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Can bioactive fillings help teeth heal themselves?

NCT ID NCT07171775

Disease control Sponsor: Cairo University Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting This study
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study tests whether a new bioactive filling material helps teeth repair themselves after deep cavities are removed. 66 adults with deep decay will get either the bioactive filling or a standard one. Researchers will check for new tooth layer formation and pain over 2 years.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
bioactive restorative system (adhesive and resin composite)
What this could lead to
If it works, this could show that bioactive materials help teeth repair themselves after deep cavities, reducing the need for more invasive treatments.
What could go wrong
This is an early-stage trial with only 66 people, so results may not apply to everyone. The bioactive materials might not perform better than standard fillings, and long-term benefits are uncertain.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

About 66 people

The number the study aims to enrol. It can still change while the study runs.

Expected to start

Jun 2026

An estimate. Start dates often move.

Expected to finish

Jun 2028

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 to 40 years

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: Patient-related criteria: 1. Adult patients (age: 18-40 years) of both genders. 2. Good oral hygiene. 3. Willing to sign the informed consent. 4. Cooperative patients who accept the follow-up period. Tooth-related criteria: 1. Posterior permanent caries (ICDAS 5-6). 2. Radiographically, caries is extending 50% of dentine with a radiopaque layer between the carious lesion and the pulp chamber. 3. Sensitive teeth according to the cold pulp test. 4. Negative response in percussion test. Exclusion Criteria: Patient-related criteria: 1. Allergy to any of the restorative materials. 2. Patients undergoing orthodontic treatment with fixed appliances. 3. Pregnant women. 4. Patients with debilitating systemic diseases. 5. Patient who frequently uses analgesics or any drugs that could mask the pain. Tooth-related criteria: 1. Teeth with previous restorations. 2. Spontaneous pain or prolonged pain (more than 15 s) after the sensitivity test (cold test), which would indicate irreversible pulpitis. 3. Negative sensibility tests, periapical radiolucency, and sensitivity to axial or lateral percussion. 4. Mobile teeth, indicating periodontal disease or trauma. 5. External or internal resorption. 6. Chipped teeth or Cuspal loss

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Conditions

The condition(s) this trial relates to.

dental caries dentin caries

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Deep carious lesions Dentin bridge Partial caries removal

How to take part

Only the study team decides who joins. These are the ways to reach them.

  1. The official record

    ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.

    Open the record ↗

  2. A doctor treating you

    A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.

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