Brain scans reveal how stress fuels binge eating
NCT ID NCT04125589
First seen Jun 27, 2026 · Last updated Jun 27, 2026
Summary
This study looked at how stress and negative emotions influence decision-making and eating behavior in women with binge-eating disorder. Researchers used brain scans to understand activity in reward and self-control areas during everyday choices. The goal was to learn more about the brain processes behind binge eating, not to test a treatment.
This is an AI summary of the original study and may miss details. Read our disclaimer.
Study facts
What this study's own registry entry says, in plain language.
- Phase
-
Not a phased trial
Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.
- Participants
-
77 people
The number who actually took part.
- Started
-
Dec 2019
- Finished
-
Jun 2025
- Lead sponsor
-
Other sponsor
The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.
Who can take part
This study's own entry requirements. Only the study team can say for certain whether you qualify.
- Ages
-
18 to 40 years
- Sex
-
Female participants only
- Healthy volunteers
-
Accepted
You do not need to have the condition being studied to take part.
Show the full entry requirements Hide the full entry requirements
Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.
INCLUSION CRITERIA: Inclusion Criteria for All Participants: * Normal or corrected to normal vision and hearing * Verbal and written fluency in English * Right-handed * Body mass index of 20-35 kg/m\^2 Additional Inclusion Criteria for Participants with Binge-Eating Disorder: • DSM-5 binge-eating disorder EXCLUSION CRITERIA: Exclusion Criteria for All Participants: * Impaired cognition or other neurological/cognitive problems * Contraindications to MRI (e.g., certain metal implants, claustrophobia) * Currently/recently/potentially pregnant, seeking to become pregnant in the near future, or breastfeeding * Serious and/or unstable medical diseases and conditions, and certain other medical diseases and conditions * Recent low weight * Certain medications (e.g., insulin) * Current/recent frequent recreational drug use, or history of frequent recreational drug use in early adolescence * Extreme dietary limitations (e.g., veganism), pervasive food allergies, or limited exposure to popular snack foods * Current/recent suicidality * Current/recent changes in treatment for mental illness * Study-relevant research experience Additional Exclusion Criteria for Comparison Participants: * Personal history of eating disorders or recurrent binge eating * Personal history of any other mental illness, including serious substance use problems * First-degree relative with current or past eating or psychotic disorder * Significant recent change in weight Additional Exclusion Criteria for Participants with Binge-Eating Disorder: * Severe mental illness (e.g., psychotic disorder, severe agoraphobia) * Certain other current/recent mental illness, including severe substance use problems, that would limit study participation or safety * Recent anorexia nervosa spectrum disorder, avoidant-restrictive food intake disorder, or bulimia nervosa spectrum disorder
Get updates
Get notified about this study
Sign up to get updates when this study changes or when new studies for Binge-eating disorder are added.
Genom att skicka in godkänner du våra Användarvillkor
Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
-
McLean Hospital
Belmont, Massachusetts, 02478, United States
More trials for these conditions
Other studies related to the condition(s) this trial covers.
- A new approach to curb binge eating may lower diabetes risk in young black women
- Could your phone help rewire binge-eating habits?
- Digital coaching may curb binge eating in black women with obesity
- Do diaries differ? study tests paper vs. digital for binge eating tracking
- Which talk therapy works best for binge eating? a Head-to-Head trial aims to find out
- 20,000-Person DNA hunt aims to crack eating disorder code