Springfield, Missouri, 65807, United States
Crossroads Cancer Center

Effingham, Illinois, 62401, United States
Dartmouth Hitchcock Medical Center/Dartmouth Cancer Center

Lebanon, New Hampshire, 03756, United States
Dayton Physician LLC - Englewood

Dayton, Ohio, 45415, United States
Dayton Physicians LLC - Troy

Troy, Ohio, 45373, United States
Dayton Physicians LLC-Atrium

Franklin, Ohio, 45005, United States
Dayton Physicians LLC-Miami Valley South

Centerville, Ohio, 45459, United States
Dayton Physicians LLC-Wayne

Greenville, Ohio, 45331, United States
Decatur Memorial Hospital

Decatur, Illinois, 62526, United States
Doctors Cancer Center

Manati, 00674, Puerto Rico
East Jefferson General Hospital

Metairie, Louisiana, 70006, United States
FHP Health Center-Guam

Tamuning, 96913, Guam
Fairbanks Memorial Hospital

Fairbanks, Alaska, 99701, United States
Fairview Clinics and Surgery Center Maple Grove

Maple Grove, Minnesota, 55369, United States
Fairview Lakes Medical Center

Wyoming, Minnesota, 55092, United States
Fairview Northland Medical Center

Princeton, Minnesota, 55371, United States
Fairview Ridges Hospital

Burnsville, Minnesota, 55337, United States
Fairview Southdale Hospital

Edina, Minnesota, 55435, United States
First Dayton Cancer Care

Kettering, Ohio, 45420, United States
Freeman Health System

Joplin, Missouri, 64804, United States
Genesee Hematology Oncology PC

Flint, Michigan, 48503, United States
Genesys Hurley Cancer Institute

Flint, Michigan, 48503, United States
Gibbs Cancer Center-Gaffney

Gaffney, South Carolina, 29341, United States
Gibbs Cancer Center-Pelham

Greer, South Carolina, 29651, United States
Good Samaritan Hospital - Cancer Centers of Colorado

Lafayette, Colorado, 80026, United States
Great Falls Clinic

Great Falls, Montana, 59405, United States
Greater Dayton Cancer Center

Kettering, Ohio, 45409, United States
HIMA San Pablo Oncologic Hospital

Caguas, 00726, Puerto Rico
Hackensack University Medical Center

Hackensack, New Jersey, 07601, United States
Hawaii Cancer Care - Westridge

‘Aiea, Hawaii, 96701, United States
Hawaii Cancer Care Inc - Waterfront Plaza

Honolulu, Hawaii, 96813, United States
Hawaii Cancer Care Inc-Liliha

Honolulu, Hawaii, 96817, United States
Hawaii Diagnostic Radiology Services LLC

Honolulu, Hawaii, 96817, United States
Health Partners Inc

Minneapolis, Minnesota, 55454, United States
Heartland Regional Medical Center

Saint Joseph, Missouri, 64506, United States
Hematology Oncology Consultants-Clarkston

Clarkston, Michigan, 48346, United States
Hennepin County Medical Center

Minneapolis, Minnesota, 55415, United States
Henry Ford Health Saint John Hospital

Detroit, Michigan, 48236, United States
Henry Ford Health Warren Hospital

Warren, Michigan, 48093, United States
Henry Ford Madison Heights Hospital - Breast

Warren, Michigan, 48093, United States
Henry Ford River District Hospital

East China Township, Michigan, 48054, United States
Henry Ford Rochester Hospital

Rochester Hills, Michigan, 48309, United States
Henry Ford Saint John Hospital - Academic

Grosse Pointe Woods, Michigan, 48236, United States
Henry Ford Saint John Hospital - Breast

Grosse Pointe Woods, Michigan, 48236, United States
Henry Ford Saint John Hospital - Macomb Medical

Macomb, Michigan, 48044, United States
Henry Ford Saint John Hospital - Van Elslander

Grosse Pointe Woods, Michigan, 48236, United States
Henry Ford Warren Hospital - Breast Macomb

