Can antidepressants rewire how older adults see the future?

NCT ID NCT07681492

Knowledge-focused Sponsor: Hospital Center Guillaume Régnier Source: ClinicalTrials.gov ↗

First seen Jul 02, 2026 · Last updated Jul 02, 2026

Summary

This study investigates how depression and antidepressants influence the way older adults update their beliefs about future events. Researchers compare 31 patients aged 65+ with major depression who are switching antidepressants to 31 healthy volunteers of the same age. Participants complete a belief-updating task and mood assessments at the start and after 12 weeks of treatment, with weekly check-ins on expectations and mood.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

What this could lead to: If successful, this could reveal how antidepressants change the way older adults update their beliefs about the future, potentially improving treatment approaches.
What could go wrong: This is a small observational study (62 participants) focused on understanding mechanisms, not testing a new treatment. Results may not apply broadly.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

About 62 people

The number the study aims to enrol. It can still change while the study runs.

Started

Jan 2025

Expected to finish

Oct 2027

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

65 years and older

Sex

Anyone

Healthy volunteers

Accepted

You do not need to have the condition being studied to take part.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria for patients with major depressive disorder : * Patient over 65 years old in outpatient care * Patients with major depressive disorder or patients with bipolar major depressive disorder as evaluated by the Mini International Neuropsychiatric Interview (MINI) semi-structured interview for the group suffering from depression * Absence of cognitive impairment as evidenced by an MMSE (Mini Mental State Examination) ≥ 24 * MADRS ≥ 20 * MMSE ≥ 24 * Change of antidepressants * Person affiliated with a social security scheme * Patients who have received informed information about the study and have signed a consent form to participate in the study Exclusion Criteria with major depressive disorder : * mental disorders other than mood disorders : attention deficit dissorder, borderline personality disorder, schizophrenia, autism spectrum disorder, anorexia-bulimia disorder, obsessive-compulsive disorder, anxiety disorders and substance use disorder (except tobacco). * Inability to understand task instructions and perform the behavioral task * Neurological or neurosurgical comorbidities * Major visual impairment * Adults under state medical aid * Adults under legal protection (legal guardianship, curatorship, trusteeship), persons deprived of their liberty Inclusion Criteria for patients with major depressive disorder : * Absence of psychiatric disorders attested by administration of the MINI * Absence of cognitive impairment as evidenced by an MMSE ≥ 24

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Conditions

The condition(s) this trial relates to.

bipolar depression Depression depressive disorder major depressive disorder

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Beliefs Beliefs about future Depression Major depressive episode (MDE)

How to take part

Only the study team decides who joins. These are the ways to reach them.

The places running it

2 sites. The list below names each one and where it is.
The official record

ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.

Open the record ↗
A doctor treating you

A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.

Can antidepressants rewire how older adults see the future?

What the study statuses mean