New hope for rare uterine cancer? trial tests avastin with chemo
NCT ID NCT01012297
First seen Jun 27, 2026 · Last updated Jun 27, 2026
Summary
This phase 3 trial tested whether adding bevacizumab (Avastin) to standard chemotherapy (docetaxel and gemcitabine) helps people with advanced or recurrent uterine leiomyosarcoma. The study enrolled 107 participants but was terminated early. Researchers measured how long patients lived without the cancer growing (progression-free survival) and overall survival. The goal was to see if the drug combo works better than chemo alone.
What this could mean
Our plain-language read of the trial. This is informational only, not medical advice or a prediction.
- Active substance
- Bevacizumab (Avastin) added to chemotherapy (docetaxel and gemcitabine)
- What this could lead to
- If it works, adding bevacizumab could help slow tumor growth or improve survival for people with advanced uterine leiomyosarcoma.
- What could go wrong
- The trial was terminated early with only 107 participants, so results are limited. Bevacizumab may not improve outcomes and can cause side effects like bleeding or high blood pressure.
This is an AI summary of the original study and may miss details. Read our disclaimer.
Study facts
What this study's own registry entry says, in plain language.
- Phase
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Phase 3
Large-scale testing in a bigger group. Usually the last step before a treatment can be approved.
- Participants
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107 people
The number who actually took part.
- Start date
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Nov 2009
- Finished
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Sep 2015
- Lead sponsor
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A government research agency
The lead sponsor is the US National Institutes of Health.
Who can take part
This study's own entry requirements. Only the study team can say for certain whether you qualify.
- Ages
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18 years and older
- Sex
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Female participants only
- Healthy volunteers
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Not accepted
This study is not open to healthy volunteers. The entry requirements below say who it is open to.
Show the full entry requirements Hide the full entry requirements
Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.
Inclusion Criteria: * Patients must have advanced or recurrent uterine leiomyosarcoma with documented disease progression; histologic confirmation of the original primary tumor is required * All patients must have measurable disease as defined by RECIST 1.1; measurable disease is defined as at least one lesion that can be accurately measured in at least one dimension (longest diameter to be recorded); each lesion must be \>= 10 mm when measured by CT, MRI or caliper measurement by clinical exam; or \>= 20 mm when measured by chest x-ray; lymph nodes must be \>= 15 mm in short axis when measured by CT or MRI * Patient must have at least one "target lesion" to be used to assess response on this protocol as defined by RECIST 1.1; tumors within a previously irradiated field will be designated as "non-target" lesions unless progression is documented or a biopsy is obtained to confirm persistence at least 90 days following completion of radiation therapy * Patients must have a GOG Performance Status of 0, 1, or 2 * Patients must have recovered from effects of recent surgery, radiotherapy or other therapy * Patients should be free of active infection requiring antibiotics (with the exception of an uncomplicated UTI) * Any hormonal therapy directed at the malignant tumor must be discontinued at least one week prior to first day of study treatment; continuation of hormone replacement therapy is permitted * Platelet count greater than or equal to 100,000/mm\^3 * ANC count greater than or equal to 1,500/mm\^3 * Creatinine less than or equal to 1.5 x institutional upper limit normal (ULN), per NCI CTCAE Version 4.0 Grade 1 * Bilirubin within normal range (CTCAE Version 4 Grade 0) * SGOT and alkaline phosphatase less than or equal to 2.5 x ULN, per the CTCAE Version 4.0 Grade 1) * SGOT less than or equal to 2.5 x ULN, per the CTCAE Version 4.0 Grade 1 * Alkaline phosphatase less than or equal to 2.5 x ULN, per the CTCAE Version 4.0 Grade 1 * Neuropathy (sensory and motor) less than or equal to Grade 1 per the CTCAE Version 4.0. * No history of transient ischemic attack (TIA) or stroke or CNS hemorrhage within the past 6 months * Urine protein creatinine (UPC) ratio must be \< 1.0 gm; if UPC ratio \>= 1, collection of 24-hour urine measurement of urine protein is recommended * PT such that international normalized ratio (INR) is =\< 1.5 and a PTT =\< 1.5 times the institutional upper limit of normal (or an in-therapeutic-range INR, usually between 2 and 3, if a patient is on a stable dose of therapeutic warfarin) * Patients must have signed an approved informed consent and authorization permitting release