Macomb, Michigan, 48044, United States
Henry Ford Warren Hospital - GLCMS

Warren, Michigan, 48093, United States
Hickman Cancer Center

Adrian, Michigan, 49221, United States
Holy Cross Hospital

Fort Lauderdale, Florida, 33308, United States
Hope Cancer Center

Pontiac, Michigan, 48341, United States
Hope Cancer Clinic

Livonia, Michigan, 48154, United States
Hurley Medical Center

Flint, Michigan, 48503, United States
Huron Gastroenterology PC

Ypsilanti, Michigan, 48106, United States
Idaho Urologic Institute-Meridian

Meridian, Idaho, 83642, United States
Illinois CancerCare - Washington

Washington, Illinois, 61571, United States
Illinois CancerCare-Bloomington

Bloomington, Illinois, 61704, United States
Illinois CancerCare-Canton

Canton, Illinois, 61520, United States
Illinois CancerCare-Carthage

Carthage, Illinois, 62321, United States
Illinois CancerCare-Dixon

Dixon, Illinois, 61021, United States
Illinois CancerCare-Eureka

Eureka, Illinois, 61530, United States
Illinois CancerCare-Galesburg

Galesburg, Illinois, 61401, United States
Illinois CancerCare-Kewanee Clinic

Kewanee, Illinois, 61443, United States
Illinois CancerCare-Macomb

Macomb, Illinois, 61455, United States
Illinois CancerCare-Ottawa Clinic

Ottawa, Illinois, 61350, United States
Illinois CancerCare-Pekin

Pekin, Illinois, 61554, United States
Illinois CancerCare-Peoria

Peoria, Illinois, 61615, United States
Illinois CancerCare-Peru

Peru, Illinois, 61354, United States
Illinois CancerCare-Princeton

Princeton, Illinois, 61356, United States
Indu and Raj Soin Medical Center

Beavercreek, Ohio, 45431, United States
Instituto Oncologia Moderna Ponce

Ponce, 00716, Puerto Rico
Intermountain Health Lutheran Hospital

Wheat Ridge, Colorado, 80401, United States
Intermountain Medical Center

Murray, Utah, 84107, United States
Island Urology

Honolulu, Hawaii, 96813, United States
Jefferson Healthcare

Port Townsend, Washington, 98368, United States
Kadlec Clinic Hematology and Oncology

Kennewick, Washington, 99336, United States
Kapiolani Medical Center for Women and Children

Honolulu, Hawaii, 96826, United States
Katmai Oncology Group

Anchorage, Alaska, 99508, United States
Kettering Medical Center

Kettering, Ohio, 45429, United States
Kootenai Clinic Cancer Services - Post Falls

Post Falls, Idaho, 83854, United States
Kootenai Clinic Cancer Services - Sandpoint

Sandpoint, Idaho, 83864, United States
Kootenai Health - Coeur d'Alene

Coeur d'Alene, Idaho, 83814, United States
Kuakini Medical Center

Honolulu, Hawaii, 96817, United States
LDS Hospital

Salt Lake City, Utah, 84143, United States
LSU Healthcare Network / Metairie Multi-Specialty Clinic

Metairie, Louisiana, 70006, United States
Lakeview Hospital

Stillwater, Minnesota, 55082, United States
Lehigh Valley Hospital - Muhlenberg

Bethlehem, Pennsylvania, 18017, United States
Lehigh Valley Hospital-Cedar Crest

Allentown, Pennsylvania, 18103, United States
Lehigh Valley Hospital-Hazleton

Hazleton, Pennsylvania, 18201, United States
Logan Health Medical Center

Kalispell, Montana, 59901, United States
Logan Regional Hospital

Logan, Utah, 84321, United States
Louisiana Hematology Oncology Associates LLC

Baton Rouge, Louisiana, 70809, United States
Louisiana State University Health Science Center

New Orleans, Louisiana, 70112, United States
Lowell General Hospital

Lowell, Massachusetts, 01854, United States
Loyola University Medical Center

Maywood, Illinois, 60153, United States
MU Health - University Hospital/Ellis Fischel Cancer Center

Columbia, Missouri, 65212, United States
MU Health Care Goldschmidt Cancer Center

