Can a herbal supplement clean your Mouth's hidden biofilms?
NCT ID NCT07408245
First seen Jun 25, 2026 · Last updated Jul 30, 2026 · Updated 3 times
Summary
This pilot study is testing whether a botanical liquid called Biocidin can reduce oral biofilms—sticky layers of bacteria—in healthy adults. Sixty participants will take the supplement for two weeks and have their oral microbiome tested before and after. It's an early, small study to see if there's any effect worth exploring further.
What this could mean
Our plain-language read of the trial. This is informational only, not medical advice or a prediction.
- Active substance
- Biocidin liquid (a botanical supplement)
- What this could lead to
- If it works, this could point toward a natural supplement to help control oral biofilms and improve oral health.
- What could go wrong
- This is a very small, early pilot study with no control group. Results may not be generalizable, and any benefits might be minor or not statistically significant.
This is an AI summary of the original study and may miss details. Read our disclaimer.
Study facts
What this study's own registry entry says, in plain language.
- Phase
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Not a phased trial
Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.
- Participants
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50 people
The number who actually took part.
- Started
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Feb 2026
- Finished
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May 2026
- Lead sponsor
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A research network
The lead sponsor is a research network or cooperative group.
Who can take part
This study's own entry requirements. Only the study team can say for certain whether you qualify.
- Ages
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25 years and older
- Sex
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Anyone
- Healthy volunteers
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Accepted
You do not need to have the condition being studied to take part.
Show the full entry requirements Hide the full entry requirements
Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.
Inclusion Criteria: 1. Adult females or males age ≥ 25 years 2. Ability to read and speak English 3. Willingness to take use oral Biocidin as directed for two weeks 4. Willingness not to change any other oral health practices for two weeks 5. Willingness not to change dietary habits for two weeks 6. Willingness to perform a SimplyPERIO oral microbiome test before and after the two-week Biocidin intervention Exclusion Criteria: 1. Current use of oral Biocidin or botanical mouthwash 2. Use of antibiotics within the past 30 days 3. Current use of fixed intraoral orthodontic appliances (e.g., dental braces, fixed retainers, or similar devices) 4. Known allergies to any of the ingredients in the product 5. Currently pregnant or lactating women or women planning to become pregnant in the next 12 weeks 6. Participants unable to provide consent
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As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
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OvationLab
Richmond, Virginia, 23220, United States
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