of personal health information * Patients must meet pre-entry requirements * Patients of childbearing potential must have a negative serum pregnancy test prior to the study entry and be practicing an effective form of contraception Exclusion Criteria: * Patients who have received prior cytotoxic chemotherapy for management of uterine sarcoma; patients who have received prior VEGF-pathway targeted agent such as bevacizumab, PTK787, VEGF-trap, or who have received prior treatment with a multi-kinase inhibitor such as sorafenib or sunitinib are not eligible * Patients who have had prior therapy with docetaxel or gemcitabine or bevacizumab * Patients with a history of other invasive malignancies, with the exceptions of non-melanoma skin cancer, carcinoma in situ of the cervix, and ductal carcinoma in situ of the breast, are excluded if there is any evidence of other malignancy being present within the last five years; patients are also excluded if their previous cancer treatment contraindicates this protocol therapy * Patients with active bleeding or pathologic conditions that carry high risk of bleeding, such as known bleeding disorder, coagulopathy, or tumor involving major vessels; (necessary use of warfarin or low molecular weight heparin is permitted, provided the INR is maintained in the therapeutic range of approximately 2-3) * Patients with major surgery or significant traumatic injury within 28 days prior to study entry * Patients with a history of abdominal fistula or perforation within the past 12 months * Patients with a current, serious, non-healing wound, ulcer, or bone fracture * Patients with history or evidence upon physical examination of CNS disease, including history of primary brain tumor, or any history of brain metastases, or seizures not controlled with standard medical therapy * Patients with known hypersensitivity to Chinese hamster ovary cell products or other recombinant human or humanized antibodies * Cardiovascular function; specifically, patient may not have: * Uncontrolled hypertension, defined as systolic \> 150 mm Hg or diastolic \> 100 mm Hg in a patient with no history of hypertension; patients with a history of hypertension before enrollment on study are permitted, but such patients must have BP less than or equal to 140/90 mmHg; use of blood pressure medications to achieve and maintain blood pressure control is permitted * Myocardial infarction or unstable angina within 6 months of the first date of bevacizumab/placebo therapy * New York Heart Association (NYHA) Grade II or greater congestive heart failure or serious cardiac arrhythmia requiring medication; women who have received prior treatment with an anthracycline (including doxorubicin and/or liposomal doxorubicin) and have an ejection fraction \< 50% will be excluded from the study * Grade 1, Category 2 or greater, peripheral vascular disease; patient cannot have anything worse than mild, symptomatic claudication with exercise * History of cerebrovascular accident (CVA, stroke), transient ischemic attack (TIA) or subarachnoid hemorrhage within six months of the first date of bevacizumab/placebo therapy * History of pulmonary embolism or deep vein thrombosis in the past 6 months * Patients with, or with anticipation of, invasive procedures as defined below: * Major surgical procedure, open biopsy or significant traumatic injury within 28 days prior to the first date of bevacizumab/placebo therapy * Major surgical procedure anticipated during the course of the study. * Minor surgical procedures (i.e., mediport insertion), fine needle aspirates, or core biopsies within 7 days prior to the first date of bevacizumab/placebo therapy * Patients who are pregnant or nursing
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Get notified about this study
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
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Abbott-Northwestern Hospital
Minneapolis, Minnesota, 55407, United States
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Abington Memorial Hospital
Abington, Pennsylvania, 19001, United States
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Avera Cancer Institute
Sioux Falls, South Dakota, 57105, United States
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Baptist Health Lexington
Lexington, Kentucky, 40503, United States
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Baylor All Saints Medical Center at Fort Worth
Fort Worth, Texas, 76104, United States
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Beebe Medical Center
Lewes, Delaware, 19958, United States
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Borgess Medical Center
Kalamazoo, Michigan, 49001, United States
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Boulder Community Hospital
Boulder, Colorado, 80301, United States
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Bronson Battle Creek
Battle Creek, Michigan, 49017, United States
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Bronson Methodist Hospital
Kalamazoo, Michigan, 49007, United States