Jefferson City, Missouri, 65109, United States
Macomb Hematology Oncology PC

Warren, Michigan, 48093, United States
Marjorie Weinberg Cancer Center at Loyola-Gottlieb

Melrose Park, Illinois, 60160, United States
Marshfield Medical Center - Minocqua

Minocqua, Wisconsin, 54548, United States
Marshfield Medical Center - Weston

Weston, Wisconsin, 54476, United States
Marshfield Medical Center-EC Cancer Center

Eau Claire, Wisconsin, 54701, United States
Marshfield Medical Center-Marshfield

Marshfield, Wisconsin, 54449, United States
Marshfield Medical Center-Rice Lake

Rice Lake, Wisconsin, 54868, United States
Marshfield Medical Center-River Region at Stevens Point

Stevens Point, Wisconsin, 54482, United States
Mary Bird Perkins Cancer Center

Baton Rouge, Louisiana, 70809, United States
Mary Bird Perkins Cancer Center - Metairie

Metairie, Louisiana, 70002, United States
Mayo Clinic Hospital in Arizona

Phoenix, Arizona, 85054, United States
Mayo Clinic in Arizona

Scottsdale, Arizona, 85259, United States
McKay-Dee Hospital Center

Ogden, Utah, 84403, United States
MedStar Georgetown University Hospital

Washington D.C., District of Columbia, 20007, United States
MedStar Washington Hospital Center

Washington D.C., District of Columbia, 20010, United States
Medical College of Wisconsin

Milwaukee, Wisconsin, 53226, United States
Memorial Hospital of Carbondale

Carbondale, Illinois, 62902, United States
Memorial Hospital of South Bend

South Bend, Indiana, 46601, United States
Memorial Sloan Kettering Basking Ridge

Basking Ridge, New Jersey, 07920, United States
Memorial Sloan Kettering Bergen

Montvale, New Jersey, 07645, United States
Memorial Sloan Kettering Cancer Center

New York, New York, 10065, United States
Memorial Sloan Kettering Commack

Commack, New York, 11725, United States
Memorial Sloan Kettering Monmouth

Middletown, New Jersey, 07748, United States
Memorial Sloan Kettering Nassau

Uniondale, New York, 11553, United States
Memorial Sloan Kettering Westchester

Harrison, New York, 10604, United States
Mercy Cancer Center - Cape Girardeau

Cape Girardeau, Missouri, 63703, United States
Mercy Clinic-Rolla-Cancer and Hematology

Rolla, Missouri, 65401, United States
Mercy Health - Perrysburg Hospital

Perrysburg, Ohio, 43551, United States
Mercy Health - Saint Anne Hospital

Toledo, Ohio, 43623, United States
Mercy Hospital

Coon Rapids, Minnesota, 55433, United States
Mercy Hospital Fort Smith

Fort Smith, Arkansas, 72903, United States
Mercy Hospital Joplin

Joplin, Missouri, 64804, United States
Mercy Hospital Oklahoma City

Oklahoma City, Oklahoma, 73120, United States
Mercy Hospital Saint Louis

St Louis, Missouri, 63141, United States
Mercy Hospital South

St Louis, Missouri, 63128, United States
Mercy Hospital Springfield

Springfield, Missouri, 65804, United States
Mercy Hospital Washington

Washington, Missouri, 63090, United States
Mercy Infusion Center - Chippewa

St Louis, Missouri, 63109, United States
Mercy Medical Center

Springfield, Massachusetts, 01104, United States
Mercy Oncology and Hematology - Clayton-Clarkson

Ballwin, Missouri, 63011, United States
Methodist Medical Center of Illinois

Peoria, Illinois, 61636, United States
Miami Valley Hospital

Dayton, Ohio, 45409, United States
Miami Valley Hospital North

Dayton, Ohio, 45415, United States
Miami Valley Hospital South

Centerville, Ohio, 45459, United States
Michigan Healthcare Professionals Pontiac

Pontiac, Michigan, 48341, United States
Minnesota Oncology - Burnsville

Burnsville, Minnesota, 55337, United States
Minnesota Oncology Hematology PA-Maplewood

Maplewood, Minnesota, 55109, United States
Minnesota Oncology Hematology PA-Woodbury

