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Beetroot juice may speed gut recovery after surgery

NCT ID NCT05133024

Disease control Sponsor: University Hospital, Ghent Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now This study
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study tests whether drinking beetroot juice for a week before colorectal surgery can help the gut start working again sooner. About 170 adults will be randomly assigned to drink either real beetroot juice or a placebo. Researchers will track when patients can eat solid food and pass gas or stool, and will also study blood and tissue samples to understand how beetroot juice affects inflammation.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Phase 2

Tests whether the treatment actually works, and watches for side effects, in a larger group.

Participants

About 170 people

The number the study aims to enrol. It can still change while the study runs.

Started

Mar 2021

Expected to finish

Dec 2027

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 years and older

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Adult patients undergoing elective colonic and upper rectum laparoscopic surgery requiring an anastomosis, without the need of conversion Exclusion Criteria: General: * \< 18 years of age * Pregnancy or breast feeding Medical: * Psychiatric pathology capable of affecting comprehension and judgment faculty * History of inflammatory bowel disease * Chronic vascular disease affecting the intestines * Chronic constipation (\<= 2 bowel movements/week) * Previous abdominal or pelvic radiation treatment * Recent (\< 3 months before inclusion) or current intra-abdominal infection or inflammation (e.g. diverticulitis, appendicitis, cholecystitis) * Use of gut motility influencing agents (e.g. tricyclic antidepressants, chronic use of laxatives) * Use of nitrates (e.g. isosorbide dinitrate, nitroglycerin), including daily consumption of beetroot juice (unless stopped for a month prior to the intervention period) * Hypotension (\< 100/60 mmHg) * Uncontrolled diabetes mellitus * Renal or hepatic insufficiency * Known allergies or intolerances to beetroot, nitrates/nitrites * Enrollment in other clinical trials/experiments, unless approved by the Ethics Committee(s) Surgical: * History of prior colorectal surgery * Emergency surgery * Open surgery * Colorectal surgery not requiring an anastomosis (e.g. colotomy, wedge resection) * More than 1 bowel anastomosis planned * Concomitant surgical procedures required (e.g. resection of liver or lung metastases) * Protective stoma planned

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Conditions

The condition(s) this trial relates to.

paralytic ileus

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Postoperative ileus

How to take part

Only the study team decides who joins. These are the ways to reach them.

  1. The places running it

    5 sites. The list below names each one and where it is.

  2. The official record

    ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.

    Open the record ↗

  3. A doctor treating you

    A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.

Contacts and locations

Locations

  • AZ Sint-Lucas Ghent

    RECRUITING

    Ghent, 9000, Belgium

  • Antwerp University Hospital

    RECRUITING

    Edegem, 2650, Belgium

  • Ghent University Hospital

    RECRUITING

    Ghent, 9000, Belgium

  • Hospital East-Limburg

    ACTIVE_NOT_RECRUITING

    Genk, 3600, Belgium

  • University Hospital Leuven

    RECRUITING

    Leuven, 3000, Belgium

  • VITAZ

    RECRUITING

    Sint-Niklaas, 9100, Belgium

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