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Cadence Cancer Center in Warrenville
Warrenville, Illinois, 60555, United States
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Cancer Center of Western Wisconsin
New Richmond, Wisconsin, 54017, United States
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Cancer Research for the Ozarks NCORP
Springfield, Missouri, 65804, United States
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Carolinas HealthCare System NorthEast
Concord, North Carolina, 28025, United States
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Carolinas Medical Center/Levine Cancer Institute
Charlotte, North Carolina, 28203, United States
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Case Western Reserve University
Cleveland, Ohio, 44106, United States
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Center of Hope at Renown Medical Center
Reno, Nevada, 89502, United States
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Christiana Care Health System-Christiana Hospital
Newark, Delaware, 19718, United States
-
Clements University Hospital
Dallas, Texas, 75390, United States
-
Cleveland Clinic Cancer Center/Fairview Hospital
Cleveland, Ohio, 44111, United States
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Cleveland Clinic Foundation
Cleveland, Ohio, 44195, United States
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Colorado Cancer Research Program CCOP
Denver, Colorado, 80224-2522, United States
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Community Howard Regional Health
Kokomo, Indiana, 46904, United States
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Cooper Hospital University Medical Center
Camden, New Jersey, 08103, United States
-
CoxHealth South Hospital
Springfield, Missouri, 65807, United States
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Dartmouth Hitchcock Medical Center
Lebanon, New Hampshire, 03756, United States
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Duke University Medical Center
Durham, North Carolina, 27710, United States
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Elkhart Clinic
Elkhart, Indiana, 46514-2098, United States
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Elkhart General Hospital
Elkhart, Indiana, 46515, United States
-
Exempla Saint Joseph Hospital
Denver, Colorado, 80218, United States
-
Fairview Ridges Hospital
Burnsville, Minnesota, 55337, United States
-
Fairview-Southdale Hospital
Edina, Minnesota, 55435, United States
-
Florida Hospital Orlando
Orlando, Florida, 32803, United States
-
Fox Chase Cancer Center
Philadelphia, Pennsylvania, 19111, United States
-
Franciscan Saint Francis Health-Indianapolis
Indianapolis, Indiana, 46237, United States
-
Geisinger Medical Center
Danville, Pennsylvania, 17822, United States
-
Geisinger Medical Center-Cancer Center Hazleton
Hazleton, Pennsylvania, 18201, United States
-
Geisinger Medical Group
State College, Pennsylvania, 16801, United States
-
Geisinger Wyoming Valley/Henry Cancer Center
Wilkes-Barre, Pennsylvania, 18711, United States
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Georgia Regents University Medical Center
Augusta, Georgia, 30912, United States
-
Grand Rapids Clinical Oncology Program
Grand Rapids, Michigan, 49503, United States
-
Greater Baltimore Medical Center
Baltimore, Maryland, 21204, United States
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Gynecologic Oncology of Indiana
Indianapolis, Indiana, 46237, United States
-
Hartford Hospital
Hartford, Connecticut, 06102, United States
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Hennepin County Medical Center
Minneapolis, Minnesota, 55415, United States
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Hillcrest Hospital Cancer Center
Mayfield Heights, Ohio, 44124, United States
-
Huntsman Cancer Institute/University of Utah
Salt Lake City, Utah, 84112, United States
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Hutchinson Area Health Care
Hutchinson, Minnesota, 55350, United States
-
IU Health La Porte Hospital
La Porte, Indiana, 46350, United States
-
Indiana University/Melvin and Bren Simon Cancer Center
Indianapolis, Indiana, 46202, United States
-
Iowa Lutheran Hospital
Des Moines, Iowa, 50316, United States
-
Iowa Methodist Medical Center
Des Moines, Iowa, 50309, United States
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Iowa Oncology Research Association CCOP
Des Moines, Iowa, 50309, United States
-
John B Amos Cancer Center
Columbus, Georgia, 31904, United States
-
John Muir Medical Center-Concord Campus
Concord, California, 94520, United States
-
John Muir Medical Center-Walnut Creek
Walnut Creek, California, 94598, United States
-
Johns Hopkins University/Sidney Kimmel Cancer Center
Baltimore, Maryland, 21287, United States
-
Kaiser Permanente Los Angeles Medical Center
Los Angeles, California, 90027, United States
-
Kettering Medical Center
Kettering, Ohio, 45429, United States
-
Lahey Hospital and Medical Center
Burlington, Massachusetts, 01805, United States
-
Lake University Ireland Cancer Center
Mentor, Ohio, 44060, United States
-
Lakeland Hospital