Woodbury, Minnesota, 55125, United States
Missouri Baptist Medical Center

St Louis, Missouri, 63131, United States
Missouri Baptist Sullivan Hospital

Sullivan, Missouri, 63080, United States
Monticello Cancer Center

Monticello, Minnesota, 55362, United States
Mountain Blue Cancer Care Center - Swedish

Englewood, Colorado, 80113, United States
MultiCare Auburn Medical Center

Auburn, Washington, 98001, United States
MultiCare Deaconess Cancer and Blood Specialty Center - Downtown

Spokane, Washington, 99204, United States
MultiCare Deaconess Cancer and Blood Specialty Center - North

Spokane, Washington, 99218, United States
MultiCare Deaconess Cancer and Blood Specialty Center - Valley

Spokane Valley, Washington, 99216, United States
MultiCare Gig Harbor Medical Park

Gig Harbor, Washington, 98335, United States
MultiCare Good Samaritan Hospital

Puyallup, Washington, 98372, United States
MultiCare Tacoma General Hospital

Tacoma, Washington, 98405, United States
Munson Medical Center

Traverse City, Michigan, 49684, United States
MyMichigan Medical Center Saginaw

Saginaw, Michigan, 48601, United States
MyMichigan Medical Center Tawas

Tawas City, Michigan, 48764, United States
NYP/Weill Cornell Medical Center

New York, New York, 10065, United States
National Jewish Health-Main Campus

Denver, Colorado, 80206, United States
National Jewish Health-Northern Hematology Oncology

Thornton, Colorado, 80260, United States
National Jewish Health-Western Hematology Oncology

Golden, Colorado, 80401, United States
Neurosurgeons of New Jersey-Ridgewood

Ridgewood, New Jersey, 07450, United States
New Ulm Medical Center

New Ulm, Minnesota, 56073, United States
Newland Medical Associates-Clarkston

Clarkston, Michigan, 48346, United States
Newland Medical Associates-Pontiac

Pontiac, Michigan, 48341, United States
North Grove Medical Park

Spartanburg, South Carolina, 29303, United States
North Memorial Medical Health Center

Robbinsdale, Minnesota, 55422, United States
OSF Saint Anthony's Health Center

Alton, Illinois, 62002, United States
Oncology Hematology Associates of Saginaw Valley PC

Saginaw, Michigan, 48604, United States
Oncology Hematology Care Inc-Kenwood

Cincinnati, Ohio, 45236, United States
Orion Cancer Care

Findlay, Ohio, 45840, United States
Pacific Gynecology Specialists

Seattle, Washington, 98104, United States
Pali Momi Medical Center

‘Aiea, Hawaii, 96701, United States
Park Nicollet Clinic - Saint Louis Park

Saint Louis Park, Minnesota, 55416, United States
Parkland Health Center - Farmington

Farmington, Missouri, 63640, United States
PeaceHealth Saint John Medical Center

Longview, Washington, 98632, United States
PeaceHealth Saint Joseph Medical Center

Bellingham, Washington, 98225, United States
PeaceHealth Southwest Medical Center

Vancouver, Washington, 98664, United States
PeaceHealth United General Medical Center

Sedro-Woolley, Washington, 98284, United States
Phelps Health Delbert Day Cancer Institute

Rolla, Missouri, 65401, United States
Pocono Medical Center

East Stroudsburg, Pennsylvania, 18301, United States
Presbyterian - Saint Lukes Medical Center - Health One

Denver, Colorado, 80218, United States
ProHealth D N Greenwald Center

Mukwonago, Wisconsin, 53149, United States
ProHealth Oconomowoc Memorial Hospital

Oconomowoc, Wisconsin, 53066, United States
ProHealth Waukesha Memorial Hospital

Waukesha, Wisconsin, 53188, United States
Providence Alaska Medical Center

Anchorage, Alaska, 99508, United States
Providence Cancer Institute Clackamas Clinic

Clackamas, Oregon, 97015, United States
Providence Newberg Medical Center

Newberg, Oregon, 97132, United States
Providence Portland Medical Center

Portland, Oregon, 97213, United States
Providence Regional Cancer Partnership

Everett, Washington, 98201, United States
Providence Regional Cancer System-Aberdeen

