New drug tested to tame rogue immune system attacking the liver

NCT ID NCT05569759

Completed Disease control Sponsor: Kezar Life Sciences, Inc. Source: ClinicalTrials.gov ↗

Summary

This study tested whether adding an investigational drug called zetomipzomib to standard steroid therapy could better control autoimmune hepatitis. It involved 24 adults whose liver disease was still active despite standard care. Participants received weekly injections of either the drug or a placebo for 24 weeks, with an option for continued treatment.

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Contacts and locations

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Locations

Beth Israel Deaconess Medical Center

Boston, Massachusetts, 02215, United States
California Pacific Medical Center

San Francisco, California, 94109, United States
Duke University Medical Center

Durham, North Carolina, 27710, United States
Indiana University

Indianapolis, Indiana, 46202, United States
Keck School of Medicine of USC

Los Angeles, California, 90033, United States
Massachusetts General Hospital

Boston, Massachusetts, 02114, United States
Mayo Clinic Arizona

Phoenix, Arizona, 85054, United States
Mayo Clinic Florida

Jacksonville, Florida, 32224, United States
New York University Langone Health/Grossman School of Medicine

New York, New York, 10016, United States
Northwell Health Center for Liver Disease and Transplantation

Manhasset, New York, 11030, United States
Northwestern University

Chicago, Illinois, 60611, United States
Ochsner Clinic Foundation

New Orleans, Louisiana, 70121, United States
Rush University

Chicago, Illinois, 60612, United States
Stanford Medicine

Redwood City, California, 94063, United States
University Hospitals Cleveland Medical Center

Cleveland, Ohio, 44106, United States
University of California, Los Angeles

Los Angeles, California, 90095, United States
University of California, San Francisco

San Francisco, California, 94132, United States
University of Colorado

Aurora, Colorado, 80045, United States
University of Miami

Miami, Florida, 33136, United States
University of Michigan Medical Center

Ann Arbor, Michigan, 48109, United States
University of Pennsylvania

Philadelphia, Pennsylvania, 19104, United States
Virginia Commonwealth University

Richmond, Virginia, 23298, United States
Washington University School of Medicine

St Louis, Missouri, 63110, United States
Yale University

New Haven, Connecticut, 06510, United States

Conditions

Explore the condition pages connected to this study.

AUTOIMMUNE HEPATITIS