Saint Joseph, Michigan, 49085, United States
-
Lakeview Hospital
Stillwater, Minnesota, 55082, United States
-
Lehigh Valley Hospital-Cedar Crest
Allentown, Pennsylvania, 18103, United States
-
Littleton Adventist Hospital
Littleton, Colorado, 80122, United States
-
Longmont United Hospital
Longmont, Colorado, 80501, United States
-
Los Angeles County-USC Medical Center
Los Angeles, California, 90033, United States
-
M D Anderson Cancer Center
Houston, Texas, 77030, United States
-
Marie Yeager Cancer Center
Saint Joseph, Michigan, 49085, United States
-
Mayo Clinic
Rochester, Minnesota, 55905, United States
-
Mayo Clinic in Florida
Jacksonville, Florida, 32224-9980, United States
-
McKee Medical Center
Loveland, Colorado, 80539, United States
-
MedStar Franklin Square Medical Center/Weinberg Cancer Institute
Baltimore, Maryland, 21237, United States
-
Medical Oncology and Hematology Associates-Des Moines
Des Moines, Iowa, 50309, United States
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Medical Oncology and Hematology Associates-Laurel
Des Moines, Iowa, 50314, United States
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Medical Oncology and Hematology Associates-West Des Moines
Clive, Iowa, 50325, United States
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Medical University of South Carolina
Charleston, South Carolina, 29425, United States
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Memorial Hospital of South Bend
South Bend, Indiana, 46601, United States
-
Memorial Medical Center
Springfield, Illinois, 62781, United States
-
Memorial Medical Center - Las Cruces
Las Cruces, New Mexico, 88011, United States
-
Memorial Sloan-Kettering Cancer Center
New York, New York, 10065, United States
-
Memorial University Medical Center
Savannah, Georgia, 31404, United States
-
Mercy Cancer Center-West Lakes
Clive, Iowa, 50325, United States
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Mercy Health Mercy Campus
Muskegon, Michigan, 49444, United States
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Mercy Health Saint Mary's
Grand Rapids, Michigan, 49503, United States
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Mercy Hospital
Miami, Florida, 33133, United States
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Mercy Hospital
Coon Rapids, Minnesota, 55433, United States
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Mercy Hospital Springfield
Springfield, Missouri, 65804, United States
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Mercy Medical Center - Des Moines
Des Moines, Iowa, 50314, United States
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Mercy Medical Center-West Lakes
West Des Moines, Iowa, 50266, United States
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Methodist West Hospital
West Des Moines, Iowa, 50266-7700, United States
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Metro Health Hospital
Wyoming, Michigan, 49519, United States
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Metro-Minnesota NCI Community Oncology Research Program
Saint Louis Park, Minnesota, 55416, United States
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MetroHealth Medical Center
Cleveland, Ohio, 44109, United States
-
Michiana Hematology Oncology PC-Elkhart
Elkhart, Indiana, 46514, United States
-
Michiana Hematology Oncology PC-Mishawaka
Mishawaka, Indiana, 46545, United States
-
Michiana Hematology Oncology PC-Niles
Niles, Michigan, 49120, United States
-
Michiana Hematology Oncology PC-Plymouth
Plymouth, Indiana, 46563, United States
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Michiana Hematology Oncology PC-South Bend
South Bend, Indiana, 46601, United States
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Michiana Hematology Oncology PC-Westville
Westville, Indiana, 46391, United States
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Minnesota Oncology Hematology PA-Maplewood
Maplewood, Minnesota, 55109, United States
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Minnesota Oncology and Hematology PA-Woodbury
Woodbury, Minnesota, 55125, United States
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Morristown Medical Center
Morristown, New Jersey, 07960, United States
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Mount Sinai Medical Center
New York, New York, 10029, United States
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Munson Medical Center
Traverse City, Michigan, 49684, United States
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Nebraska Methodist Hospital
Omaha, Nebraska, 68114, United States
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New Ulm Medical Center
New Ulm, Minnesota, 56073, United States
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North Colorado Medical Center
Greeley, Colorado, 80631, United States
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North Memorial Medical Health Center
Robbinsdale, Minnesota, 55422, United States
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North Suburban Medical Center
Thornton, Colorado, 80229, United States