Aberdeen, Washington, 98520, United States
Providence Regional Cancer System-Centralia

Centralia, Washington, 98531, United States
Providence Regional Cancer System-Lacey

Lacey, Washington, 98503, United States
Providence Regional Cancer System-Shelton

Shelton, Washington, 98584, United States
Providence Regional Cancer System-Yelm

Yelm, Washington, 98597, United States
Providence Saint Joseph Medical Center/Disney Family Cancer Center

Burbank, California, 91505, United States
Providence Saint Mary Regional Cancer Center

Walla Walla, Washington, 99362, United States
Providence Saint Vincent Medical Center

Portland, Oregon, 97225, United States
Puerto Rico Hematology Oncology Group

Bayamón, 00961, Puerto Rico
Queen's Cancer Cenrer - POB I

Honolulu, Hawaii, 96813, United States
Queen's Cancer Center - Kuakini

Honolulu, Hawaii, 96817, United States
Queen's Cancer Center - Pearlridge

‘Aiea, Hawaii, 96701, United States
Queen's Medical Center

Honolulu, Hawaii, 96813, United States
Ralph H Johnson VA Medical Center

Charleston, South Carolina, 29401, United States
Regions Hospital

Saint Paul, Minnesota, 55101, United States
Reid Health

Richmond, Indiana, 47374, United States
Rice Memorial Hospital

Willmar, Minnesota, 56201, United States
Ridgeview Medical Center

Waconia, Minnesota, 55387, United States
Riverton Hospital

Riverton, Utah, 84065, United States
Rocky Mountain Cancer Centers - Centennial

Centennial, Colorado, 80112, United States
Rocky Mountain Cancer Centers - Swedish

Englewood, Colorado, 80113, United States
Rocky Mountain Cancer Centers-Aurora

Aurora, Colorado, 80012, United States
Rocky Mountain Cancer Centers-Boulder

Boulder, Colorado, 80304, United States
Rocky Mountain Cancer Centers-Lakewood

Lakewood, Colorado, 80228, United States
Rocky Mountain Cancer Centers-Littleton

Littleton, Colorado, 80120, United States
Rocky Mountain Cancer Centers-Midtown

Denver, Colorado, 80218, United States
Rocky Mountain Cancer Centers-Rose

Denver, Colorado, 80220, United States
Rocky Mountain Cancer Centers-Sky Ridge

Lone Tree, Colorado, 80124, United States
Rocky Mountain Cancer Centers-Thornton

Thornton, Colorado, 80260, United States
Rose Medical Center

Denver, Colorado, 80220, United States
Rush MD Anderson Cancer Center

Chicago, Illinois, 60612, United States
SIH Cancer Institute

Carterville, Illinois, 62918, United States
SMC Center for Hematology Oncology Union

Union, South Carolina, 29379, United States
SSM Health Good Samaritan

Mount Vernon, Illinois, 62864, United States
Saint Alphonsus Cancer Care Center-Baker City

Baker City, Oregon, 97814, United States
Saint Alphonsus Cancer Care Center-Boise

Boise, Idaho, 83706, United States
Saint Alphonsus Cancer Care Center-Caldwell

Caldwell, Idaho, 83605, United States
Saint Alphonsus Cancer Care Center-Nampa

Nampa, Idaho, 83687, United States
Saint Alphonsus Cancer Care Center-Ontario

Ontario, Oregon, 97914, United States
Saint Charles Health System

Bend, Oregon, 97701, United States
Saint Charles Health System-Redmond

Redmond, Oregon, 97756, United States
Saint Elizabeth Boardman Hospital

Boardman, Ohio, 44512, United States
Saint Elizabeth Youngstown Hospital

Youngstown, Ohio, 44501, United States
Saint Francis Medical Center

Cape Girardeau, Missouri, 63703, United States
Saint Francis Regional Medical Center

Shakopee, Minnesota, 55379, United States
Saint George Regional Medical Center

St. George, Utah, 84770, United States
Saint James Community Hospital and Cancer Treatment Center