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Northern Indiana Cancer Research Consortium CCOP
South Bend, Indiana, 46628, United States
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Northwestern University
Chicago, Illinois, 60611, United States
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Norton Hospital Pavilion and Medical Campus
Louisville, Kentucky, 40202, United States
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Novant Health Presbyterian Medical Center
Charlotte, North Carolina, 28204, United States
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Ohio State University Comprehensive Cancer Center
Columbus, Ohio, 43210, United States
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Olive View-University of California Los Angeles Medical Center
Sylmar, California, 91342, United States
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Overlook Hospital
Summit, New Jersey, 07902, United States
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Palo Alto Medical Foundation-Gynecologic Oncology
Mountain View, California, 94040, United States
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Park Nicollet Clinic - Saint Louis Park
Saint Louis Park, Minnesota, 55416, United States
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Parker Adventist Hospital
Parker, Colorado, 80138, United States
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Parkland Memorial Hospital
Dallas, Texas, 75235, United States
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Penn State Milton S Hershey Medical Center
Hershey, Pennsylvania, 17033-0850, United States
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Pennsylvania Hospital
Philadelphia, Pennsylvania, 19107, United States
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Penrose-Saint Francis Healthcare
Colorado Springs, Colorado, 80907, United States
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Porter Adventist Hospital
Denver, Colorado, 80210, United States
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Presbyterian - Saint Lukes Medical Center - Health One
Denver, Colorado, 80218, United States
-
Providence Saint Joseph Medical Center/Disney Family Cancer Center
Burbank, California, 91505, United States
-
Reading Hospital
West Reading, Pennsylvania, 19611, United States
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Regions Hospital
Saint Paul, Minnesota, 55101, United States
-
Rice Memorial Hospital
Willmar, Minnesota, 56201, United States
-
Ridgeview Medical Center
Waconia, Minnesota, 55387, United States
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Riverside Methodist Hospital
Columbus, Ohio, 43214, United States
-
Rocky Mountain Gynecologic Oncology PC
Englewood, Colorado, 80110, United States
-
Rose Medical Center
Denver, Colorado, 80220, United States
-
Rush University Medical Center
Chicago, Illinois, 60612, United States
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Rutgers Cancer Institute of New Jersey
New Brunswick, New Jersey, 08903, United States
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SCL Health Lutheran Medical Center
Wheat Ridge, Colorado, 80033, United States
-
Saint Anthony Hospital
Lakewood, Colorado, 80228, United States
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Saint Francis Regional Medical Center
Shakopee, Minnesota, 55379, United States
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Saint John's Hospital - Healtheast
Maplewood, Minnesota, 55109, United States
-
Saint Joseph Regional Medical Center-Mishawaka
Mishawaka, Indiana, 46545, United States
-
Saint Joseph's Hospital and Medical Center
Phoenix, Arizona, 85013, United States
-
Saint Mary Corwin Medical Center
Pueblo, Colorado, 81004, United States
-
Saint Mary's Hospital and Regional Medical Center
Grand Junction, Colorado, 81502, United States
-
Saint Vincent Oncology Center
Indianapolis, Indiana, 46260, United States
-
Sanford Cancer Center-Oncology Clinic
Sioux Falls, South Dakota, 57104, United States
-
Sanford USD Medical Center - Sioux Falls
Sioux Falls, South Dakota, 57117-5134, United States
-
Sky Ridge Medical Center
Lone Tree, Colorado, 80124, United States
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South Bend Clinic
South Bend, Indiana, 46617, United States
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Southwest Gynecologic Oncology Associates Inc
Albuquerque, New Mexico, 87106, United States
-
Spectrum Health Big Rapids Hospital
Big Rapids, Michigan, 49307, United States
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Spectrum Health Reed City Hospital
Reed City, Michigan, 49677, United States
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Spectrum Health at Butterworth Campus
Grand Rapids, Michigan, 49503, United States
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State University of New York Downstate Medical Center
Brooklyn, New York, 11203, United States
-
Stony Brook University Medical Center
Stony Brook, New York, 11794, United States
-
Sudarshan K Sharma MD Limted-Gynecologic Oncology
Hinsdale, Illinois, 60521, United States
-
Summa Akron City Hospital/Cooper Cancer Center
Akron, Ohio, 44304, United States
-
Swedish Medical Center
Englewood, Colorado, 80113, United States
-
The Hospital of Central Connecticut
New Britain, Connecticut, 06050, United States
-
The James Graham Brown Cancer Center at University of Louisville
Louisville, Kentucky, 40202, United States
-
The Medical Center of Aurora
Aurora, Colorado, 80012, United States
-
Tulsa Cancer Institute
Tulsa, Oklahoma, 74146, United States
-
UC Irvine Health/Chao Family Comprehensive Cancer Center
Orange, California, 92868, United States
-
UC San Diego Moores Cancer Center
La Jolla, California, 92093, United States
-
UCLA / Jonsson Comprehensive Cancer Center
Los Angeles, California, 90095, United States
-
UCSF Medical Center-Mount Zion
San Francisco, California, 94115, United States
-
UF Cancer Center at Orlando Health
Orlando, Florida, 32806, United States
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UMDNJ - Robert Wood Johnson University Hospital
New Brunswick, New Jersey, 08903, United States
-
UPMC-Magee Womens Hospital
Pittsburgh, Pennsylvania, 15213, United States
-
USC / Norris Comprehensive Cancer Center
Los Angeles, California, 90033, United States
-
UT Southwestern/Simmons Cancer Center-Dallas
Dallas, Texas, 75390, United States
-
Union Hospital of Cecil County
Elkton, Maryland, 21921, United States
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United Hospital
Saint Paul, Minnesota, 55102, United States
-
Unity Hospital
Fridley, Minnesota, 55432, United States
-
University of California San Diego
San Diego, California, 92103, United States
-
University of Chicago Comprehensive Cancer Center
Chicago, Illinois, 60637, United States
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University of Cincinnati
Cincinnati, Ohio, 45267, United States
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University of Colorado Cancer Center - Anschutz Cancer Pavilion
Aurora, Colorado, 80045, United States
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University of Iowa/Holden Comprehensive Cancer Center
Iowa City, Iowa, 52242, United States
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University of Kansas Cancer Center
Kansas City, Kansas, 66160, United States
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University of Maryland/Greenebaum Cancer Center
Baltimore, Maryland, 21201, United States
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University of Miami Miller School of Medicine-Sylvester Cancer Center
Miami, Florida, 33136, United States
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University of Mississippi Medical Center
Jackson, Mississippi, 39216, United States
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University of New Mexico
Albuquerque, New Mexico, 87102, United States
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University of New Mexico Cancer Center
Albuquerque, New Mexico, 87106, United States
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University of Oklahoma Health Sciences Center
Oklahoma City, Oklahoma, 73104, United States
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University of Vermont Medical Center
Burlington, Vermont, 05401, United States
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University of Wisconsin Hospital and Clinics
Madison, Wisconsin, 53792, United States
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Virtua Memorial
Mount Holly, New Jersey, 08060, United States
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Virtua West Jersey Hospital Voorhees
Voorhees Township, New Jersey, 08043, United States
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Wake Forest University Health Sciences
Winston-Salem, North Carolina, 27157, United States
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Walter Reed National Military Medical Center
Bethesda, Maryland, 20889-5600, United States
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Washington Hospital Center
Washington D.C., District of Columbia, 20010, United States
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Washington University School of Medicine
St Louis, Missouri, 63110, United States
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Wayne State University/Karmanos Cancer Institute
Detroit, Michigan, 48201, United States
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West Michigan Cancer Center
Kalamazoo, Michigan, 49007, United States
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West Penn Hospital
Pittsburgh, Pennsylvania, 15224, United States
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Women and Infants Hospital
Providence, Rhode Island, 02905, United States
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Women's Cancer Care Associates LLC
Albany, New York, 12208, United States
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Women's Cancer Center of Nevada
Las Vegas, Nevada, 89169, United States
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Zale Lipshy University Hospital
Dallas, Texas, 75235, United States
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