Butte, Montana, 59701, United States
Saint John's Hospital - Healtheast

Maplewood, Minnesota, 55109, United States
Saint Joseph Hospital - Cancer Centers of Colorado

Denver, Colorado, 80218, United States
Saint Joseph Warren Hospital

Warren, Ohio, 44484, United States
Saint Luke's Cancer Institute - Boise

Boise, Idaho, 83712, United States
Saint Luke's Cancer Institute - Fruitland

Fruitland, Idaho, 83619, United States
Saint Luke's Cancer Institute - Meridian

Meridian, Idaho, 83642, United States
Saint Luke's Cancer Institute - Nampa

Nampa, Idaho, 83687, United States
Saint Luke's Cancer Institute - Twin Falls

Twin Falls, Idaho, 83301, United States
Saint Luke's Hospital

Chesterfield, Missouri, 63017, United States
Saint Mary's Hospital and Regional Medical Center

Grand Junction, Colorado, 81501, United States
Saint Mary's Oncology/Hematology Associates of Marlette

Marlette, Michigan, 48453, United States
Saint Mary's Oncology/Hematology Associates of West Branch

West Branch, Michigan, 48661, United States
Saint Patrick Hospital - Community Hospital

Missoula, Montana, 59802, United States
Saint Vincent Frontier Cancer Center

Billings, Montana, 59102, United States
Saint Vincent Healthcare

Billings, Montana, 59101, United States
Sainte Genevieve County Memorial Hospital

Sainte Genevieve, Missouri, 63670, United States
San Juan City Hospital

San Juan, 00936, Puerto Rico
San Juan Community Oncology Group

San Juan, 00917, Puerto Rico
Sandra L Maxwell Cancer Center

Cedar City, Utah, 84720, United States
Sky Ridge Medical Center

Lone Tree, Colorado, 80124, United States
Southern Illinois University School of Medicine

Springfield, Illinois, 62702, United States
Southwest Illinois Health Services LLP

Swansea, Illinois, 62226, United States
Spartanburg Medical Center

Spartanburg, South Carolina, 29303, United States
Spartanburg Medical Center - Mary Black Campus

Spartanburg, South Carolina, 29307, United States
Springfield Clinic

Springfield, Illinois, 62702, United States
Springfield Memorial Hospital

Springfield, Illinois, 62781, United States
Springfield Regional Cancer Center

Springfield, Ohio, 45504, United States
Springfield Regional Medical Center

Springfield, Ohio, 45504, United States
Stony Brook University Medical Center

Stony Brook, New York, 11794, United States
Straub Clinic and Hospital

Honolulu, Hawaii, 96813, United States
Straub Medical Center - Kahului Clinic

Kahului, Hawaii, 96732, United States
Swedish Cancer Institute-Edmonds

Edmonds, Washington, 98026, United States
Swedish Cancer Institute-Issaquah

Issaquah, Washington, 98029, United States
Swedish Medical Center

Englewood, Colorado, 80113, United States
Swedish Medical Center-Ballard Campus

Seattle, Washington, 98107, United States
Swedish Medical Center-Cherry Hill

Seattle, Washington, 98122-5711, United States
Swedish Medical Center-First Hill

Seattle, Washington, 98122, United States
The Cancer Center of Hawaii-Liliha

Honolulu, Hawaii, 96817, United States
The Cancer Center of Hawaii-Pali Momi

‘Aiea, Hawaii, 96701, United States
The Medical Center of Aurora

Aurora, Colorado, 80012, United States
The Melanoma and Skin Cancer Institute

Englewood, Colorado, 80113, United States
The New York Hospital Medical Center of Queens

Flushing, New York, 11355, United States
The Queen's Medical Center - West Oahu

‘Ewa Beach, Hawaii, 96706, United States
The Valley Hospital - Luckow Pavilion

Paramus, New Jersey, 07652, United States
The Women's Imaging Center

Denver, Colorado, 80209, United States
Toledo Clinic Cancer Centers-Monroe

Monroe, Michigan, 48162, United States
Toledo Clinic Cancer Centers-Toledo

Toledo, Ohio, 43623, United States
Touro Infirmary

New Orleans, Louisiana, 70115, United States
Trinity Health Grand Rapids Hospital

Grand Rapids, Michigan, 49503, United States
Trinity Health IHA Medical Group Hematology Oncology - Brighton

Brighton, Michigan, 48114, United States
Trinity Health IHA Medical Group Hematology Oncology - Canton

Canton, Michigan, 48188, United States
Trinity Health IHA Medical Group Hematology Oncology - Chelsea Hospital

Chelsea, Michigan, 48118, United States
Trinity Health IHA Medical Group Hematology Oncology Ann Arbor Campus

Ypsilanti, Michigan, 48197, United States
Trinity Health Medical Center - Brighton

Brighton, Michigan, 48114, United States
Trinity Health Medical Center - Canton

Canton, Michigan, 48188, United States
Trinity Health Muskegon Hospital

Muskegon, Michigan, 49444, United States
Trinity Health Saint Joseph Mercy Hospital Ann Arbor

Ann Arbor, Michigan, 48106, United States
Trinity Health Saint Joseph Mercy Oakland Hospital

Pontiac, Michigan, 48341, United States
Trinity Health Saint Mary Mercy Livonia Hospital

Livonia, Michigan, 48154, United States
UF Health Cancer Institute - Gainesville

Gainesville, Florida, 32610, United States
UM Baltimore Washington Medical Center/Tate Cancer Center

Glen Burnie, Maryland, 21061, United States
UNC Lineberger Comprehensive Cancer Center

Chapel Hill, North Carolina, 27599, United States
UTMB Cancer Center at Victory Lakes

League City, Texas, 77573, United States
UW Cancer Center at ProHealth Care

Waukesha, Wisconsin, 53188, United States
United Hospital

Saint Paul, Minnesota, 55102, United States
Unity Hospital

Fridley, Minnesota, 55432, United States
University Medical Center New Orleans

New Orleans, Louisiana, 70112, United States
University of Alabama at Birmingham Cancer Center

Birmingham, Alabama, 35233, United States
University of California Davis Comprehensive Cancer Center

Sacramento, California, 95817, United States
University of Hawaii Cancer Center

Honolulu, Hawaii, 96813, United States
University of Kansas Cancer Center

Kansas City, Kansas, 66160, United States
University of Kansas Hospital-Indian Creek Campus

Overland Park, Kansas, 66211, United States
University of Kansas Hospital-Westwood Cancer Center

Westwood, Kansas, 66205, United States
University of Kentucky/Markey Cancer Center

Lexington, Kentucky, 40536, United States
University of Michigan Health - Sparrow Lansing

Lansing, Michigan, 48912, United States
University of Michigan Health - West

Wyoming, Michigan, 49519, United States
University of North Carolina-Hillsborough Campus

Hillsborough, North Carolina, 27278, United States
University of Oklahoma Health Sciences Center

Oklahoma City, Oklahoma, 73104, United States
University of Texas Health Science Center at San Antonio

San Antonio, Texas, 78229, United States
University of Texas Medical Branch

Galveston, Texas, 77555-0565, United States
Upper Valley Medical Center

Troy, Ohio, 45373, United States
Utah Cancer Specialists-Salt Lake City

Salt Lake City, Utah, 84106, United States
Utah Valley Regional Medical Center

Provo, Utah, 84604, United States
Valley Health System Ridgewood Campus

Ridgewood, New Jersey, 07450, United States
Valley Health System-Hematology/Oncology

Westwood, New Jersey, 07675, United States
Valley Radiation Oncology

Peru, Illinois, 61354, United States
Walter Knox Memorial Hospital

Emmett, Idaho, 83617, United States
Wayne Hospital

Greenville, Ohio, 45331, United States
Welch Cancer Center

Sheridan, Wyoming, 82801, United States
West Michigan Cancer Center

Kalamazoo, Michigan, 49007, United States
Western Illinois Cancer Treatment Center

Galesburg, Illinois, 61401, United States
Western Surgical Care

Denver, Colorado, 80220, United States
Wilcox Memorial Hospital and Kauai Medical Clinic

Lihue, Hawaii, 96766, United States

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